Manned space travel: from a race between nations to a race against the environmental stressors beyond earth [0.03%]
载人航天：从国家之间的竞争到应对地球之外环境压力的竞争
Marjan Boerma,Igor Koturbash
Marjan Boerma
Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation [0.03%]
低剂量高线性能量传递辐射暴露大鼠血浆的纵向代谢改变
Tixieanna Dissmore,Andrew G DeMarco,Meth Jayatilake et al.
Tixieanna Dissmore et al.
Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, l...
Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation [0.03%]
低剂量氧离子辐射小鼠模型的短期代谢紊乱研究
Michael Girgis,Yaoxiang Li,Meth Jayatilake et al.
Michael Girgis et al.
Molecular alterations as a result of exposure to low doses of high linear energy transfer (LET) radiation can have deleterious short- and long-term consequences on crew members embarking on long distance space missions. Oxygen ions (16O) ar...
Catherine M Davis,Antiño R Allen,Dawn E Bowles
Catherine M Davis
Staying longer in outer space will inevitably increase the health risks of astronauts due to the exposures to galactic cosmic rays and solar particle events. Exposure may pose a significant hazard to space flight crews not only during the m...
Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models [0.03%]
暴露于铅时线粒体解偶联蛋白2通过异质性核糖核酸颗粒蛋白K调节
Gaochun Zhu,Qian Zhu,Wei Zhang et al.
Gaochun Zhu et al.
Synaptic plasticity plays an important role in learning and memory in the developing hippocampus. However, the precise molecular mechanism in lead exposure models remains to be studied. UCP2, an inner mitochondrial anion carrier, regulates ...
Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity [0.03%]
用于评估药物和化学物质所致肝毒性的CYP过表达HepG2细胞的特征分析
Si Chen,Qiangen Wu,Xilin Li et al.
Si Chen et al.
Hepatic metabolism catalyzed by the cytochrome P450 (CYP) superfamily affects liver toxicity associated with exposures to natural compounds and xenobiotic agents. Previously we generated a battery of HepG2-derived stable cell lines that ind...
Blanka Tariba Lovaković,Tanja Živković Semren,Toni Safner et al.
Blanka Tariba Lovaković et al.
Disruption of element homeostasis may contribute to increased susceptibility of men to cancer development. Whether environmental low-level metal exposure could contribute to the pathogenesis of testicular cancer is unknown. Comparison of th...
Three dimensional graphene materials doped with heteroatoms for extraction and adsorption of environmental pollutants in wastewater [0.03%]
用于提取和吸附废水环境中污染物的掺杂异原子的三维石墨烯材料
Zhiyong Guo,Yufeng Feng,Chen Zhang et al.
Zhiyong Guo et al.
Environmental pollution by heavy metal ions, organic pollutants, oils, pesticides or dyes is a ubiquitous problem adversely affecting human health and environmental ecology. Development and application novel adsorbents in full-scale treatme...
Ruth Nabwire Wangia-Dixon,Kizito Nishimwe
Ruth Nabwire Wangia-Dixon
Fumonisins, discovered in 1988 are a group of naturally occurring toxins produced by fusarium pathogenic fungi. Besides their presence in animal feeds, contamination of human foods such as corn, millet, oats, rye, barley, wheat and their pr...
Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine [0.03%]
抗试剂检测 retrorsine 处理的小鼠肝蛋白中赖氨酸修饰的状态
Ting Cheng,Weiwei Li,Xiaojing Yang et al.
Ting Cheng et al.
Many pyrrolizidine alkaloids (PAs), an important class of natural products, are hepatotoxic and carcinogenic. Increased attention has been paid to PA poisoning cases worldwide. Generally, most PAs themselves are not toxic. However, reactive...