How Epstein-Barr Virus Drives Multiple Sclerosis: New Mechanisms and Therapeutic Lessons [0.03%]
EB病毒如何驱动多发性硬化：新机制和治疗启示
Dan Liu,Wenhui Fan,Pengtao Jiao
Dan Liu
2-Hydroxyisobutyrylation and Phosphorylation Crosstalk Guides Metastasis Prediction and Immunotherapy in Esophageal Squamous Cell Carcinoma [0.03%]
2-羟异丁酰化和磷酸化互作引导食管鳞癌转移预测及免疫治疗
Junyi Li,Shujun Li,Xiaomei Yu et al.
Junyi Li et al.
Posttranslational modification (PTM) is pivotal in cancer progression. However, the mechanisms, biological function, and clinical significance underlying PTM crosstalk are unclear. Here, we performed systematic analyses of 2-hydroxyisobutyr...
Coronavirus M Protein Hijacks Toll-Interacting Protein (TOLLIP) to Suppress NF-κB Signaling and Promote Immune Evasion [0.03%]
冠状病毒M蛋白劫持TOLLIP抑制NF-κB信号通路以促进免疫逃逸
Yabin Zhang,Lu Kang,Yu Zhong et al.
Yabin Zhang et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) employs sophisticated strategies to subvert host innate immunity, a critical determinant of viral establishment and dissemination. Nevertheless, the immunomodulatory functions of ...
Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions [0.03%]
缺血/再灌注损伤的分子机制及干预措施
Peng An,Yi An,Mengwei Chen et al.
Peng An et al.
Ischemia-reperfusion injury (IRI) is a common pathological process underlying cardiovascular events, organ transplantation, and shock resuscitation. Its paradox is that restoration of blood flow, while essential for tissue survival, can its...
Sustained Treatment Success With Ustekinumab in Symptomatic Stricturing Crohn's Disease: A Retrospective Single-Arm Observational Cohort Study [0.03%]
ustekinumab治疗克罗恩病患者症状性狭窄的持续疗效：一项回顾性单臂观察队列研究
Jingwen Liu,Wen Hu,Shuyan Li et al.
Jingwen Liu et al.
Despite being a common complication of Crohn's disease (CD), evidence regarding the use of ustekinumab (UST) for treating symptomatic strictures in China remains limited. This study evaluated the effectiveness of UST in this population and ...
Safety and Efficacy of a Sandwich Total Neoadjuvant Therapy Strategy for Low-Risk Distal Locally Advanced Rectal Cancer: Results From the TESS Phase II Trial [0.03%]
TESS二期临床试验：低危局部晚期直肠癌夹心全新辅助治疗策略的安全性和有效性研究
Shuang Liu,GuangZhao Lv,GeYu Xu et al.
Shuang Liu et al.
This prospective phase II multicenter study evaluated a novel sandwich total neoadjuvant treatment (TNT) strategy for patients with relatively low-risk distal locally advanced rectal cancer (LARC). The regimen consisted of two cycles of cap...
Chemical-Assembled Macrophage-Engaging Glypican-3 × Signal Regulatory Protein-α (SIRP-α) Bispecific Antibody for Immunotherapy Against Liver Cancer [0.03%]
化学组装的用于肝癌免疫治疗的靶向 glypican-3 和信号调节蛋白-α（SIRP-α）双特异性抗体
Bo Tang,Wing Hei Leung,Chihao Shao et al.
Bo Tang et al.
Bispecific antibodies (BsAbs) represent a growing class of cancer immunotherapeutics, yet their wider adoption remains limited by complex recombinant production and limited manufacturing efficiency. Here, we report a chemically assembled ma...
A Phase II Trial of Perioperative Camrelizumab Plus Neoadjuvant Chemotherapy in Resectable Stage IIB-IIIB Lung Squamous Cell Carcinoma [0.03%]
特瑞普利单抗联合新辅助化疗对比单纯手术治疗II期和III期可切除肺鳞癌的多中心、随机、对照的Ⅱ期临床研究
Mingming Hu,Shuku Liu,Yi Han et al.
Mingming Hu et al.
This phase II trial investigated perioperative camrelizumab plus neoadjuvant chemotherapy for patients with stage IIB-IIIB lung squamous cell carcinoma (LUSC) and explored predictive biomarkers of treatment response. Patients received neoad...
DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia [0.03%]
缺氧条件下DDX21通过刺激RNAPII延长促进乳腺癌的发生和发展及转移
Guangqiang Li,Mingxia Deng,Leqing Zhu et al.
Guangqiang Li et al.
Hypoxia is a hallmark of solid tumors, and hypoxia-inducible factors (HIFs) are the master transcription factors that allow cancer cells to sense and cope with a hypoxic microenvironment. However, the mechanism by which the HIF-mediated tra...
Quanyou Wu,Botao Zhang,Xiaochen Zhi et al.
Quanyou Wu et al.
A comprehensive understanding of age-related changes in the human immune system is critical for deciphering the mechanisms of immunosenescence. Although transcriptomic studies have described immune alterations during aging, investigations i...