Continuous-Flow Synthesis of the Fungicide Tetraconazole: Unprecedented Selectivity in Aldol Condensation and Mechanistic Insights via In-Line 200 MHz 1H NMR [0.03%]
fungicide tetracon唑的连续流动合成：醛缩合选择性的新进展以及通过在线200MHz 1H NMR的机理见解
Masahiro Sasaya,Haruro Ishitani,Shu̅ Kobayashi
Masahiro Sasaya
Continuous manufacturing offers a sustainable and flexible approach for fine chemical production, yet its application to complex agrochemicals like tetraconazole remains largely unexplored. Herein, we report the first continuous-flow synthe...
Temperature-Responsive Supramolecular Chiral Switch Achieved by Macrocyclic Confinement [0.03%]
大环约束下实现的温度响应型超分子手性开关
Xuan Zhao,Shuangqi Song,Hengzhi Zhang et al.
Xuan Zhao et al.
A series of tunable morphological nanoaggregates are constructed by hydroxypropyl-β/γ-cyclodextrin (HPβ/γCD) and cucurbit[8]-uril (CB[8]), respectively, encapsulating phenylalanine dipeptide-modified pyrene (PFF) based on host-guest com...
Shunt Pt/FeO x ‑Al2O3 Catalysts for SO2‑Tolerant CO Oxidation [0.03%]
用于SO2耐受型CO氧化的载流子Pt/FeO x -Al2O3 催化剂
Shaozhen Shi,Xuefeng Chu,Tao Gan et al.
Shaozhen Shi et al.
Sulfur, particularly SO2, remains one of the primary poisons in catalytic systems for treating exhaust gases. Currently, the elimination of CO is still challenging in the presence of SO2 at low temperatures (
NADH-Triggered Photogenerated Carbon Radicals as General Abstracting Agents for Synergism of Apoptosis and Ferroptosis [0.03%]
NADH触发的光生成碳自由基作为一般抽象剂以实现凋亡和铁死亡的协同作用
Xing Zeng,Kang-Kang Yu,Hong Zhang et al.
Xing Zeng et al.
Free radicals, with their high reactivity, offer a promising strategy for tumor treatment by effectively circumventing drug resistance. Free-radical-based cancer therapies include radiotherapy, chemotherapy, and emerging approaches such as ...
Aptamer-Mediated Covalent Dual Lysosome-Targeting Chimeras Enhance Targeted Degradation of Cell Surface Proteins [0.03%]
用于靶向降解细胞表面蛋白的适配体介导的共价双定位联结体增强作用
Tao Peng,Min Su,Zuying Zhang et al.
Tao Peng et al.
Aptamer-based lysosome-targeting chimeras (Apt-LYTACs) have emerged as a promising strategy for the selective degradation of cell surface proteins by linking a target-specific aptamer to a lysosome-trafficking receptor ligand. However, thei...
Proteomic Profiling of Oxidative Stress Response Proteins with a Methionine Sulfoxide-Inspired Activity-Based Probe [0.03%]
基于甲硫氨酸亚砜的活性分子探针的氧化压力响应蛋白质组学分析
Seungmin Ahn,Jung-Min Kee
Seungmin Ahn
Methionine oxidation is a key hallmark of cellular oxidative stress, which is reversed by methionine sulfoxide reductases (Msrs) as part of cellular defense mechanisms. Current tools for studying methionine oxidation and Msr function rely o...
Microwave-Assisted Thioester-Empowered Toolkit for Modular Glycopeptide Synthesis [0.03%]
用于模块化糖肽合成的硫酯赋能微波工具箱
Yue Yang,Miaomiao Zhang,Meng-Hai Xiang et al.
Yue Yang et al.
Glycopeptides and glycoproteins with structural precision are valuable for functional studies and applications. Conventional couplings of glycosyl amino acids are slow, wasteful, and impractical for broad use. To address the fundamental syn...
Phosphorylation of α‑Synuclein Fibrils at S129 Changes DNAJB1 Binding as Probed by Solid-State NMR [0.03%]
固体核磁共振检测到α-突触核蛋白S129位点磷酸化改变了DNAJB1的结合方式
Sayuri Pacheco,Dhanya S Reselammal,Shanlong Li et al.
Sayuri Pacheco et al.
Amyloid fibrils formed by the protein α-synuclein are implicated in the pathogenesis of synucleinopathies. In addition to their rigid cross-β core, these fibrils have intrinsically disordered regions on their surface, which are important ...
Highly Pure Combinatorial Peptide Libraries by Resin-Enabled Catch and Release [0.03%]
基于树脂的捕获与释放技术合成高纯度肽组合库
Quan Zuo,Jie Yan,Hongyi Huang et al.
Quan Zuo et al.
For peptide-drug conjugate (PDC) development, high-quality peptide ligands with easy functionalization are essential. Combinatorial chemical peptide libraries are key for discovering high-affinity non-natural ligands, yet their utility has ...
Deep-Sea Genome Mining Reveals Cooperative ATP-Grasp Ligase-Directed Biosynthesis of Pentacyclic Myxomiditides with Potent Protease Inhibition [0.03%]
深海基因组测序揭示了五环链霉菌霉素的协同ATP-草酰辅酶A结合结构酶指导生物合成及其潜在的蛋白酶抑制作用
Yueqian Li,Jieni Wang,Zhengan Zhang et al.
Yueqian Li et al.
Microviridins are ribosomally synthesized and post-translationally modified peptides, typically featuring a conserved tricyclic structure formed by two ATP-grasp ligases. However, the diversity and evolution of these enzymes remain incomple...