Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management [0.03%]
脑梗死：流行病学、分类、机制、诊断和治疗管理
Meibiao Zhang,Jianxun Hou,Jia Kuang et al.
Meibiao Zhang et al.
Cerebral infarction, the pathological basis of ischemic stroke, remains a leading cause of mortality and long-term disability worldwide. Its clinical heterogeneity reflects the complex interplay among vascular pathology, metabolic failure, ...
Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy [0.03%]
癌症神经科学：治疗的新理念和策略
Ting Wang,Zikai Dong,Yongfei Wang et al.
Ting Wang et al.
Cancer neuroscience has emerged as a paradigm-shifting discipline that reveals the active role of the nervous system in tumor development and progression. This review synthesizes current understanding of how bidirectional interactions betwe...
Blood-Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems [0.03%]
血脑屏障：结构、功能、疾病及药物递送系统
Yanan He,Mengyao Qu,Lu Yu et al.
Yanan He et al.
The blood-brain barrier (BBB) is a highly selective and dynamic neurovascular interface essential for maintaining central nervous system homeostasis. This specialized barrier comprises brain microvascular endothelial cells interconnected by...
Dynamic T-Cell Reprogramming Modulates the Treatment Outcome of Neoadjuvant Immunochemotherapy in Non-Small-Cell Lung Cancer [0.03%]
动态T细胞重编程调节非小细胞肺癌新辅助免疫化疗的治疗效果
Rui Jin,Anhao Tian,Weina Lu et al.
Rui Jin et al.
Although immunochemotherapy sheds light on neoadjuvant strategies, about two-thirds of patients still respond poorly to perioperative chemoimmunotherapy. Hence, it is crucial to investigate the underlying response mechanism to improve the p...
Yujie Xu,Xueting Liu,Yidi Wang et al.
Yujie Xu et al.
Early maturation poses a considerable health challenge worldwide. We aim to quantify the global disease burden attributable to early maturation in 2021. We calculated sex-specific and region-specific population attributable fractions (PAFs)...
Isocitrate Dehydrogenase-Mutant Astrocytomas: Risk Stratification and Therapeutic Advance [0.03%]
异柠檬酸脱氢酶突变型 astrocytoma 的风险分层和治疗进展
Shepeng Wei,Xuxu Xu,Jing Bao et al.
Shepeng Wei et al.
Isocitrate dehydrogenase (IDH)-mutant astrocytomas are recognized as a single molecular entity spanning CNS WHO Grades 2-4, and clinical behavior is shaped by early lineage-defining alterations (IDH1/2, ATRX, TP53) and by later events linke...
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives [0.03%]
胶质淋巴系统与脑膜淋巴管：现状和未来展望
Hangzhe Sun,Haonan Fan,Yuhang Zhou et al.
Hangzhe Sun et al.
The central nervous system (CNS) maintains homeostasis and immune surveillance through a recently defined brain-wide clearance network: the glymphatic-lymphatic axis. This system couples the intramural glymphatic pathway, responsible for co...
Heterogeneity of Treatment Effect for Intra-Aortic Balloon Pump Use Across Lactate Trajectories in Cardiogenic Shock Patients Supported by VA-ECMO: An Analysis of the Chinese Extracorporeal Life Support Registry [0.03%]
基于中国体外生命支持注册库的VA-ECMO支持的心源性休克患者不同乳酸轨迹下使用IABP的治疗效果异质性分析
Xiang-Jie Duan,Bo Wang,Cheng-Long Li et al.
Xiang-Jie Duan et al.
This study aimed to investigate the heterogeneity of treatment effect for intra-aortic balloon pump (IABP) across various lactate trajectories in patients with acute myocardial infarction-related cardiogenic shock (AMICS) supported by veno-...
Metabolic Alterations in Macrophage Subtypes Propel Immune and Stromal Remodeling in Neurofibroma's Malignant Progression [0.03%]
神经纤维瘤恶性演变进程中巨噬细胞亚型的代谢改变促进免疫和基质重塑
Ling-Ling Ge,Yue-Hua Li,Xuan Yu et al.
Ling-Ling Ge et al.
Neurofibromatosis type 1 (NF1) is characterized by the development of benign plexiform neurofibromas (PNFs). In 10%-15% of patients, these tumors undergo malignant transformation into aggressive malignant peripheral nerve sheath tumors (MPN...
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment [0.03%]
慢性疼痛的机制和风险至诊断及治疗研究进展
Xiaofeng Dai,Chongxiang Wang,Ping Jiang et al.
Xiaofeng Dai et al.
Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic, each with distinct biopsychosocial mechanisms. Chronic pain was historically viewed as a mo...