Single molecule DNA origami nanoarrays with controlled protein orientation [0.03%]
单分子DNA折纸纳米阵列的受控蛋白质取向
K Cervantes-Salguero,M Freeley,R E A Gwyther et al.
K Cervantes-Salguero et al.
The nanoscale organization of functional (bio)molecules on solid substrates with nanoscale spatial resolution and single-molecule control-in both position and orientation-is of great interest for the development of next-generation (bio)mole...
Eugene Cheung,Yan Xia,Marc A Caporini et al.
Eugene Cheung et al.
Spectroscopic, scattering, and imaging methods play an important role in advancing the study of pharmaceutical and biopharmaceutical therapies. The tools more familiar to scientists within industry and beyond, such as nuclear magnetic reson...
C Lorenz,S Köster
C Lorenz
Different types of biological cells respond differently to mechanical stresses, and these responses are mainly governed by the cytoskeleton. The main components of this biopolymer network are actin filaments, microtubules, and intermediate ...
Alexis Palomarez,Manisha Jha,Ximena Medina Romero et al.
Alexis Palomarez et al.
Sickle cell disease (SCD) is an inherited blood disorder caused by a single point mutation within the beta globin gene. As a result of this mutation, hemoglobin polymerizes under low oxygen conditions causing red blood cells to deform, beco...
Leveraging ultra-low interfacial tension and liquid-liquid phase separation in embedded 3D bioprinting [0.03%]
利用超低界面张力和液-液相分离进行嵌入式3D生物打印
Senthilkumar Duraivel,Vignesh Subramaniam,Steven Chisolm et al.
Senthilkumar Duraivel et al.
Many recently developed 3D bioprinting strategies operate by extruding aqueous biopolymer solutions directly into a variety of different support materials constituted from swollen, solvated, aqueous, polymer assemblies. In developing these ...
On modeling the multiscale mechanobiology of soft tissues: Challenges and progress [0.03%]
软组织多尺度力学生物学模型的挑战和进展
Yifan Guo,Mohammad R K Mofrad,Adrian Buganza Tepole
Yifan Guo
Tissues grow and remodel in response to mechanical cues, extracellular and intracellular signals experienced through various biological events, from the developing embryo to disease and aging. The macroscale response of soft tissues is typi...
Cataloguing the proteome: Current developments in single-molecule protein sequencing [0.03%]
单分子蛋白质测序的最新进展
Morgan M Brady,Anne S Meyer
Morgan M Brady
The cellular proteome is complex and dynamic, with proteins playing a critical role in cell-level biological processes that contribute to homeostasis, stimuli response, and disease pathology, among others. As such, protein analysis and char...
Katja A Salbaum,Elijah R Shelton,Friedhelm Serwane
Katja A Salbaum
With a kind of magnetism, the human retina draws the eye of neuroscientist and physicist alike. It is attractive as a self-organizing system, which forms as a part of the central nervous system via biochemical and mechanical cues. The retin...
Xin Tang,Yichun He,Jia Liu
Xin Tang
Bioelectronics for interrogation and intervention of cardiac systems is important for the study of cardiac health and disease. Interfacing cardiac systems by using conventional rigid bioelectronics is limited by the structural and mechanica...
Performance of nanoparticles for biomedical applications: The in vitro/ in vivo discrepancy [0.03%]
纳米颗粒的体外和体内生物医学性能差异及其原因分析
Simone Berger,Martin Berger,Christoph Bantz et al.
Simone Berger et al.
Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-to-date results obtained from in vitro experiments predict the in vivo performance of nanoparticles weakly or not at all. There is a need for in vitr...