Engineering a Functional Histidine Brace Copper-Binding Site into a De Novo-Designed Protein Scaffold [0.03%]
工程构建组氨酸支架铜结合位点到从头设计的蛋白质骨架中
Salvatore La Gatta,Linda Leone,Gianmattia Sgueglia et al.
Salvatore La Gatta et al.
De novo metalloprotein design has contributed to tremendous advances in bioinorganic chemistry by allowing the manufacturing of proteins with unique structures and functionalities that go beyond evolutionary constraints. Among the array of ...
Christopher W Jones
Christopher W Jones
Editorial
JACS Au. 2025 Oct 27;5(10):4636. DOI:10.1021/jacsau.5c01290 2025
Correction to "Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations" [0.03%]
“Tau蛋白突变通过促进伸展构象来促进聚集”的更正
Kevin Pounot,Clara Piersson,Andrew K Goring et al.
Kevin Pounot et al.
[This corrects the article DOI: 10.1021/jacsau.3c00550.]. © 2025 The Authors. Published by American Chemical Society.
Published Erratum
JACS Au. 2025 Oct 3;5(10):5234. DOI:10.1021/jacsau.5c01194 2025
Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides [0.03%]
环烷烃引入到锁核酸的2',4'-桥：增强抗核酸酶稳定性，减少磷硫修饰和降低反义寡核苷酸的肝毒性
Takao Yamaguchi,Hibiki Komine,Takaya Sugiura et al.
Takao Yamaguchi et al.
2'-O,4'-C-Methylene-bridged nucleic acid (2',4'-BNA), also known as locked nucleic acid (LNA), is widely used to modify antisense oligonucleotides (ASOs) because it significantly enhances their ability to form duplexes with target RNAs, the...
Unprecedented Copper/Iron-Cocatalyzed Homocoupling of Propargyl Ethers to Conjugated Benzofurans [0.03%]
前所未有的铜/铁双金属催化丙烯基醚的均偶联反应生成共轭苯并呋喃类化合物
Atreyee Halder,Tejender Singh,Aritri Saha et al.
Atreyee Halder et al.
A dual-catalytic strategy has been developed to access conjugated enyne benzofurans via an unprecedented unsymmetrical homocoupling of ortho-iodophenyl propargyl ethers. An earth-abundant Cu-(II)/Fe-(III) dual-catalyst system enables high c...
Unified Chemical Synthesis of Corynanthe-Sarpagine-Ajmaline Type Monoterpene Indole Alkaloids: A Biomimetic Approach [0.03%]
柯南他因-萨尔帕加明-阿杂米林类单萜吲哚生物碱的统一化学合成：一种模拟生物合成的方法
Ya-Kui Sun,Xiao-Feng Guo,Yu Bu et al.
Ya-Kui Sun et al.
The biosynthesis and chemical synthesis of corynanthe-sarpagine-ajmaline type monoterpene indole alkaloids, which share a close structural relationship, have presented key challenges in this field for decades. Herein, we present a biomimeti...
Mechanistic Insight into the Thermal Ring Opening of the Dewar Isomer of 1,2-Dihydro-1,2-azaborinines [0.03%]
1,2-二氢-1,2-氮杂硼inine的Dewar异构体的热环opening机理研究
Sonja M Biebl,Paul Ziemann,Markus Ströbele et al.
Sonja M Biebl et al.
In contrast to the multichannel photochemistry of benzene, 1,2-dihydro-1,2-azaborinines generally undergo a selective electrocyclic ring-closure reaction, yielding the corresponding Dewar (2-aza-3-borabicyclo[2.2.0]-hex-5-ene) isomers. The ...
Superoxide Anion-Dependent Mitochondrial Fission Contributes to Hippocampal Synaptic Dysfunction in Stress-Susceptible Mice [0.03%]
应激易感小鼠海马区超氧阴离子依赖的线粒体分裂参与了突触功能障碍
Xiwei Li,Xue Xue,Simiao Zhang et al.
Xiwei Li et al.
Reduced synaptic plasticity of hippocampal neurons is a core aspect of depression. Mitochondrial dysfunction affects the synaptic plasticity of neurons. However, the characteristics and molecular mechanisms of mitochondrial dysfunction in h...
Soft Ionic Materials: Design and Applications in Functional Electrochemical Systems [0.03%]
软离子材料：设计及功能电化学系统中的应用
Hyeon Woo Yang,Daniel Sanghyun Cho,Juyoung Kang et al.
Hyeon Woo Yang et al.
By integrating the rapid ionic transport of ionic liquids with the structural integrity of polymers, ionogels achieve high conductivity, mechanical flexibility, and environmental stability. These attributes position them as promising solid-...
Synthesis and Crystal Structure of Anhydrous Di-iodyl Carbonate (IO2)2[CO3], Hosting I5+-Cations [0.03%]
无水二碘酸盐碳酸酯(IO2)2[CO3]的合成及其晶体结构研究(含I5+阳离子)
Dominik Spahr,Lkhamsuren Bayarjargal,Lukas Brüning et al.
Dominik Spahr et al.
The anhydrous di-iodyl carbonate (IO2)2[CO3] has been synthesized in a laser-heated diamond anvil cell at 30(2) GPa and 1600(200) K by a reaction of I2O5 with CO2. Its monoclinic crystal structure (C2/c with Z = 4) was determined from synch...