Katharina Oelschlegel,Myron Heinz,Sandipan Maji et al.
Katharina Oelschlegel et al.
Direct hydrogenation of N2 at ambient conditions lags behind the recent advances in molecular N2 (electro-)-fixation. In fact, molecular platforms that couple N2 and H2 activation remain rare. Inspired by recent photocatalytic approaches, w...
Molecular Armor Encapsulation of Practical Layered Cathode Empowers Energetic Ah-Level Zn-MnO2 Pouch and Prismatic Cells [0.03%]
实用层状阴极分子装甲封装赋能高能安时级锌锰 dioxide 软包和方型电池
Xinhua Zheng,Bibo Han,Shanjie Cheng et al.
Xinhua Zheng et al.
The development of energetic zinc-manganese oxide (Zn-MnO2) pouch and prismatic cells for energy storage applications is highly required, yet remains challenging especially in their Ah-level. To bridge the gap between laboratory-scale studi...
Mutual Enhanced Dynamic Interactions among Three Intrinsically Disordered Proteins [0.03%]
三个内在无序蛋白间的互惠动态相互作用
Shi Yu,Tingting Li,Zhijun Liu et al.
Shi Yu et al.
The intrinsically disordered C-terminal domain (CTD) of the 4.1 proteins functions as a modular hub for interactions with diverse binding partners. Previous research has demonstrated that 4.1G-CTD associates with an intrinsically disordered...
Perfluoro- tert-butoxylated Monosaccharides for Metabolic 19F Magnetic Resonance Imaging in Hepatocellular Carcinoma Detection [0.03%]
用于检测肝细胞癌的代谢型19F磁共振成像的全氟叔丁氧基单糖类分子
Yu Li,Hanxiong Long,Pei He et al.
Yu Li et al.
Fluorine-19 magnetic resonance imaging (19F MRI) holds promise for noninvasive cancer diagnosis due to its negligible background signal, quantitative capability, radiation-free nature, and unlimited tissue penetration. However, its applicat...
Vibrational Energy Dissipation in Noncontact Single-Molecule Junctions Governed by Local Geometry and Electronic Structure [0.03%]
局域几何和电子结构决定的非接触单分子结中的振动能量耗散
Lukas Hörmann,Reinhard J Maurer
Lukas Hörmann
The vibrational dynamics of adsorbate molecules in single-molecule junctions depend critically on the geometric structure and electronic interactions between the molecule and the substrate. Vibrations, excited mechanochemically or by extern...
De Novo Design of High-Performance Sec-type Signal Peptide via a Hybrid Deep Learning Architecture [0.03%]
基于混合深度学习架构的高性能Sec型信号肽从头设计
Xiao-Peng Dai,Xiang-Chun Meng,Ying-Jun Zhou et al.
Xiao-Peng Dai et al.
The rational design of signal peptides represents a fundamental bottleneck in biotechnology, where sequence optimization directly governs protein secretion efficiency and industrial scalability. Current approaches rely predominantly on natu...
Synthesis of m, n‑Diaza[ n]helicenes via Skeletal Editing of Indeno[2,1‑ c]fluorene-5,8-diols [0.03%]
通过吲哚并[2,1-c]荧蒽二醇的结构编辑合成m,n-二氮杂[n]螺旋化合物
Marina Degač,Lena Reininger,Hanna Schardax et al.
Marina Degač et al.
Skeletal editing of 5-membered carbocycles to 6-membered heteroaromatic compounds represents an attractive concept that would enable late-stage heteroarene construction. However, the current state of the art does not offer many synthetic st...
Cu-Catalyzed Asymmetric Carbene Insertion into N-H, O-H, and S-H Bonds: Challenging the Existing Mechanistic Dogma [0.03%]
铜催化不对称卡宾插入N-H,O-H和S-H键反应：挑战传统机理理论
Arushi Tyagi,Kriti Gupta,Garima Jindal
Arushi Tyagi
A comprehensive mechanistic study of asymmetric carbene insertion into N-H, O-H, and S-H bonds catalyzed by Cu-spiroBox is presented. We challenge the currently widely accepted mechanism involving Cu-enolate intermediates that has dominated...
Switchable High-Valent Ag3+/Ag+ Redox Pair Stabilized in Polyoxometalate as Highly Oxidative "Electron Shuttle" Catalysts [0.03%]
可在多金属氧酸盐中稳定化的可切换高氧化态银红氧化学体系作为高效的“电子穿梭”催化剂
Xiang Li,Hehua Hui,Yuanhang Ren et al.
Xiang Li et al.
We report the isolation and characterization of the first example of a crystallized high-valent Ag3+-containing polyoxometalate (POM) complex, Cs7K4[P2W19AgIIIO69(OH2)]·17H2O (1), as a "catalyst bearing catalyst" capable of catalyzing the ...
An Orally Administered Misuse Deterrent Opioid Prodrug for Treatment of Acute Pain [0.03%]
一种用于治疗急性疼痛的口服滥用防护型阿片类药物前药
Douglas A Rose,Joseph W Treacy,Karina Seth et al.
Douglas A Rose et al.
Opioids are a powerful class of medicines due to their ability to alleviate acute pain. However, the use of prescription opioids has led to an epidemic in the United States. Many efforts to combat this are ongoing, including the preparation...