Protective effects of sitagliptin on methotrexate-induced nephrotoxicity in rats [0.03%]
西格列汀对甲氨蝶呤致大鼠肾毒性的保护作用
Leila Afkhami Fard,Hassan Malekinejad,Zeinab Esmaeilzadeh et al.
Leila Afkhami Fard et al.
Methotrexate (MTX), a cytotoxic chemotherapeutic and immunosuppressant agent, is widely used in the treatment of autoimmune diseases and different types of cancers. However, its use has been limited by its life-threatening side effects, inc...
Dietary exposure to thyroid disrupting chemicals: a community-based study in Canada [0.03%]
加拿大一项基于社区的甲状腺干扰化学品膳食暴露研究
Nicole Babichuk,Atanu Sarkar,Shree Mulay et al.
Nicole Babichuk et al.
The marine ecosystem around the Island of Newfoundland is contaminated by thyroid disrupting chemicals (TDCs). Coastal inhabitants may be exposed to TDCs through consumption of contaminated local seafood products and affecting thyroid funct...
Toxic and carcinogenic effects of hexavalent chromium in mammalian cells in vivo and in vitro: a recent update [0.03%]
六价铬的毒性及致癌性：最新的体内和体外哺乳动物细胞研究进展
Shehnaz Islam,Sreejata Kamila,Ansuman Chattopadhyay
Shehnaz Islam
Chromium VI (Cr (VI)) can cross cell membranes readily and causes the formation of Cr-DNA adducts, genomic damages, elevation of reactive oxygen species (ROS) and alteration of survival signaling pathways, as evidenced by the modulation in ...
Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure [0.03%]
基因33/Mig6/ERRFI1对六价铬诱导的人支气管上皮细胞转化的影响取决于暴露时间的长短
Cen Li,Dina Edeni,Sarah Platkin et al.
Cen Li et al.
Hexavalent chromium (Cr(VI)) compounds are environmental and occupational lung carcinogens. The present study followed the chronic effect of Cr(VI) on the neoplastic transformation of BEAS-2B lung bronchial epithelial cells with or without ...
Association between lower-level of environmental lead exposure and reactive and proactive aggression in youth: Sex differences [0.03%]
低水平环境铅暴露与青少年反应性攻击和主动性攻击之间的联系：性别差异
Andrea L Glenn,Yuli Li,Jianghong Liu
Andrea L Glenn
Lead exposure during childhood has been associated with a variety of negative outcomes, including antisocial/aggressive behavior. However, different subtypes of antisocial behavior have been found to have different neurobiological correlate...
Association between polychlorinated biphenyl exposure and thyroid hormones: a systematic review and meta-analysis [0.03%]
多氯联苯暴露与甲状腺激素之间的联系：系统评价和荟萃分析
Christine C Little,Joshua Barlow,Mathilda Alsen et al.
Christine C Little et al.
Purpose: To conduct a comprehensive meta-analysis investigating the association between polychlorinated biphenyl (PCB) exposure and serum thyroid hormone levels among adults. Methods: Eleven studies met inclusion criteria for analysis follo...
Applications of electron spin resonance spectroscopy in photoinduced nanomaterial charge separation and reactive oxygen species generation [0.03%]
电子自旋共振光谱在光诱导纳米材料载流子分离及活性氧生成过程中的应用研究
Xiumei Jiang,Mary D Boudreau,Peter P Fu et al.
Xiumei Jiang et al.
Nano-metals, nano-metal oxides, and carbon-based nanomaterials exhibit superior solar-to-chemical/photo-electron transfer properties and are potential candidates for environmental remediations and energy transfer. Recent research effort foc...
Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts [0.03%]
致癌吡咯里西啶生物碱和吡咯里西啶生物碱氮氧化物的代谢产物通过大鼠原代肝细胞产生相同的特征性DHP-DNA加合物
Xiaobo He,Qingsu Xia,Qiang Shi et al.
Xiaobo He et al.
We recently established a genotoxic mechanism mediated by a set of (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-DNA adducts, which lead to pyrrolizidine alkaloid (PA)-induced liver tumor initiation. This mechanism is invo...
Protective role of Spirulina platensis against glyphosate induced toxicity in marine mussel Mytilus galloprovincialis [0.03%]
螺旋藻对草甘膦诱导的海湾贻贝毒性的作用研究
Ouarghi Wided,Khazri Abdelhafidh,Mezni Ali et al.
Ouarghi Wided et al.
Glyphosate is a toxic environmental pollutant that has the ability to induce biochemical and physiological alterations in living organisms. Several studies have focused on the research of protective techniques against the stress induced by ...
Sub-acute exposure to Sudan IV-adulterated palm oil induces oxidative stress and represses the expression of Nrf2 and antioxidant genes in male albino rats [0.03%]
苏丹IV混伪杂劣棕榈油的次急性暴露诱导大鼠氧化应激及Nrf2和抗氧化基因表达下调
Ofem E Eteng,Ceaser A Moses,Emmanuel I Ugwor et al.
Ofem E Eteng et al.
This study investigated the effects of Sudan IV dye (S4D) on antioxidant biomarkers using palm oil adulterated with S4D. Thirty male albino rats were grouped into five (n = 6); Normal control, palm oil (PO), PO + S4D (100 mg/kg), PO + S4D (...