Late-Stage Functionalization of Lysine to Organelle-Targeting Fluorescent Probes [0.03%]
用于靶向细胞器的荧光探针的赖氨酸后期功能化
Patricia Rodriguez,Ankita Misra,Monika Raj
Patricia Rodriguez
The late-stage functionalization of peptides presents a promising avenue for expanding their chemical diversity and properties, particularly in the realm of drug discovery. Herein, we present a powerful late-stage functionalization (LSF) st...
Ru(II) Complex-Mediated Phase Separation Amplifies Photocatalytic RNA Damage to Stimulate RIG‑I Immunotherapy [0.03%]
基于Ru(II)的相分离放大全光催化RNA损伤以激活RIG-I免疫疗法
Xiao-Xiao Chen,Xia Mu,Zhi-Yuan Li et al.
Xiao-Xiao Chen et al.
Phase separation is closely related to the transcription, processing, translation, and metabolism of RNA, and regulating RNA phase separation may serve as an effective antitumor strategy. However, small molecule-based RNA phase separation i...
Miquel Navarro,Louise Delaurenti,Alejandra Pita-Milleiro et al.
Miquel Navarro et al.
Gold-(I) carbenes, defined as [LAuCR2]+, are key intermediates in catalysis. Their isolation is challenging due to the high electrophilic character of the carbene that cannot be tempered solely by π-backdonation from gold. Among those, t...
Designing Nanoparticle Surfaces with DNA Barcodes for Accurate In Vivo Quantification [0.03%]
设计带有DNA条形码的纳米粒子表面以实现精确的体内定量
Ayokunle A Lekuti,Vanessa Y C Li,Ayden Malekjahani et al.
Ayokunle A Lekuti et al.
DNA barcoding is a common method for identifying the biodistribution of nanoparticles. DNA barcodes are typically encapsulated within nanoparticles to ensure accurate measurements by next-generation sequencing. This method limits the types ...
Hidden Carbenes: NHC-Al Species at the Al2O3-Ionic Liquid Interface [0.03%]
隐藏的卡宾：Al₂O₃-离子液体界面处的NHC-Al物种
Muhammad I Qadir,Camila P Ebersol,Blendo A da Silva et al.
Muhammad I Qadir et al.
The modification of the surface chemistry of heterogeneous catalysts/supports alters their electronic and catalytic properties, particularly through the incorporation of a monolayer of sophisticated N-heterocyclic carbenes (NHCs). However, ...
Modular Access to Quaternary α‑Cyano Carbonyl Compounds via NiH Catalysis [0.03%]
镍氢催化下四级α-氰基羰基化合物的模块化获取方法研究
Yoonho Lee,Yujin Jung,Seonhwa Choo et al.
Yoonho Lee et al.
Quaternary α-cyano carbonyl compounds are an important class of molecules in organic synthesis due to their versatility as precursors to essential building blocks and their potential applications in pharmaceutical synthesis. Despite the im...
Bioinspired Synthesis of Bridged Isochromane Fused Pyrazoles by a Silver Catalyzed Cascade Reaction and Its Application for Antibacterial Activity [0.03%]
受生物启发的桥联异色满并吡唑类衍生物的银催化串联反应合成及其抗菌活性研究
Bhuvnesh Singh,Shreya Tewari,Manleen Kaur et al.
Bhuvnesh Singh et al.
A stereoselective silver catalyzed one pot vinylogous aldol addition followed by a cascade [4+2] cycloaddition reaction of α-arylidene pyrazolinones to in situ generated isochromenylium ions has been developed, which provides an unpreceden...
Arrested Cooperative Electron Transfer by Stabilization of a Long-Lived Confined Unpaired Electron [0.03%]
通过稳定长寿命局部长程无配对电子而抑制的协同电子转移
Cheriehan Hessin,Mokhtar Ben Ghanem,Nolwenn Le Breton et al.
Cheriehan Hessin et al.
Cooperative multielectron transfer is central to electron storage strategies and small-molecule activation and involves a thermodynamically favored second electron transfer occurring after the first electron transfer. This is the trademark ...
Unraveling the Catalytic Mechanism and Substrate Selectivity of HDAC10: A Dual-Filter Approach for Polyamine Deacetylation [0.03%]
揭示HDAC10催化机制及其底物选择性：一种针对多元胺去乙酰化的双重过滤方法
Shengyang Cai,Jingwei Weng,Igor Ying Zhang et al.
Shengyang Cai et al.
The histone deacetylase (HDAC) family plays a crucial role in regulating acetylation-dependent cellular processes, with dysregulation linked to diseases ranging from cancer to neurodegeneration. HDAC10, the sole polyamine deacetylase in the...
Modular Synthesis of Substituted Lactams via a Deoxygenative Photochemical Alkylation-Cyclization Cascade of Secondary Amides in Flow [0.03%]
流动化学中二级酰胺的脱氧光化学烷基化-环化串联反应在杂环化合物合成中的应用研究
Damiano Diprima,Thomas Terp Paulsen,Antonio Pulcinella et al.
Damiano Diprima et al.
γ-Lactams are crucial scaffolds in many bioactive compounds and pharmaceutical agents, yet their synthesis featuring diverse γ- and N-substitution remains a significant synthetic challenge. Current methods often lack modularity and effici...