Distinct Five-Year Latent Class Trajectories and Predictors of Functional Cognitive Independence Following Traumatic Brain Injury: A TBI Model Systems Study [0.03%]
一项有关创伤性脑损伤的多态模型系统研究：功能认知独立五年内不同的潜在变化轨迹及其预测因素
Evan D Feigel,Charlotte B Luster,Chris W Lewis et al.
Evan D Feigel et al.
Early prediction of short- and long-term health outcomes remains a significant medical challenge for clinicians providing care for the traumatic brain injury (TBI) population. In the context of an acute trauma care center, accurate and earl...
Pediatric Repetitive Mild Traumatic Brain Injury Elicits T Cell-Mediated Neuroinflammation [0.03%]
重复性轻度颅脑损伤诱发小儿T细胞介导的神经炎症反应
Kirill Shumilov,Lindsay Arellano,Yongyun Shin et al.
Kirill Shumilov et al.
Pediatric repetitive mild traumatic brain injury (rmTBI) is a major public health concern with links to chronic cognitive dysfunction. Neuroinflammation represents a significant maladaptive outcome after rmTBI. Persistent innate and adaptiv...
Head Impact Exposure Across Levels of Play in American Football: A Systematic Review of Accelerometer Data [0.03%]
美式足球不同级别比赛中的头部撞击暴露：加速计数据的系统回顾
Guneet S Bindra,Christopher Lane,Jean Shanaa et al.
Guneet S Bindra et al.
With growing concern about the long-term effects of head injuries in contact sports, understanding differences in head impact exposure (HIE) across age groups is critical. Youth athletes may face heightened risks due to developmental vulner...
The Response of the Default Mode Network to Aerobic Exercise in Pediatric Concussion [0.03%]
儿童脑震荡对有氧运动的默认模式网络的反应
Bhanu Sharma,Alejandro Amador-Tejada,Eric Koelink et al.
Bhanu Sharma et al.
Submaximal aerobic exercise is an evidence-informed strategy for concussion management. However, its impact on the concussed pediatric brain remains poorly understood. A seminal adult study reported stability of default mode network (DMN) f...
Relief and Prevention of Post-Traumatic Headache Using Intranasal Delivery of Lidocaine for Youth (RAPPIDLY): A Feasibility Study [0.03%]
关于利多卡因鼻内给药缓解和预防青年创伤后头痛的可行性研究（RAPPIDLY）
Victoria Griffiths,Anne Tsampalieros,Achelle Cortel-LeBlanc et al.
Victoria Griffiths et al.
Post-traumatic headache (PTH) is prevalent following concussion, yet few evidence-based treatments exist. Intranasal lidocaine (INL) may help treat migraine; however, it has not been studied specifically for PTH in youth populations. The ob...
Peripheral and Central Administration of Soluble Glycoprotein 130 Improves Cognitive Outcomes Following Controlled Cortical Impact in Male Mice [0.03%]
外周和中枢给药可溶性糖蛋白130改善雄性小鼠控制性脑挫伤后的认知预后
Ashley L Russell,Vritika S Patel,Ian G Gober et al.
Ashley L Russell et al.
Traumatic brain injury (TBI) initiates complex immune responses, including upregulation of interleukin (IL)-6, a cytokine associated with clinical outcomes after injury. IL-6 trans-signaling, via the solubilized IL-6 receptor, drives pro-in...
Noninvasive Urinary Biomarkers for Early Diagnosis of Mild Traumatic Brain Injury [0.03%]
用于轻型颅脑损伤早期诊断的非侵入性尿液生物标志物
Akiva Cohen,Kristy B Arbogast,Young Eun Lee et al.
Akiva Cohen et al.
The lack of an easily measured biomarker hampers mild traumatic brain injury (mTBI) diagnosis and limits the ability to monitor an objective feature in patients through recovery. Due to its ease of collection and mirroring of metabolism, ur...
Can Large Language Models Answer Questions about Spinal Cord Injury? Risks, Challenges, and Opportunities-A Narrative Review [0.03%]
大型语言模型能回答关于脊髓损伤的问题吗？风险、挑战与机遇-叙述性综述
Rahul K Desai,Simran Saggu,Masha Panahi et al.
Rahul K Desai et al.
Access to high-quality health information (HI) is critical for everyone involved in the research and management of medical conditions such as spinal cord injury (SCI). Recently, the use of Large Language Models (LLMs) through AI-based chatb...
Ten-Year Latent Trajectories of Global Function and Their Associations with Social Relationship Factors: A Traumatic Brain Injury Model Systems Study [0.03%]
全球功能十年潜在轨迹及其与社会关系因素的关联：一项脑损伤治疗研究
Evan D Feigel,Michael Mastrodicasa,Charlotte B Luster et al.
Evan D Feigel et al.
The Glasgow Outcome Scale-Extended (GOS-E) measures global functional recovery status following traumatic brain injury (TBI). We aimed to identify 10-year latent GOS-E trajectories and examine their associations with social relationship fac...
Anti-CD14 Monoclonal Antibody in a Mouse Model of Severe Traumatic Brain Injury: Effects on Acute Neuroinflammation and Acute Functional Outcome [0.03%]
抗CD14单克隆抗体在重度颅脑损伤小鼠模型中的作用：对急性神经炎症和急性功能结局的影响
Emil R Peshtenski,Min Chen,Robert Sullivan et al.
Emil R Peshtenski et al.
Traumatic brain injury (TBI) is a debilitating disease that affects millions of people globally every year. Neuroinflammation following TBI is a key driver of neurodegeneration. The microglia, resident innate immune cells in the brain, are ...