Palladium(II)-Catalyzed Nondirected C(sp2)-H Alkoxycarbonylation of Arenes [0.03%]
钯催化芳烃非导向的碳氢酰氧基化反应
Simon Kaltenberger,Joshua Meinshausen,Jyotirmoy Dey et al.
Simon Kaltenberger et al.
Aromatic carboxylic acid derivatives are ubiquitous structural motifs in organic chemistry, which find widespread use as synthetic intermediates or target compounds for various applications. An ideal way to access these compounds is by C-H ...
Regioselective Glycosylation of Fluorine-18-Labeled Sorbitol for Enhanced Bacterial Detection In Vivo Using PET [0.03%]
体内使用PET检测细菌时利用放射性氟化甜酒糖苷进行区域选择性糖基化的研究
Sang Hee Lee,Jung Min Kim,Marina López-Álvarez et al.
Sang Hee Lee et al.
Precise and rapid detection of bacterial infection in vivo remains a significant challenge in clinical practice. In response to this challenge, several pathogen-specific positron emission tomography (PET) tracers have been developed, includ...
Harnessing Bone-Liver Crosstalk: A Dual-Action LYTAC Approach for Bone-Specific Accumulation and Liver-Specific Protein Degradation in Bone Disorders [0.03%]
利用骨肝信号通路：一种针对骨病的骨特异性聚集和肝特异性蛋白降解的双效LYTAC方法
Yuan Ma,Gubu Amu,Yufei Pan et al.
Yuan Ma et al.
Despite significant progress in extracellular targeted protein degradation (eTPD), existing approaches rarely achieved tissue-specific drug accumulation while maintaining efficient systemic clearance, a critical challenge in treating bone d...
Olefin Coupling Catalyzed by (Pybox)Os Complexes via Osmacyclopentane Intermediates: Comparison with Isoelectronic (Phebox)Ir [0.03%]
(pybox)Os配合物催化的烯烃偶联反应：经由奥斯麦环戊烷中间体与其他等电子的(Phebox)Ir配合物的比较
Ashish Parihar,Santanu Malakar,Soham Chakraborty et al.
Ashish Parihar et al.
(Pybox)Os is found to catalyze alkene hydrovinylation, effecting the dimerization of ethylene, tail-to-tail coupling of propene and 1-butene, and cross-coupling of ethylene with higher α-olefins. This reactivity contrasts with the previous...
A Perspective on Unintentional Fragments and Their Impact on the Dark Metabolome, Untargeted Profiling, Molecular Networking, Public Data, and Repository Scale Analysis [0.03%]
从暗代谢组、非目标分析、分子网络、公共数据集和大数据角度重新审视非故意产生的碎片离子及其影响
Yasin El Abiead,Ipsita Mohanty,Shipei Xing et al.
Yasin El Abiead et al.
In/postsource fragments (ISFs) arise during electrospray ionization or ion transfer in mass spectrometry when molecular bonds break, generating ions that can complicate data interpretation. Although ISFs have been recognized for decades, th...
Orbital-Selective Photoinduced Polaron Dynamics in Na2O2: Ultrafast Asymmetric Charge Transport Modulation in Sodium-Air Batteries [0.03%]
钠氧电池中纳氧阴离子轨道选择型光致极化动力学研究
Haoran Lu,Qiu Fang,Wei-Hai Fang et al.
Haoran Lu et al.
Understanding and controlling polaron dynamics are pivotal for improving charge transport in sodium-air batteries. Here, we employ real-time time-dependent density functional theory to investigate the ultrafast photoinduced dynamics of hole...
Mitigating Challenges of the Neutral Oxygen Evolution Reaction: The Undervalued Importance of Electrolyte Engineering [0.03%]
中性氧析出反应面临的挑战及电解液工程的潜在价值
Erica D Clinton,Juliana Bruneli Falqueto,Thomas J Schmidt et al.
Erica D Clinton et al.
Water splitting in quasi-neutral electrolytes (5 ≤ pH ≤ 10) offers advantages over highly alkaline or acidic electrolytes by improving operational safety, simplifying maintenance, and enabling the use of diverse natural water sources. Suc...
Nanoamplifier Agents Transiently Rise the Metabolism of β‑Amyloid Peptide in Urine for the Early Diagnosis of Alzheimer's Disease [0.03%]
纳米放大剂可使尿液中β-淀粉样肽代谢物水平暂时性升高用于阿尔茨海默病的早期诊断
Yun Zhao,Enpeng Xi,Ziwei Wang et al.
Yun Zhao et al.
Alzheimer's disease (AD) is the most common form of dementia without effective treatment. Therefore, early diagnosis for timely treatment and delayof the onset of AD are critical. At present, detecting β-amyloid (Aβ) in cerebrospinal flui...
Carbene Addition and Its Remote Influence on Dy···Dy Coupling, Relaxation of Magnetization, and Magnetic Frustration in Fullerene Single-Molecule Magnets [0.03%]
卡宾加成及其对富勒烯单分子磁体中铁铁耦合、磁化强度弛豫和磁滞的竞争的远距离影响
Matheus Felipe de Souza Barbosa,Wei Yang,Noel Israel et al.
Matheus Felipe de Souza Barbosa et al.
Magnetic properties of lanthanide endohedral metallofullerenes are strongly modulated by intramolecular metal-metal interactions, which suppress the quantum tunneling of magnetization (QTM) in Dy2ScN@C80, but lead to magnetic frustration wi...
Mycobacteriophage Functionalized Magnetic Nanocrystal Clusters for Highly Sensitive and Rapid Detection of Mycobacterium tuberculosis [0.03%]
用于高灵敏快速检测结核分枝杆菌的分枝杆菌噬菌体功能化磁性纳米晶簇
Zhen Xiao,Charles Yen,Ting Wang et al.
Zhen Xiao et al.
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is one of the most dangerous diseases globally. Mtb poses a heavy death toll, especially in low-resource settings, where inadequate diagnostic capabilities greatly hinder treatment and...