The Clinical and Metabolic Profiles in Menstrual Changes Among Reproductive-Aged Women Post-COVID-19 [0.03%]
新冠后生育年龄妇女月经变化的临床及代谢特征 profiling
Wei Wang,Manfei Si,Xinyu Qi et al.
Wei Wang et al.
Menstruation is a key indicator of female reproductive health, yet clinical features and underlying mechanisms associated with menstrual changes following the coronavirus disease 2019 (COVID-19) infection remain unclear. Here, we recruited ...
Superior Diagnostic Efficacy of N-Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients [0.03%]
N末端三型胶原胜肽与高尔基体蛋白73检测慢性乙型肝炎患者肝纤维化的诊断价值较高
Qianqian Chen,Ming-Hua Zheng,Li Zhu et al.
Qianqian Chen et al.
Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO-C3, GP73, and their combination for the presenc...
Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases [0.03%]
线粒体移植：治疗疾病的新方法
Xinglu Miao,Pei Jiang,Zhaoping Wang et al.
Xinglu Miao et al.
Advances in mitochondrial biology have led to the development of mitochondrial transplantation as a novel and promising therapeutic strategy. This review provides a comprehensive analysis of the multifaceted roles of mitochondria in health ...
Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects [0.03%]
白藜芦醇的分子机制、健康效益及其潜在不良反应
Zhuo-Qun Ren,Sheng-Yuan Zheng,Zhengcheng Sun et al.
Zhuo-Qun Ren et al.
Resveratrol (RES), a naturally occurring polyphenolic compound, has garnered significant attention due to its diverse biological activities, which include anti-inflammatory, antioxidant, and antiaging properties. This review synthesizes cur...
Jingru Tian,Hang Zhou,Wei Li et al.
Jingru Tian et al.
Systemic lupus erythematosus (SLE) is a multifaceted dautoimmune disease driven by complex interactions among genetic, environmental, and sex-related factors. Central to its pathogenesis are type I interferons (IFN-I) and autoantibodies tha...
Glycoprotein Ibα-Dependent Platelet Activation is Essential for Tumor Cell-Platelet Interaction and Experimental Metastasis [0.03%]
甘露聚糖结合凝集素依赖的血小板活化对肿瘤细胞-血小板相互作用和实验性转移的作用essential for tumor cell-platelet interaction and experimental metastasis
Kangxi Zhou,Qing Li,Yue Xia et al.
Kangxi Zhou et al.
Metastasis is the main cause of cancer-related deaths and the biggest challenge in improving cancer prognosis. Platelet-tumor cell aggregates are a prerequisite for hematogenous metastasis. However, the internal relation and molecular mecha...
Deep Learning in Digital Breast Tomosynthesis: Current Status, Challenges, and Future Trends [0.03%]
数字乳腺断层合成中的深度学习：现状、挑战与未来趋势
Ruoyun Wang,Fanxuan Chen,Haoman Chen et al.
Ruoyun Wang et al.
The high-resolution three-dimensional (3D) images generated with digital breast tomosynthesis (DBT) in the screening of breast cancer offer new possibilities for early disease diagnosis. Early detection is especially important as the incide...
Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression [0.03%]
长非编码RNA IL6-AS1通过外泌体促进慢性阻塞性肺病进程中肺巨噬细胞的炎症效应（S100A9/TLR4通路）
Erkang Yi,Xiaoyu Wang,Yu Liu et al.
Erkang Yi et al.
This study investigates the role of interleukin 6 antisense RNA 1 (IL6-AS1), a highly expressed long noncoding RNA (lncRNA), in chronic obstructive pulmonary disease (COPD). An adeno-associated virus (AAV) was used to induce the expression ...
The Nasal-Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases [0.03%]
鼻脑递送途径：机制与中枢神经系统疾病应用
Yi Qiu,Shiyuan Huang,Li Peng et al.
Yi Qiu et al.
The blood-brain barrier (BBB) is a highly selective and protective barrier that restricts the entry of most therapeutic agents into the central nervous system (CNS), posing a significant challenge for the treatment of CNS diseases. The nose...
Discovery and Validation of Novel Biomarkers for Colorectal Neoplasia Detection via Plasma Metabolomics [0.03%]
基于血浆代谢组学的结直肠系肿瘤新生物标志物的发现和验证
Jianv Huang,Le Wang,Xiang Zhang et al.
Jianv Huang et al.
Metabolic disturbance plays a critical role in the initiation of colorectal cancer (CRC), yet the identification of metabolites that are useful for early detection of CRC and its precursor lesions remains elusive. We conducted an untargeted...