Trace elements exposure and risk in age-related eye diseases: a systematic review of epidemiological evidence [0.03%]
与年龄相关的眼病的微量元素暴露及风险：流行病学证据的系统性回顾
Onyinyechi Bede-Ojimadu,Chinna N Orish,Beatrice Bocca et al.
Onyinyechi Bede-Ojimadu et al.
This systematic review aimed to evaluate existing evidence on the associations between trace elements exposure and age-related eye diseases. PubMed and Google scholar databases were searched for epidemiological and postmortem studies on the...
A descriptor-based analysis to highlight the mechanistic rationale of mutagenicity [0.03%]
基于描述符的分析方法揭示致突变性机理的假说
Domenico Gadaleta,Emilio Benfenati
Domenico Gadaleta
Cancer is a main concern for human health and there is a need of alternative methodologies to rapidly screen large quantitative of compounds that may represent a toxicological risk. Here a statistical analyses is performed on a benchmark da...
Everything you wanted to know about space radiation but were afraid to ask [0.03%]
你想知道却害怕问的太空辐射那些事儿
Jeffery Chancellor,Craig Nowadly,Jacqueline Williams et al.
Jeffery Chancellor et al.
The space radiation environment is a complex combination of fast-moving ions derived from all atomic species found in the periodic table. The energy spectrum of each ion species varies widely but is prominently in the range of 400-600 MeV/n...
The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes [0.03%]
空间辐射和微重力对生物系统及功能的单一和综合影响研究进展
Jeffrey S Willey,Richard A Britten,Elizabeth Blaber et al.
Jeffrey S Willey et al.
Both microgravity and radiation exposure in the spaceflight environment have been identified as hazards to astronaut health and performance. Substantial study has been focused on understanding the biology and risks associated with prolonged...
Manned space travel: from a race between nations to a race against the environmental stressors beyond earth [0.03%]
载人航天：从国家之间的竞争到应对地球之外环境压力的竞争
Marjan Boerma,Igor Koturbash
Marjan Boerma
Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation [0.03%]
低剂量高线性能量传递辐射暴露大鼠血浆的纵向代谢改变
Tixieanna Dissmore,Andrew G DeMarco,Meth Jayatilake et al.
Tixieanna Dissmore et al.
Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, l...
Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation [0.03%]
低剂量氧离子辐射小鼠模型的短期代谢紊乱研究
Michael Girgis,Yaoxiang Li,Meth Jayatilake et al.
Michael Girgis et al.
Molecular alterations as a result of exposure to low doses of high linear energy transfer (LET) radiation can have deleterious short- and long-term consequences on crew members embarking on long distance space missions. Oxygen ions (16O) ar...
Catherine M Davis,Antiño R Allen,Dawn E Bowles
Catherine M Davis
Staying longer in outer space will inevitably increase the health risks of astronauts due to the exposures to galactic cosmic rays and solar particle events. Exposure may pose a significant hazard to space flight crews not only during the m...
Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models [0.03%]
暴露于铅时线粒体解偶联蛋白2通过异质性核糖核酸颗粒蛋白K调节
Gaochun Zhu,Qian Zhu,Wei Zhang et al.
Gaochun Zhu et al.
Synaptic plasticity plays an important role in learning and memory in the developing hippocampus. However, the precise molecular mechanism in lead exposure models remains to be studied. UCP2, an inner mitochondrial anion carrier, regulates ...
Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity [0.03%]
用于评估药物和化学物质所致肝毒性的CYP过表达HepG2细胞的特征分析
Si Chen,Qiangen Wu,Xilin Li et al.
Si Chen et al.
Hepatic metabolism catalyzed by the cytochrome P450 (CYP) superfamily affects liver toxicity associated with exposures to natural compounds and xenobiotic agents. Previously we generated a battery of HepG2-derived stable cell lines that ind...