Yingqi Kuang,Fangfang Zhou
Yingqi Kuang
Development and Validation of a Pathomics Model for Prognosis Prediction in Neoadjuvant Therapy-Treated Breast Cancer: A Retrospective, Multicenter Study [0.03%]
新辅助治疗乳腺癌预后预测的病理组学模型的开发和验证：一项回顾性、多中心研究
Yani Wei,Wei Lou,Zongbo Han et al.
Yani Wei et al.
Accurate outcome prediction is essential for personalized therapy in patients with breast cancer receiving neoadjuvant therapy (NAT). In this study, we developed and validated a multimodal artificial intelligence model, the ClinicHistomics ...
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy [0.03%]
肿瘤异质性和癌细胞可塑性：分子机制与精准治疗
Hanwen Hu,Zhixing Hao,Lili Li et al.
Hanwen Hu et al.
Tumor heterogeneity creates selective pressures and ecological niches that enable cancer cell plasticity; conversely, plasticity continuously generates and reshapes heterogeneity. Together, these processes drive tumor progression, therapeut...
Osimertinib Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Mechanisms and Therapeutic Strategies [0.03%]
表皮生长因子受体突变非小细胞肺癌奥希替尼耐药机制及治疗策略
Junfeng Guo,Qiuyuan Wen,Songqing Fan
Junfeng Guo
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, with epidermal growth factor receptor (EGFR) mutations being one of the most common actionable genetic alterations. Osimertinib, a third-generation EG...
Jian Liu,Xinyan Wu,Ting Yin et al.
Jian Liu et al.
Epilepsy is a common neurological disorder with a substantial global burden. Despite major advances in diagnosis and therapy, nearly one-third of patients remain resistant to antiseizure medications, highlighting persistent gaps in understa...
Metabolic Dysfunction-Associated Fatty Liver Disease: From Pathogenesis to Treatment [0.03%]
代谢功能紊乱相关性脂肪肝病：从发病机制到治疗对策
Zhifu Cui,Xiaxia Du,Felix Kwame Amevor et al.
Zhifu Cui et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide and represents a major hepatic manifestation of systemic metabolic dysfunction. The disease is closely linked to obes...
Dexmedetomidine Rapidly Relieves Stress-Induced Hyperalgesia via Presynaptic α 2-Adrenergic Inhibition at Orbitofrontal-Insular Glutamatergic Synapses [0.03%]
右美托咪啶通过海马区谷氨酸能突触上 presynapticα2-肾上腺素能抑制快速缓解应激诱导的痛觉过敏
Hui Rong,Yang-Xun Zhang,Huijie Zhu et al.
Hui Rong et al.
Dexmedetomidine (Dex), an α2-adrenergic receptor (α2-AR) agonist, is widely used for its antihyperalgesic effects in perioperative pain management, yet its underlying mechanisms remain largely undefined. Here, we identify a rapid, circuit...
Qin Ru,Dongliang Yuan,Shide Jiang et al.
Qin Ru et al.
Osteoarthritis (OA) is a highly prevalent, heterogeneous whole-joint disorder that represents a leading cause of chronic pain, physical disability, and socioeconomic burden globally. It has emerged as a major public health challenge affecti...
Multiomics Identification and Validation of an Integrin-Extracellular Matrix Network Driving Respiratory Syncytial Virus-Induced Lung Injury and Repair [0.03%]
整合素-细胞外基质网络驱动呼吸道合胞病毒诱导的肺损伤和修复的多组学识别和验证
Lili Zhou,Hua Guo,Xiaofeng Yu et al.
Lili Zhou et al.
Respiratory syncytial virus (RSV) is a major cause of severe lung injury, particularly in infants. Most previous studies have relied on single-omics or single-model systems, limiting a comprehensive understanding of the dynamic and coordina...
A Low Serum Calcium-to-Potassium Ratio Predicts Postpartum Venous Thromboembolism Risk: Mediation by Hemoglobin and D-Dimer in a Multicenter Cohort [0.03%]
低血钙与钾比值预测产后静脉血栓栓塞风险：一项多中心队列研究中的中介作用-由血红蛋白和D-二聚体介导
Qian Li,Guofu Zhang,Xiating Li et al.
Qian Li et al.
Postpartum venous thromboembolism (VTE) is a serious complication, and electrolytes may play a role in coagulation homeostasis, but their associations with postpartum VTE remain unclear. A total of 25,792 pregnant women from Chinese multice...