Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage-Dependent Anion Channel 1-Mediated Mitochondrial Dysfunction [0.03%]
包含65缺陷的三联体基序通过减轻电压依赖性阴离子通道1介导的线粒体功能障碍对急性肾脏损伤具有保护作用
Tao Chen,Yang Zhang,Liting Ding et al.
Tao Chen et al.
Acute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious the...
Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets [0.03%]
组织损伤与修复中的中性粒细胞：分子机制和治疗靶点
Luying Yang,Fan Shi,Feng Cao et al.
Luying Yang et al.
Tissue repair represents a highly intricate and ordered dynamic process, critically reliant on the orchestration of immune cells. Among these, neutrophils, the most abundant leukocytes in the body, emerge as the initial immune responders at...
Tianyou Ma,Tingrui Zhang,Fengze Miao et al.
Tianyou Ma et al.
Alopecia areata (AA) is a complex, chronic inflammatory skin disorder characterized by unpredictable, nonscarring hair loss, affecting millions worldwide. Its pathogenesis remains poorly understood, driven by intricate interactions among im...
Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan-Sarbecoviruses [0.03%]
广谱高效针对全谱沙贝科病毒的新型三特异性中和抗体
Rui Qiao,Yuanchen Liu,Qiyu Mao et al.
Rui Qiao et al.
The ongoing emergence of new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the urgent need for developing antivirals targeting both SARS-CoV-2 variants and related sarbecoviruses. To this end, we d...
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy [0.03%]
肠道微生物群失调：发病机理、疾病、预防和治疗
Yao Shen,Nairui Fan,Shu-Xia Ma et al.
Yao Shen et al.
Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregu...
Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy [0.03%]
海马区星形胶质细胞ATP/腺苷释放失调导致认知和情感障碍：分子机制、诊断与治疗
Peter Illes,Patrizia Rubini,Henning Ulrich et al.
Peter Illes et al.
The gliotransmitter adenosine 5'-triphosphate (ATP) and its enzymatic degradation product adenosine play a major role in orchestrating in the hippocampus cognitive and affective functions via P2 purinoceptors (P2X, P2Y) and P1 adenosine rec...
Modeling Stromal Cells Inside the Tumor Microenvironment of Ovarian Cancer: In Vitro Generation of Cancer-Associated Fibroblast-Like Cells and Their Impact in a 3D Model [0.03%]
卵巢癌肿瘤微环境中间质细胞的建模及体外成纤维母细胞向癌相关成纤维细胞转化及其对三维培养模型的影响
Jacopo Romoli,Paola Chiodelli,Patrizia Bonassi Signoroni et al.
Jacopo Romoli et al.
The tumor microenvironment (TME) is the combination of cells and factors that promotes tumor progression, and cancer-associated fibroblasts (CAFs) are a key component within TME. CAF originates from various stromal cells and is activated by...
Single-Cell Transcriptomics Revealed E-Cigarettes-Induced Vascular Remodeling by Enhancing Tcf21 Expression [0.03%]
单细胞测序揭示了通过增强Tcf21表达电子烟引起血管重塑
Ruiyang Ding,Xiaoke Ren,Qinglin Sun et al.
Ruiyang Ding et al.
GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases [0.03%]
GABAB受体：结构、生物学功能及疾病治疗
Weijie Xie,Yuan Li,Xinyue Wang et al.
Weijie Xie et al.
Gamma-aminobutyric acid (GABA) B receptors (GABABRs) that acts slowly and maintains the inhibitory tone are versatile regulators in the complex nervous behaviors and their involvement in various neuropsychiatric disorders, such as anxiety, ...
Integrative Multiomics Profiling of Mouse Hippocampus Reveals Transcriptional Upregulation of Interferon-Stimulated Genes Through PU.1 Regulator in Microglial Activation Induced by Chronic Cerebral Hypoperfusion [0.03%]
整合多组学分析揭示了慢性脑低灌注小鼠海马体的小胶质活化通过PU.1调节诱导干扰素刺激基因转录上调
Zengyu Zhang,Dewen Ru,Zhuohang Liu et al.
Zengyu Zhang et al.
Chronic cerebral hypoperfusion (CCH) is a significant factor that accelerates cognitive deterioration, yet the mechanisms of hippocampal microglial activation in this context remain unclear. Using an integrative multiomics approach, we inve...