Emily Chedrawe,Aditya Sathe,Josh White et al.
Emily Chedrawe et al.
Androgen deprivation therapy is a mainstay of advanced prostate cancer (PCa) but the resulting low testosterone levels leave men susceptible to a multitude of adverse effects. These can include vasomotor symptoms, reduced sexual desire and ...
Testosterone Therapy in Men with Klinefelter Syndrome: Analysis of a Global Federated Research Network [0.03%]
克莱恩费尔特综合征男性患者的睾酮治疗：全球联合研究网络分析
Chase Carto,Justin Loloi,Katherine Campbell et al.
Chase Carto et al.
Introduction: The objective of this study was to determine the rates of hypogonadism and prescription of testosterone replacement therapy (TRT) in men with Klinefelter syndrome (KS). We hypothesized that men with KS are u...
Hypogonadotropic Hypogonadism in Diabesity: Pathogenic Factors and Therapeutic Implications [0.03%]
糖尿病肥胖症中的低促性腺激素性性腺功能减退：致病因素及治疗意义
Paresh Dandona,Sandeep Dhindsa,Husam Ghanim
Paresh Dandona
Abraham Morgentaler,Abdulmaged Traish,Rajat S Barua et al.
Abraham Morgentaler et al.
There has been little recognition within the medical community of the health impact of testosterone (T) deficiency (TD), also known as hypogonadism, and the substantial benefits of testosterone therapy (TTh) on health and quality of life de...
Examining Male Predominance of Severe COVID-19 Outcomes: A Systematic Review [0.03%]
男性严重新冠肺炎转归为主的系统评价
David K Twitchell,Michael B Christensen,Geoffrey Hackett et al.
David K Twitchell et al.
Although not universal, many epidemiological data sources signal that a higher proportion of males than females with confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections have adverse outcomes, such as intensive ...
Androgens and Parkinson's Disease: A Review of Human Studies and Animal Models [0.03%]
雄激素与帕金森病：人类研究和动物模型综述
Mélanie Bourque,Denis Soulet,Thérèse Di Paolo
Mélanie Bourque
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. A greater prevalence and incidence of PD are reported in men than in women, suggesting a potential contribution of sex, genetic differe...
Androgens and Their Role in Regulating Sex Differences in the Hypothalamic/Pituitary/Adrenal Axis Stress Response and Stress-Related Behaviors [0.03%]
雄激素及其在调节下丘脑/垂体/肾上腺轴应激反应和相关行为性别差异中的作用
Julietta A Sheng,Sarah M L Tan,Taben M Hale et al.
Julietta A Sheng et al.
Androgens play a pivotal role during development. These gonadal hormones and their receptors exert organizational actions that shape brain morphology in regions controlling the stress regulatory systems in a male-specific manner. Specifical...
Leire Zubiaurre-Elorza,Sebastian Cerdán,Carme Uribe et al.
Leire Zubiaurre-Elorza et al.
Transgender men (TM) experience an incongruence between the female sex assigned when they were born and their self-perceived male identity. Some TM seek for a gender affirming hormone treatment (GAHT) to induce a somatic transition from fem...
Nariko Kuwahara,Kate Nicholson,Lauren Isaacs et al.
Nariko Kuwahara et al.
Androgens are synthesized in the brain, gonads, and adrenal glands, in both sexes, exerting physiologically important effects on the structure and function of the central nervous system. These effects may contribute to the incidence and pro...
Samantha A Blankers,Liisa A M Galea
Samantha A Blankers
Adult neurogenesis in the hippocampus is modulated by steroid hormones, including androgens, in male rodents. In this review, we summarize research showing that chronic exposure to androgens, such as testosterone and dihydrotestosterone, en...