A Synergistic Dual-Antibody Cocktail Targeting α-Toxin Protects Against Invasive Staphylococcus aureus Infection by Neutralizing Virulence and Enhancing Host Defense [0.03%]
一种协同作用的双抗体鸡尾酒可靶向α-毒素通过中和毒性并增强宿主防御来抵御侵袭性金黄色葡萄球菌感染
Liqun Zhao,Zhen Song,Hongyin Fan et al.
Liqun Zhao et al.
Staphylococcus aureus is a leading cause of severe invasive infections and is associated with high mortality. The pore-forming α-toxin (Hla) is a key virulence determinant that drives disease severity. We identified two high-affinity anti-...
Nicotinamide N-Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma [0.03%]
烟酰胺N-甲基转移酶通过H3K9me3重编程表观遗传学活化纤连蛋白1在透明细胞肾细胞癌中的作用
Lingling Wang,Yueyang Wang,Qizheng Han et al.
Lingling Wang et al.
Clear cell renal cell carcinoma (ccRCC) is among the most prevalent malignancies of the urinary system. Patients with advanced ccRCC have poor clinical outcomes. This study aimed to investigate the role of nicotinamide N-methyltransferase (...
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers [0.03%]
细胞衰老与衰老：机制、疾病交汇和治疗前沿
Guowei Cai,Jia Ren,Li Wang et al.
Guowei Cai et al.
Cellular senescence, a stress-induced, irreversible cell cycle arrest coupled with a proinflammatory secretory phenotype, has emerged as both a central driver of aging and a tractable therapeutic target. Although acute senescence contribute...
Chemoimmunotherapy Combined With Antiangiogenic Therapy in Advanced Triple-Negative Breast Cancer: Real-World Outcomes From a Retrospective Cohort Study [0.03%]
抗血管生成联合化疗免疫治疗转移性三阴乳腺癌的疗效分析：一项回顾性队列研究的结果
Yudong Li,Jinna Lin,Mengdi Zhu et al.
Yudong Li et al.
Triple-negative breast cancer (TNBC) has a poor prognosis and limited treatment options. Although programmed death protein 1 (PD-1) inhibitor-based chemotherapy and its combination with antiangiogenic agents are increasingly used clinically...
Acylglycerol Kinase Inhibition Restores Mitophagy and Alleviates Alzheimer's Disease Pathology [0.03%]
酰基甘油激酶抑制恢复线粒体自噬并缓解阿尔茨海默病病理变化
Wensheng Li,Xuan Yu,Cuiping Guo et al.
Wensheng Li et al.
Mitophagy is a conserved cellular process that removes dysfunctional or excess mitochondria. Increasing evidence suggests that impaired mitophagy plays a crucial role in AD development. Promoting mitophagy has been shown to be protective in...
Concurrent Chemoradiotherapy Plus Immunotherapy Versus Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer: A Randomized, Single-Center, Phase II Trial of Early Tumor Regression and Pro-Inflammatory Tumor Microenvironment Remodeling [0.03%]
同步放化疗联合免疫治疗与单纯同步放化疗治疗局部晚期宫颈癌：一项关于早期肿瘤消退和促炎症肿瘤微环境重塑的随机、单中心II期临床试验
Yuhan Sheng,Yu Chang,Yao Jiang et al.
Yuhan Sheng et al.
Concurrent chemoradiotherapy (CCRT) followed by intrauterine brachytherapy is the standard treatment for locally advanced cervical cancer (LACC), yet its efficacy is frequently constrained by an immunosuppressive tumor microenvironment (TME...
Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management [0.03%]
子宫内膜异位症的流行病学、危险因素、分子机制、诊断和治疗
Kun Wang,Dongyun He,Yang Wang et al.
Kun Wang et al.
Endometriosis is a chronic estrogen-dependent gynecological disorder characterized by the ectopic growth of endometrial-like tissue outside the uterine cavity, affecting approximately 10% of women of reproductive age worldwide. It is a lead...
Integrated Genomic, Transcriptomic, and Circulating Biomarkers Predict Benefit to Immune Checkpoint Inhibitor Plus Chemotherapy in Advanced Non-Small Cell Lung Cancer [0.03%]
整合基因组、转录组和循环生物标志物可预测晚期非小细胞肺癌免疫检查点抑制剂联合化疗的疗效
Lailing Li,Dandan Han,Xiaoliang Zhang et al.
Lailing Li et al.
Combined immune checkpoint inhibitor (ICI) and chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) without targetable driver mutations. However, reliable biomarkers predictive of clinical benefi...
Current Landscape and Future Perspectives of Diabetic Retinopathy Therapy: Pharmacological Targets, Precision Laser Technology, and Clinical Evidence [0.03%]
糖尿病视网膜病变治疗的现状与展望：药物靶点、精准激光技术和临床证据
Xinying Hu,Zhe Cha,Ao Lu et al.
Xinying Hu et al.
Diabetic retinopathy (DR), a major cause of blindness worldwide, poses a substantial and escalating burden on public health. The limitations of current therapeutic modalities highlight the pressing need for continued innovation in therapeut...
The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications [0.03%]
焦亡的多面体作用：分子机制、与其他细胞死亡途径的相互作用及治疗意义
Diego Liviu Boaru,Patricia De Castro-Martinez,Cielo Garcia-Montero et al.
Diego Liviu Boaru et al.
Pyroptosis is a tightly regulated, proinflammatory form of programmed cell death defined by gasdermin-mediated membrane pore formation and cytokine release. By coupling cell death to innate immune activation, pyroptosis occupies a unique po...