Zhihao Shang,Zijiao Tian,Zhaoquan Wang et al.
Zhihao Shang et al.
Chronic pain represents a pervasive global health crisis and a leading cause of disability, yet its management remains challenged by the intricate heterogeneity of its underlying mechanisms. Transcending traditional symptom-based paradigms,...
Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies [0.03%]
肿瘤内的微生物：当前的理解和新兴的治疗策略
Haoling Zhang,Zengkan Du,Ping Lu et al.
Haoling Zhang et al.
Recent advances in high-throughput sequencing, spatial omics, and integrative multiomics analyses have established reproducibly detectable microbial communities within tumor tissues, leading to the conceptualization of tumors as complex eco...
A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1-Driven Raf-ERK Pathway Activation Promotes Cardiomyocyte Mitosis [0.03%]
一种新型丹参素B抗心肌梗死促心肌细胞增殖机制：通过PHB1驱动Raf-ERK信号通路促进心肌细胞有丝分裂作用
Ce Cao,Bo Ma,Jian Zhang et al.
Ce Cao et al.
Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Salvianolic acid B (SalB), one of the major active components of Salvia miltiorrhiza B...
Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors [0.03%]
一种耐药性抗HIV衣壳活性的含喹唑啉酮苯丙氨酸衍生物的研究发现
Xujie Zhang,Lin Sun,Laura Walsham et al.
Xujie Zhang et al.
The HIV-1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle. Using structure-based strategy, we designed and synthesized a series of phenylalanine derivatives con...
Jiaorong Qu,Wenqing Qin,Minghang Dong et al.
Jiaorong Qu et al.
Liver fibrosis is a common pathological process, leading to the development of end-stage liver diseases. It is triggered by various etiological drivers including viral hepatitis, metabolic-associated steatotic liver disease (MASLD), and cho...
Laryngeal Transplantation in Cancer Patients: Evaluation of Surgical Outcomes and Functional Recovery [0.03%]
喉移植在癌症患者中的手术效果和功能恢复评估
Zheng Jiang,Mailudan Ainiwaer,Pengwei Zhao et al.
Zheng Jiang et al.
Laryngeal transplantation offers a promising avenue for functional restoration following total laryngectomy, yet concerns regarding cancer recurrence and perioperative challenges persist. This pilot study evaluates the preliminary outcomes ...
BCR-ABL1 Drives Transcriptional Reprogramming of Chronic Myeloid Leukemia Cells for Immune Evasion Through C/EBPβ [0.03%]
BCR-ABL1通过C/EBPβ驱动慢性髓系白血病细胞转录重构以逃避免疫攻击
Xiaocui Lu,Hui Fang,Yuan Liu et al.
Xiaocui Lu et al.
Emerging immunotherapy holds promise to achieve treatment-free remission (TFR) for chronic myeloid leukemia (CML) patients, the development of which depends on full understanding of mechanisms driving immune evasion. Our current investigati...
Optimal Adjuvant Therapy Selection for Chinese BRAF V600-Mutant Stage III Melanoma: A Multicenter Efficacy Comparison of Targeted Agents, Immunotherapy, and Combinatorial Strategies [0.03%]
中国BRAF突变型三期黑色素瘤最佳辅助治疗选择：靶向药物、免疫疗法及联合策略的多中心疗效比较研究
Rongcheng Zhang,Yao Liang,Jingjing Li et al.
Rongcheng Zhang et al.
While adjuvant immunotherapy and BRAF/MEK inhibitors improve the outcomes for BRAF V600-mutant stage III melanoma, comparisons of long-term survival and safety of these therapeutic modalities are currently lacking in Chinese patients. We re...
High-Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor [0.03%]
高通量筛选显示CeeNU作为新的NLRP3炎性小体抑制剂的作用
Sen-Lin Ji,Peipei Chen,Huaiping Tang et al.
Sen-Lin Ji et al.
Pyroptosis is a special form of cell death that often occurs during excessive inflammation and injury, leading to tissue damage, disease progression, and other related issues. The Nod-like receptor family pyrin domain-containing 3 (NLRP3) i...
Performance and Effectiveness of DeepSeek in Assisting Diagnosis of Acutely and Critically Ill Patients: A Single-Center Retrospective Study [0.03%]
深度学习辅助急性重症患者诊治的效能研究：单中心回顾性研究
Teng Huang,Jinzhao Zhang,Junpeng Tang et al.
Teng Huang et al.