Ilhan Gokhan,Thomas S Blum,Stuart G Campbell
Ilhan Gokhan
Originally developed more than 20 years ago, engineered heart tissue (EHT) has become an important tool in cardiovascular research for applications such as disease modeling and drug screening. Innovations in biomaterials, stem cell biology,...
An open computational toolbox to analyze multi- and single-unit sympathetic nerve activity in microneurography [0.03%]
开放式计算工具箱可分析微神经图中的多单位和单单位交感神经活性
Giacomo D&#x;Alesio,Lars Ingmar Stumpp,Paolo Sciarrone et al.
Giacomo D&#x;Alesio et al.
Microelectrode recordings from human peripheral and cranial nerves provide a means to study both afferent and efferent axonal signals at different levels of detail, from multi- to single-unit activity. Their analysis can lead to advancement...
Macrophages on the wrinkle: Exploring microscale interactions with substrate topography [0.03%]
皱纹上的巨噬细胞：探讨基底表面形貌与细胞的微环境相互作用
Francesca Cecilia Lauta,Luca Pellegrino,Roberto Rusconi
Francesca Cecilia Lauta
Macrophages play pivotal roles in the immune response, participating in both inflammatory and pro-healing processes. Like other cells, macrophages continually survey their microenvironment through mechanosensing, adapting their intracellula...
The impact of matrix stiffness on hepatic cell function, liver fibrosis, and hepatocellular carcinoma-Based on quantitative data [0.03%]
基质刚度对肝细胞功能、肝纤维化和肝癌的影响——基于定量数据分析
Kiyoon Min,Sathish Kumar Karuppannan,Giyoong Tae
Kiyoon Min
Over the past few decades, extensive research has explored the development of supportive scaffold materials for in vitro hepatic cell culture, to effectively mimic in vivo microenvironments. It is crucial for hepatic disease modeling, drug ...
How cytoskeletal crosstalk makes cells move: Bridging cell-free and cell studies [0.03%]
细胞骨架信号的交叉对话如何促使细胞运动？从无细胞体系到活细胞中的体液机制研究
James P Conboy,Irene Istúriz Petitjean,Anouk van der Net et al.
James P Conboy et al.
Cell migration is a fundamental process for life and is highly dependent on the dynamical and mechanical properties of the cytoskeleton. Intensive physical and biochemical crosstalk among actin, microtubules, and intermediate filaments ensu...
The magnetocardiogram [0.03%]
磁性心电图
Bradley J Roth
Bradley J Roth
The magnetic field produced by the heart's electrical activity is called the magnetocardiogram (MCG). The first 20 years of MCG research established most of the concepts, instrumentation, and computational algorithms in the field. Additiona...
M Sreepadmanabh,Ashitha B Arun,Tapomoy Bhattacharjee
M Sreepadmanabh
The natural habitat of most cells consists of complex and disordered 3D microenvironments with spatiotemporally dynamic material properties. However, prevalent methods of in vitro culture study cells under poorly biomimetic 2D confinement o...
Looking both ways: Electroactive biomaterials with bidirectional implications for dynamic cell-material crosstalk [0.03%]
双向而行：电活性生物材料在细胞-材料动态互作中的双向影响
Kathryn Kwangja Lee,Natalie Celt,Herdeline Ann M Ardoña
Kathryn Kwangja Lee
Cells exist in natural, dynamic microenvironmental niches that facilitate biological responses to external physicochemical cues such as mechanical and electrical stimuli. For excitable cells, exogenous electrical cues are of interest due to...
Deepshikha Ghosh,Anushka Biswas,Mithun Radhakrishna
Deepshikha Ghosh
Protein aggregation is a widespread phenomenon implicated in debilitating diseases like Alzheimer's, Parkinson's, and cataracts, presenting complex hurdles for the field of molecular biology. In this review, we explore the evolving realm of...
Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease [0.03%]
衔接系统生物学和组织工程：释放复杂疾病的体外三维组织模型的全部潜力
Jose L Cadavid,Nancy T Li,Alison P McGuigan
Jose L Cadavid
Rapid advances in tissue engineering have resulted in more complex and physiologically relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic development. However, the complexity provided by these models...