Deep Learning Predicts Imminent Tumor Progression in Advanced Pancreatic Adenocarcinoma Using Serial CT Scans During Chemotherapy [0.03%]
基于化疗期间连续CT扫描的深度学习预测晚期胰腺导管腺癌即将发生进展
Jun Cheng,Yize Mao,Shuxiang Huang et al.
Jun Cheng et al.
Advanced pancreatic ductal adenocarcinoma (PDAC) often progresses rapidly during chemotherapy despite initial assessments of stable disease or partial response by Response Evaluation Criteria in Solid Tumors (RECIST 1.1), underscoring the l...
Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial [0.03%]
口服亚精胺补充剂可在放射治疗后保持下颌下腺功能：机制见解及II期随机临床试验中的应用
Yu Min,Kun Gao,Yingtong Liu et al.
Yu Min et al.
Radiotherapy for head and neck cancer commonly induces salivary gland dysfunction, resulting in xerostomia that substantially impairs quality of life after treatment. To identify protective strategies, we established the irradiation-induced...
The Expression Patterns of Antibody-Drug Conjugate-Related Markers in Urothelial Carcinoma With Histological Variants [0.03%]
不同组织学亚型膀胱尿路上皮癌抗体药物偶联物相关标记物表达模式分布差异研究
Xingliang Tan,Xinpei Deng,KunYang Wang et al.
Xingliang Tan et al.
Intracranial Efficacy of Crizotinib and Postprogression Therapeutic Strategies in Advanced c-ros Oncogene 1 (ROS1)-Positive Non-Small Cell Lung Cancer (NSCLC), a Multicenter Real-World Study [0.03%]
克唑替尼颅内疗效及 ROS1阳性晚期非小细胞肺癌（NSCLC）进展后治疗策略的多中心真实世界研究
Zihua Zou,Xiaobin Zheng,Panwen Tian et al.
Zihua Zou et al.
Intracranial efficacy of crizotinib and optimal postprogression therapies in c-ros oncogene 1 (ROS1)-positive non-small cell lung cancer(NSCLC) remain under-explored. We performed a multicenter real-world study across 17 Chinese hospitals (...
Jonatan Kaszubski,Agata Wawrzyniak,Maciej Gagat et al.
Jonatan Kaszubski et al.
Atherosclerosis is a multifactor condition and driving force behind many cardiovascular diseases. Moreover, it remains a leading cause of mortality worldwide. The current therapies, including statins and fibrates, focus mainly on lipid lowe...
Yang Jin,Yanfeng Wu,Jianhua Luo
Yang Jin
De novo protein design enables the creation of proteins with entirely novel structures and biological functions from scratch, offering a promising new paradigm for cancer immunotherapy. Emerging methodologies are integrating principles of r...
Markers Predicting Cure With Combinatorial Treatment in a Mouse Model of Latent Autoimmune Diabetes in Adults [0.03%]
预测成人隐匿性自身免疫糖尿病综合治疗治愈效果的标志物：小鼠模型研究
Wisal Sawaed,Ahmad Dallasheh,Sivan Eliyahu et al.
Wisal Sawaed et al.
Diabetes encompasses a range of diseases characterized by chronic hyperglycemia and serious health complications. However, predicting therapeutic response in latent autoimmune diabetes in adults (LADA) remains a major challenge, limiting th...
Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives [0.03%]
用于治疗性基因组编辑的递送系统：挑战、创新和未来展望
Meijia Yang,Yiqiong Song,Ziyang Wang et al.
Meijia Yang et al.
Therapeutic genome editing has advanced rapidly with the development of diverse programmable nucleases, from zinc-finger nucleases and transcription activator-like effector nucleases to clustered regularly interspaced short palindromic repe...
Yu-Han Ai,Ting-Ting Xu,Sen Lin et al.
Yu-Han Ai et al.
CD8+ tissue-resident memory T (TRM) cells play a pivotal role in local immune regulation. These noncirculating T cells are uniquely positioned to orchestrate rapid site-specific immune responses, making them central to understanding tissue-...
Preoperative Albumin Infusion Reduced Pulmonary Complications in Elderly Patients With Hypoalbuminemia Undergoing Cardiac Surgery: A Single-Center, Randomized, Double-Blind, Controlled Pilot Trial [0.03%]
术前补充白蛋白可减少低白蛋白老年患者心脏手术后肺部并发症：一项单中心随机双盲对照试验
Jie Liu,Shiqiang Chen,Yunxiao Bai et al.
Jie Liu et al.
Hypoalbuminemia is a recognized risk factor for postoperative pulmonary complications (PPCs), but whether preoperative albumin infusion improves pulmonary outcomes after cardiac surgery remains unclear. In this single-center, randomized, do...