Sulforaphane Synergizes With PD-1 Blockade Through Activating CD8+ T Cells in Non-Small Cell Lung Cancer: Preclinical and Clinical Investigations [0.03%]
硫辛酸与PD-1抑制剂在非小细胞肺癌中协同作用：前期和临床研究
Jieyao Li,Jinyan Liu,Zheng Wang et al.
Jieyao Li et al.
Anti-PD-1/PD-L1 therapy has achieved promising success across several tumor types; however, its efficacy is still far from satisfactory in non-small cell lung cancer (NSCLC). Combining therapies have been attempted to synergize anti-PD-1/PD...
Non-Viral Cytokine-Inducible SH2 Containing Protein Locus-Specific Integrated Fibroblast Activation Protein Alpha-Targeting Chimeric Antigen Receptor T Cells Achieve Potent Antitumor Efficacy in Glioblastoma [0.03%]
非病毒启动子诱导的SH2结构域含有蛋白结合成纤维细胞活化蛋白α嵌合抗原受体T细胞在胶质母细胞瘤中实现强力的抗肿瘤功效
Xin Dong,Yao Sun,Yuetong Guo et al.
Xin Dong et al.
Chimeric antigen receptor T (CAR-T) cells have been used to treat patients with glioblastoma (GBM) in clinical trial settings by targeting GBM-associated antigens. However, the efficacy of these CAR-T cells remains limited mainly due to the...
Chromosome 1 Open Reading Frame 35 Drives Colorectal Cancer Progression by Enhancing Tumor-Intrinsic Proliferation and CD8+ T Cell Suppression [0.03%]
染色体1开放阅读框35通过增强肿瘤内在增殖和CD8+T细胞抑制来驱动结直肠癌进展
Shaosen Zhang,Changjiang Yang,Xunye Xu et al.
Shaosen Zhang et al.
The functional significance of Chromosome 1 open reading frame 35 (C1orf35) in colorectal cancer (CRC) remains poorly characterized. This study investigates its oncogenic role and underlying mechanisms. We report that C1orf35 is frequently ...
Mas-Related G Protein-Coupled Receptor Member D Sustains Hypertension [0.03%]
Mas相关G蛋白偶联受体D成员通过维持高血压促进心脏重塑
Kun Zhao,Dongxu Hua,Yukang Mao et al.
Kun Zhao et al.
Hypertension and its associated complications, including vascular remodeling, pose a major burden on global public health. However, the role of Mas-related G protein-coupled receptor member D (MrgD) in hypertension remains incompletely unde...
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases [0.03%]
家盒基因：分类、调控、生物学功能及与疾病的关系
Maedeh Dadzadi,Shahin Ramazi,Mona Darvazi et al.
Maedeh Dadzadi et al.
Homeobox genes constitute a large family of transcription factors that act as master regulators involved in multiple fundamental processes such as development and cell differentiation. Consequently, these transcription factors perform diver...
Enhancing Oncolytic Adenovirus Replication by Early Region 1A Protein-Mediated Degradation of E1A Binding Protein p300 [0.03%]
E1A结合蛋白p300的降解促进增效型腺病毒复制力增强机制研究
Boduan Xiao,Qingzhe Yang,Shichuan Hu et al.
Boduan Xiao et al.
Oncolytic adenovirus (OAd) therapy is one of the effective treatment strategies for solid malignant tumors, and E1A is a requirement for adenovirus replication. Thus, it is very important to study how E1A regulates adenovirus replication. T...
NDUFS1-Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation [0.03%]
NDUFS1通过促进PAX2低甲基化维持胰腺癌干细胞特性依赖于线粒体复合物I活性
Xin-Yu Fan,Wen Li,Ying Shi et al.
Xin-Yu Fan et al.
Pancreatic cancer is highly refractory and aggressive, with cancer stem cells (CSCs) being primarily responsible for its metastasis and chemoresistance. Deregulated cellular bioenergetics is a hallmark of cancer cells. However, the influenc...
Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance [0.03%]
香料及其植物化学物质的抗菌作用：克服抗生素抗性的新方法
Hettiyahandi Binodh De Silva,Yanqi Dai,Shervanthi Homer-Vanniasinkam et al.
Hettiyahandi Binodh De Silva et al.
Antibiotic resistance is a significant global health challenge that demands innovative strategies to combat resistant pathogens. Spices, known for their culinary and medicinal qualities, have emerged as promising sources of antimicrobial ag...
Yuanyuan Xue,Hao Jiang,Zhaoyun Zong et al.
Yuanyuan Xue et al.
The c-MYC oncogene, a critical driver of malignancies, is frequently associated with poor prognosis because it promotes unchecked cell proliferation and alters gene expression. Effective targeting of c-MYC using conventional therapeutic str...
Multiomics Research Strategies in Cancer: A Growing and Innovative Field [0.03%]
癌症多组学研究策略：一个日益创新的领域
Zhenhua Du,Xiaomei Liu,Zhi Lv et al.
Zhenhua Du et al.
Cancer is a highly complex and heterogeneous disease involving multiple pathophysiological events. Despite significant advances in modern medicine, the molecular mechanisms of cancer are still largely unknown. Omics methods have opened new ...