Elevated Expression of Selenoprotein Synthesis Enzyme SEPHS2 Driven by ATF4 Promotes the Resistance to Ferroptosis in Prostate Cancer [0.03%]
转录因子ATF4诱导的硒蛋白合成酶SEPHS2高表达促进前列腺癌铁死亡抵抗
Shijia Bao,Xinxing Du,Zhenkeke Tao et al.
Shijia Bao et al.
While it has been reported that antioxidant selenoproteins are crucial for anti-ferroptosis in tumors, it remains unclear whether and how biosynthetic dysregulation of selenoproteins promotes resistance to ferroptosis. By bioinformatics ana...
Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities [0.03%]
心血管疾病和癌症：在机制与治疗机会的交汇处收敛的蛋白质稳态网络
Jacob Eli García Torres,Norbert Frey,Ashraf Yusuf Rangrez
Jacob Eli García Torres
Cancer and cardiovascular diseases, the primary causes of mortality globally, are increasingly understood as biologically interconnected rather than distinct pathologies. Recent evidence indicates that protein homeostasis (proteostasis) fun...
A Chemotherapy Progression Decision Score for Treatment Selection After Initial Assessment in Pancreatic Ductal Adenocarcinoma [0.03%]
胰腺导管腺癌一线治疗后选择后续治疗方案的化疗评估评分系统
Yixin Zhang,Zhongquan Sun,Hongfan Ding et al.
Yixin Zhang et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with chemotherapy response evaluation currently relying on the Response Evaluation Criteria in Solid Tumors (RECIST). However, RECIST inadequately captures...
Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury [0.03%]
Rab8a依赖的中性粒细胞与线粒体之间的脂滴栓系丢失参与缺氧/复氧损伤
Jialing Tang,Nathan Joyce,Thomas Laval et al.
Jialing Tang et al.
Tethering of lipid droplets (LDs) to mitochondria facilitates fatty acid oxidation and is a key adaptive response that helps cardiomyocytes cope with hypoxia-reoxygenation (HR) stress. However, the molecular mechanisms regulating these inte...
Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS-CoV-2 Infection [0.03%]
恒河猴感染SARS-CoV-2后的脑区蛋白质组及磷酸化蛋白质组特征分析
Qiaochu Wang,Yanan Zhou,Tao Ding et al.
Qiaochu Wang et al.
The SARS-CoV-2 Omicron variant is more contagious than the original Alpha variant and can still cause neurological symptoms, including cognitive impairment. To gain a deeper understanding of the molecular mechanisms underlying these neurolo...
Antibody-Drug Conjugates and Peptide-Drug Conjugates: Current Understandings and Future Perspectives [0.03%]
抗体偶联药物和肽类药物偶联物：现状与未来展望
Ruxi Zheng,Shuiquan Li,Zhigang Zhang et al.
Ruxi Zheng et al.
Antibody-drug conjugates (ADCs) and peptide-drug conjugates (PDCs) are modular targeted therapeutics in which molecular recognition is coupled with controlled payload delivery. Owing to their high specificity and precision, they have been r...
Longitudinal Molecular Epidemiology and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae in the Gut of Healthy Individuals in China [0.03%]
中国健康人群肠道碳青霉烯耐药肺炎克雷伯菌的纵向分子流行病学和基因组监测研究
Zelin Yan,Yan Li,Yi Sun et al.
Zelin Yan et al.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) was identified by the World Health Organization in 2024 as a key priority bacterium for the development of novel control strategies. While most surveillance studies have focused on clinical ...
Correction to "Therapeutic Galectin-3 Apheresis Improves Sepsis Outcomes through Coordinated Neutrophil Modulation and Endothelial Barrier Preservation: A Translational Study" [0.03%]
“治疗性半乳糖凝集素-3吸附通过协调中性粒细胞调节和内皮屏障保护改善脓毒症预后：一项转化研究”的勘误通知
[This corrects the article DOI: 10.1002/mco2.70659.]. © 2026 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Asso...
Published Erratum
MedComm. 2026 Aug 5;7(8):e70853. DOI:10.1002/mco2.70853 2026
[This corrects the article DOI: 10.1002/mco2.70369.]. © 2026 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Asso...
Published Erratum
MedComm. 2026 Aug 5;7(8):e70755. DOI:10.1002/mco2.70755 2026
Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha-Fatty-Acid Amide Hydrolase 1 Signaling Pathway [0.03%]
Resmetirom通过甲状腺激素受体α-脂肪酸酰胺水酶1信号通路改善肝星状细胞纤维化
Eva Novoa,Alba Cabaleiro,Borja López-Picallo et al.
Eva Novoa et al.
Resmetirom is a liver-directed, thyroid hormone receptor β (THRβ)-selective agonist approved for treating metabolic-associated steatohepatitis (MASH). While Resmetirom hepatocyte-specific effects are well-established, its impact on other ...