QPromoters: sequence based prediction of promoter strength in Saccharomyces cerevisiae [0.03%]
基于序列的启动子在酿酒酵母中的强度预测模型-QPromoter
Devang Haresh Liya,Mirudula Elanchezhian,Mukulika Pahari et al.
Devang Haresh Liya et al.
Promoters play a key role in influencing transcriptional regulation for fine-tuning the expression of genes. Heterologous promoter engineering has been a widely used concept to control the level of transcription in all model organisms. The ...
Jingli Liu,Tonia Hermon,Xiaohua Gao et al.
Jingli Liu et al.
Diabetes mellitus (DM) is an enormous public health issue worldwide. Recent data suggest that chronic arsenic exposure is linked to the risk of developing type 1 and type 2 DM, albeit the underlying mechanisms are unclear. This review discu...
Puzzling relationship between levels of toxic metals in blood and serum levels of reproductive hormones: Benchmark dose approach in cross-sectional study [0.03%]
毒金属血液水平与生殖激素血清水平关系的计量基准剂量评估方法：横断面研究
Ðurđica Marić,Katarina Baralić,Dragana Javorac et al.
Ðurđica Marić et al.
Reproductive disorders and infertility have become more common recently among the general population. Toxic metals are known as endocrine disruptors and as they are widespread in nature they may be linked to reproductive problems. This stud...
Genome scale CRISPR Cas9a knockout screen reveals genes that control glioblastoma susceptibility to the alkylating agent temozolomide [0.03%]
基于CRISPR-Cas9筛选的基因组规模的全基因敲除揭示了调控胶质母细胞瘤对烷化剂替莫唑胺敏感性的基因
Chidiebere U Awah,Jan Winter,Olorunseun O Ogunwobi
Chidiebere U Awah
Glioblastoma is the most fatal of all primary human brain tumors with 14 months median survival. The mainstay therapy for this tumor involves temozolomide, surgery, radiotherapy and tumor treating electric field. Cancer resistance to common...