The Current Toolbox for Covalent Inhibitors: From Hit Identification to Drug Discovery [0.03%]
共价抑制剂的药物发现流程及相关技术工具箱概述
Mengke You,Hong Liu,Chunpu Li
Mengke You
Covalent modification of therapeutic targets has emerged as a powerful platform for creating clinical drugs and chemical probes. Covalent drugs have evolved from serendipitous discoveries to rationally designed therapeutics, driven by advan...
Catalysis of Native Chemical Ligation and Expressed Protein Ligation by Alkylselenols [0.03%]
烷基硒醇催化本征型化学连接和表达蛋白质连接反应
Iván Sánchez-Campillo,Esther Gratacòs-Batlle,Selene Pérez-García et al.
Iván Sánchez-Campillo et al.
The reaction between C-terminal α-thioester and N-terminal cysteinyl peptides is known as native chemical ligation (NCL). Alkyl α-thioesters are traditionally prepared in NCL due to their higher thermodynamic stability, which endows resis...
Enzymology and Structural Basis of Glycosyltransferases Involved in Saponin C28 Carboxylic Acid O‑d‑Fucosylation [0.03%]
糖苷转移酶的酶学和结构基础参与皂甙C28羧酸O-D-岩藻糖基化
Graham A Hudson,Jose H Pereira,Peter H Winegar et al.
Graham A Hudson et al.
Saponins are a class of natural products composed of an oxidized triterpene core adorned with glycosylations, ultimately giving rise to medicinally important compounds bearing bioactivity that includes, but is not limited to, anti-inflammat...
Self-Reporting Aggregation-Induced Emission Gene Transfection System via Multivalent Tetrazole-Amine Complexation [0.03%]
基于多价四唑-胺配位的自报告型聚集诱导发光基因转染系统
Shuodong Wang,Xianhuang Li,Chunguang Yin et al.
Shuodong Wang et al.
Gene transfection visualization provides intuitive and direct evidence of gene function and cellular signaling pathways through dynamic, real-time tracking of gene delivery and expression. In this work, we synthesized two tetraphenylethylen...
Correction to "DNA Nanotags for Multiplexed Single-Particle Electron Microscopy and In Situ Electron Cryotomography" [0.03%]
关于《用于单粒子电子显微镜和就地冷冻断层扫描的DNA纳米标签》的更正
Yuanfang Chen,Yiqian Huang,Yuhe R Yang
Yuanfang Chen
[This corrects the article DOI: 10.1021/jacsau.4c00986.]. © 2025 The Authors. Published by American Chemical Society.
Published Erratum
JACS Au. 2025 Dec 6;5(12):6411. DOI:10.1021/jacsau.5c01523 2025
Climatic Conditions and Amine Loading Impact the Performance of Laminate-Supported Poly(ethylenimine) Direct Air Capture Sorbents [0.03%]
气候条件和胺负荷影响层压支撑聚乙二胺直接空气捕集吸附剂的性能
UnJin Ryu,Youn Ji Min,Wenyang Zhao et al.
UnJin Ryu et al.
Direct air capture (DAC) of CO2 is a critical technology to combat climate change, offering a scalable approach to mitigate atmospheric CO2 accumulation. Despite advancements in adsorbent materials, the performance of DAC systems remains hi...
Boron Radical Promoted Metal-Free Transformation of Nitroazobenzene into Benzotriazole [0.03%]
金属催化硝基重氮苯
Yanqi Chen,Yu Wang,Subin Hao et al.
Yanqi Chen et al.
Although the triazole skeleton is significant in biochemistry as a click reaction candidate, as well as in material chemistry due to its excellent absorption of UV light, the preparation of these compounds relies on multinitrogen reagents s...
Protein Confinement Decouples Dynamical Heterogeneity from Structural Preordering in Supercooled Monolayer Water [0.03%]
蛋白质限制使动力学异质性与过冷单层水的结构预排序脱耦
Tan Jin,Wei Zhuang
Tan Jin
Monolayer-confined supercooled water exhibits unique dynamic behavior with broad implications in science and engineering, from biomolecular interactions and energy storage to cryopreservation. However, under such extreme confinement, its dy...
Jibin Abraham Punnoose,Chai S Kam,Tristan Melfi et al.
Jibin Abraham Punnoose et al.
Nucleic acid structures are stabilized by both base pairing and base stacking. While energetics of base pairing interactions are relatively well established, our understanding of the energetic contributions of base stacking remain incomplet...
Late-Stage Native Peptide Modification Approach to the Total Synthesis of Koshidacins A and B [0.03%]
科氏色酮素A和B的晚期本征肽修饰法全合成
Hiroki Nakahara,Taichi Okano,Goh Sennari et al.
Hiroki Nakahara et al.
Herein, the total synthesis of the antimalarial natural products, koshidacins A and B, is disclosed. We developed an inverse peptide elongation sequence to elaborate the linear tetrapeptide by leveraging a soluble hydrophobic tag (TCbz grou...