Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules [0.03%]
慢性阻塞性肺疾病的血浆代谢特征及其遗传变异对表型驱动模块的影响
Lucas A Gillenwater,Katherine A Pratte,Brian D Hobbs et al.
Lucas A Gillenwater et al.
Background: Small studies have recently suggested that there are specific plasma metabolic signatures in chronic obstructive pulmonary disease (COPD), but there have been no large comprehensive study of metabolomic signatures in COPD that a...
Integrative Data Analytic Framework to Enhance Cancer Precision Medicine [0.03%]
一种增强癌症精准医学的集成数据分析框架
Thomas Gaudelet,Noël Malod-Dognin,Nataša Pržulj
Thomas Gaudelet
With the advancement of high-throughput biotechnologies, we increasingly accumulate biomedical data about diseases, especially cancer. There is a need for computational models and methods to sift through, integrate, and extract new knowledg...
On the Consistency between Gene Expression and the Gene Regulatory Network of Corynebacterium glutamicum [0.03%]
谷氨酸棒状杆菌基因表达与基因调控网络的协调一致性分析
Doglas Parise,Mariana Teixeira Dornelles Parise,Evans Kataka et al.
Doglas Parise et al.
Background: Transcriptional regulation of gene expression is crucial for the adaptation and survival of bacteria. Regulatory interactions are commonly modeled as Gene Regulatory Networks (GRNs) derived from experiments such as RNA-seq, micr...
Massimiliano Zanin,Nadim A A Aitya,José Basilio et al.
Massimiliano Zanin et al.
Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated ...
Informatics Inference of Exercise-Induced Modulation of Brain Pathways Based on Cerebrospinal Fluid Micro-RNAs in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [0.03%]
基于脑脊液微RNAs的肌痛性脑脊髓炎/慢性疲劳综合征运动诱导的脑通路调节的计算推断
Vaishnavi Narayan,Narayan Shivapurkar,James N Baraniuk
Vaishnavi Narayan
Introduction: The post-exertional malaise of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) was modeled by comparing micro-RNA (miRNA) in cerebrospinal fluid from subjects who had no exercise versus submaximal exercise. Materia...
CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19 [0.03%]
基于网络医学的COVID-19蛋白质、疾病、药物和症状整合研究CovMulNet19
Nina Verstraete,Giuseppe Jurman,Giulia Bertagnolli et al.
Nina Verstraete et al.
Introduction: We introduce in this study CovMulNet19, a comprehensive COVID-19 network containing all available known interactions involving SARS-CoV-2 proteins, interacting-human proteins, diseases and symptoms that are related to these hu...
Multiple Sclerosis Atlas: A Molecular Map of Brain Lesion Stages in Progressive Multiple Sclerosis [0.03%]
多发性硬化症图谱：进行性多发性硬化症脑损伤阶段的分子图
Tobias Frisch,Maria L Elkjaer,Richard Reynolds et al.
Tobias Frisch et al.
Introduction: Multiple sclerosis (MS) is a chronic disorder of the central nervous system with an untreatable late progressive phase. Molecular maps of different stages of brain lesion evolution in patients with progressive multiple scleros...
Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine [0.03%]
网络与系统医学：欧洲科学技术行动关于开放多尺度系统医学的立场文件
Blandine Comte,Jan Baumbach,Arriel Benis et al.
Blandine Comte et al.
Introduction: Network and systems medicine has rapidly evolved over the past decade, thanks to computational and integrative tools, which stem in part from systems biology. However, major challenges and hurdles are still present regarding v...
Combining Gene-Disease Associations with Single-Cell Gene Expression Data Provides Anatomy-Specific Subnetworks in Age-Related Macular Degeneration [0.03%]
结合基因疾病关联和单细胞基因表达数据可提供与年龄相关黄斑变性的组织特异性亚网络
Philip J Luthert,Christina Kiel
Philip J Luthert
Background: Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. Despite some treatment options for late AMD, there is no intervention that blocks early AMD proceeding to the late and ...
Educational and Ethical Considerations for Genetic Test Implementation Within Health Care Systems [0.03%]
医疗保健系统中基因检测实施的教育和伦理问题考虑
Emma Kurnat-Thoma
Emma Kurnat-Thoma
Introduction: The precision medicine (PM) era presents unprecedented proliferation of genetic/genomic initiatives, information, and bioinformatic tools to enhance targeted molecular diagnosis and therapeutic treatments. As of February 29, 2...