Is Cobalt Joining the σ‑/π-Hole Crown? Exploring Noncovalent Interactions in Cobalamin [0.03%]
钴在σ-/π-穴王冠中吗？探讨维生素B12中的非共价相互作用
Sergi Burguera,Antonio Bauzá
Sergi Burguera
Herein, the σ-/π-hole chemistry of Co within a biological framework was computationally studied for the first time using Cobalamin (Cbl) as a case study. Starting with a Protein Data Bank (PDB) survey, 111 structures involving Cbl were fo...
Unprecedented Carbon-like Nanomaterials and Bandgap-Engineered Perovskites from an Octet-Rule-Derived ONa6 Supercarbon Building Block [0.03%]
源自八隅体规则的ONa6超碳构建单元的前所未有的类石墨烯纳米材料及能隙可调控钙钛矿型材料
Jun Li,Shi-Jun Wang,Shi-Hu Du et al.
Jun Li et al.
The rational design of superatomic architectures mimicking carbon's versatility remains a fundamental challenge yet holds promising potential for programmable quantum materials and functional devices. Herein, an octet-rule-derived open-shel...
Atomically Precise Metal Nanoclusters for Bioimaging and Therapy: Progress and Perspectives [0.03%]
原子精确金属纳米团簇在生物成像和治疗中的进展与前景
Tingting Xu,Beibei Xiang,Yu Chen et al.
Tingting Xu et al.
Nanomaterials that simultaneously possess bioimaging and therapeutic functions along with excellent biocompatibility have long been pursued for early disease detection as well as precise therapy, which is critical for enhancing the cure rat...
Correction to "Effect of Sulfonation Level on the Percolated Morphology and Proton Conductivity of Hydrated Fluorine-Free Copolymers: Experiments and Simulations" [0.03%]
有关“磺化度对脱氟共聚物渗滤态形貌和质子导电性的影响：实验与模拟”的勘误通知
Sol Mi Oh,Victoria S Lee,William F Drayer et al.
Sol Mi Oh et al.
[This corrects the article DOI: 10.1021/jacsau.5c00218.]. © 2025 The Authors. Published by American Chemical Society.
Published Erratum
JACS Au. 2025 Sep 17;5(10):5233. DOI:10.1021/jacsau.5c01145 2025
Merging Central and Axial Chirality in Cyclic(alkyl)(amino)carbenes: The Keystone for High Enantioselectivities in Ru-Catalyzed Asymmetric Olefin Metathesis [0.03%]
环烷基胺卡宾中的中央手性和轴手性兼备：钌催化烯烃不对称元-assigned反应高对映选择性的关键因素
Meng Liu,Dylan Bouëtard,Jakub Talcik et al.
Meng Liu et al.
A series of 38 chiral ruthenium complexes containing cyclic-(alkyl)-(amino)-carbene (CAAC) ligands with axial C-N chirality have been developed. By merging axial and central chirality, very high enantioselectivity (up to >99% ee) as well as...
The Unique Properties and Click Capacity of the Tetrazine Group Enable Tetrazine Allyl Acetate to Serve as a Versatile Bis-Thiol Bioconjugation and Functionalization Agent [0.03%]
四氮唑基团的独特性质和反应活性使其衍生物能够作为双硫化物生物偶联及功能化试剂
Hang Xu,Mengyang Chang,Yue Dong et al.
Hang Xu et al.
The inverse electron demand Diels-Alder (IEDDA) click reaction of tetrazine (Tz) with trans-cyclooctene (TCO), which takes place at an exceptionally high rate, has excellent orthogonality and biocompatibility. As a result, the unrivaled cap...
Discovery of Unprecedented Arylation Coupling Cyclopeptide Inspires Natural Product-like Antitubercular Lead Compounds [0.03%]
一类前所未有的芳基化环肽的发现及新型抗结核药物分子样式的启示
Qun Zhang,Wei-Feng Xu,Qian-Qian Jing et al.
Qun Zhang et al.
Tuberculosis (TB) remains one of the world's deadliest communicable diseases. Naturally derived antibiotics appear frequently in nature as collections of structurally similar compounds representing an adaptive evolutionary response to drug ...
Algorithm-Assisted Structure Identification of Individual Nucleobases in Single DNA Chains through Tip-Enhanced Raman Spectromicroscopy [0.03%]
基于针尖增强拉曼光谱的单DNA链碱基结构鉴定算法
Lu-Yao Zhu,Yu Han,Yu-Fan Zhang et al.
Lu-Yao Zhu et al.
The functions of biomolecules such as DNA are not only determined by their sequences but also strongly dependent on their stereostructures and geometric configurations of constituent units. However, most DNA sequencing techniques developed ...
Engineering Lanthanide Ion-Labeled Aptamers for ICP-MS Profiling of Serum-Derived Extracellular Vesicles from Colorectal Cancer [0.03%]
工程化镧系离子标记的适配体用于结直肠癌患者血清衍生外泌体的ICP-MS检测分析研究
Yawei Feng,Cong Luo,Yunshan Yang et al.
Yawei Feng et al.
Membrane proteins on extracellular vesicles (EVs) derived from clinical serum samples have emerged as promising biomarkers for cancer screening, early diagnosis and prognosis. However, high-throughput profiling of multiple EV proteins with ...
HU Searches and Binds Specific DNA via a Multistep Process Combining Weak Electrostatic Binding, Protein Reorientation, and DNA Flexibility [0.03%]
HU通过多步过程结合特定DNA，该过程结合了弱静电结合、蛋白质重新定向和DNA的柔韧性
Elliot W Chan,Mark C Leake,Agnes Noy
Elliot W Chan
Despite their limited resolution, coarse-grained simulations have been the chosen method to obtain mechanistic information regarding the process of protein binding to DNA. Here, we demonstrate that state-of-the-art atomic simulations can ca...