The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity [0.03%]
调节性B细胞在感染、癌症和免疫中的双重作用
Anni Feng,Qilong Li,Ning Jiang et al.
Anni Feng et al.
Regulatory B cells (Bregs) are a functionally defined yet phenotypically heterogeneous subset of lymphocytes that are essential for maintaining immune homeostasis. Their canonical function is regulated through the secretion of interleukin-1...
Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein [0.03%]
Mpox病毒A35R蛋白高度保护性中和抗体的发现及结构特征分析
Shimeng Bai,Shuo Song,Xin Wang et al.
Shimeng Bai et al.
The recent resurgence of the mpox virus (MPXV) has raised global health concerns due to its potential to cause severe illness in vulnerable populations. Targeting the extracellular enveloped virus (EEV) protein A35R is a promising strategy ...
Generative Artificial Intelligence and Large Language Models in Clinical Oncology [0.03%]
临床肿瘤学中的生成式人工智能和大型语言模型
Yunfang Yu,Zhenhui Zhao,Zehua Wang et al.
Yunfang Yu et al.
Cancer remains a major global health challenge, and the increasing availability of multimodal biomedical data has created unprecedented opportunities for precision oncology. Recent advances in generative artificial intelligence (AI), partic...
EGFR-Targeting IgG1 Antibody Enhances NK Cell-Mediated Tumor Killing in KRAS-Mutant Pancreatic Cancer [0.03%]
针对EGFR的IgG1抗体通过增强NK细胞介导的杀伤作用抑制KRAS突变型胰腺癌
Ruoxi Xiao,Xiaoxiao Li,Ping Li et al.
Ruoxi Xiao et al.
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) exhibits intrinsic resistance to epidermal growth factor receptor (EGFR)-targeted therapies owing to constitutive downstream pathway activation. Nevertheless, IgG1 antibodies may retain th...
RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment [0.03%]
肿瘤微环境中RNA修饰在癌症治疗中的新作用维度
Qiwen Li,Yating Sun,Shuibin Lin et al.
Qiwen Li et al.
RNA modifications are pivotal posttranscriptional gene expression regulators with profound functions in both physiological and pathological states, particularly during cancer initiation and progression. Within the complex tumor microenviron...
Dynamics of Circulating Tumor DNA (ctDNA) Predict Treatment Efficacy and Prognosis in Patients With Advanced Pancreatic Cancer: A Prospective Large-Cohort Study [0.03%]
前瞻性大规模队列研究评估循环肿瘤DNA（ctDNA）的动态变化预测晚期胰腺癌患者预后的效能
Tingting You,Hui Tang,Mingming Yuan et al.
Tingting You et al.
Current methods for assessing treatment response and prognosis in pancreatic ductal adenocarcinoma (PDAC) have intrinsic limitations, necessitating novel biomarkers. This prospective cohort study evaluated whether early dynamic changes in c...
Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives [0.03%]
肿瘤内微生物群：现状与未来展望
Jiawei Chen,Yupan Bai,Lu Shen et al.
Jiawei Chen et al.
Intratumoral bacteria are increasingly recognized as integral and dynamic components of the tumor microenvironment (TME), with profound implications for tumor initiation, progression, metastasis, immune remodeling, and therapeutic response....
Sorafenib Restores Pentose Phosphate Pathway-Related Redox Homeostasis via the c-Raf/HSP90/G6PD Axis in Hepatic Ischemia-Reperfusion Injury [0.03%]
索拉非尼通过c-Raf/HSP90/G6PD轴恢复戊糖磷酸途径相关氧化还原稳态在肝缺血再灌注损伤中的作用
Fengqiang Gao,Libin Dong,Yawen Tan et al.
Fengqiang Gao et al.
Hepatic ischemia reperfusion injury (IRI) is a frequent complication of liver surgery and is strongly associated with poorer recipient survival. Sorafenib, a multi-kinase inhibitor, has been implicated in hepatic metabolic and redox regulat...
Novel Phenotypes of Acute Respiratory Failure and Differential Response to Awake Prone Positioning: A Multi-Cohort Study [0.03%]
急性呼吸衰竭的新表型及清醒俯卧位治疗的不同反应：多队列研究
Nan Shi,Ruiqiang Zheng,Xufeng Chen et al.
Nan Shi et al.
The heterogeneity of acute respiratory failure (ARF) in non-intubated patients remains poorly defined. This study aimed to identify novel phenotypes in non-intubated ARF patients and evaluate their prognostic and predictive ability. We anal...
Yuanze Luo,Assam El-Osta
Yuanze Luo