Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies [0.03%]
雌激素配体与雌激素受体相互作用的研究现状：功能及结合动力学研究综述
Jingwei Jin,Panpan Wu,Xinyue Zhang et al.
Jingwei Jin et al.
The investigation of estrogen actions and their interaction characteristics with estrogen receptors (ERs) to induce unique functional features inside cells have allowed us to understand better the regulation of many vital physiological and ...
Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes [0.03%]
谷胱甘肽和半胱氨酸对胎肝细胞中吡咯里西啶生物碱致肝毒性和DNA加合物形成的影响
Xiaobo He,Qingsu Xia,Qiang Shi et al.
Xiaobo He et al.
Pyrrolizidine alkaloids (PAs) are hepatotoxic, genotoxic, and carcinogenic phytochemicals. Upon metabolic activation, PAs produce dehydropyrrolizidine alkaloids (dehydro-PAs) as reactive primary pyrrolic metabolites. Dehydro-PAs are unstabl...
Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids [0.03%]
建立新型CYP3A4转染人肝窦状内皮细胞模型及其在吡咯里西啶生物碱肝毒性筛选中的应用
Yao Lu,Ka Yan Wong,Chunlai Tan et al.
Yao Lu et al.
Pyrrolizidine alkaloids (PAs) are extensively distributed in plants and are known to damage hepatic sinusoidal endothelial cells (HSECs) via metabolic activation mediated by hepatic cytochrome P450 enzymes (CYPs), particularly the CYP3A4 is...
Sentinel species for biomonitoring and biosurveillance of environmental heavy metals in Nigeria [0.03%]
尼日利亚环境重金属生物监测和生物预警的指示物种研究
Cecilia Nwadiuto Amadi,Chiara Frazzoli,Orish Ebere Orisakwe
Cecilia Nwadiuto Amadi
Nigeria receives copious annual precipitation to nourish its forests and agriculture, it has an extensive river drainage system, and it possesses valuable mineral deposits that stimulate both commercial and artisan mining activities. The co...
Ecological and toxicological manifestations of microplastics: current scenario, research gaps, and possible alleviation measures [0.03%]
微塑料的生态和毒性效应：现状、研究不足之处及可能的缓解措施
Amrik Bhattacharya,S K Khare
Amrik Bhattacharya
Microplastics (MPs) and associated contaminants have become a major environmental concern. From available literature, their ubiquitous presence is now well established. However, the kind and level of toxicological impacts these MPs accompli...
Inflammatory and immunological changes caused by noise exposure: A systematic review [0.03%]
噪声暴露引起的炎症和免疫学变化：系统性综述
Amirreza Abouee-Mehrizi,Yahya Rasoulzadeh,Tohid Kazemi et al.
Amirreza Abouee-Mehrizi et al.
Today, due to the growth of industries and spread of the use of various instruments and devices that produce high noise levels, it is necessary to pay more attention to the effects of exposure to noise on organs and tissues in the body. The...
Ascorbate exacerbates iron toxicity on intestinal barrier function against Salmonella infection [0.03%]
抗坏血酸通过加剧铁毒性损伤肠粘膜屏障功能促进沙门氏菌感染
Tengjiao Guo,Yisheng Yang,Jiayou Zhang et al.
Tengjiao Guo et al.
Ascorbic acid is often used to enhance iron absorption in nutritional interventions, but it produces pro-oxidant effects in the presence of iron. This study aimed to evaluate ascorbate's role in iron toxicity on intestinal resistance agains...