Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration [0.03%]
通过tRNA片段重新编程胶质细胞代谢可保存视网膜神经退行性疾病中的视力
Yuke Ji,Sha Liu,Ying Zhang et al.
Yuke Ji et al.
Retinal neurodegeneration leads to progressive and irreversible vision loss driven by retinal ganglion cell (RGC) death, yet effective neuroprotective therapies remain lacking. Recent studies suggest that small non-coding RNAs play key role...
Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment [0.03%]
冠状微血管功能不全：流行病学、病理生理学、诊断和治疗
Zhao Ge,MaoZe Zhang,Xujin Ning et al.
Zhao Ge et al.
Coronary microvascular dysfunction (CMD) is a key contributor to myocardial ischemia and cardiovascular diseases. It is characterized by abnormalities of the coronary microvasculature, leading to impaired myocardial perfusion. Although CMD ...
Genetically Engineered Probiotic Nanoplatform for Ultrasound-Enhanced Colorectal Cancer Therapy via Targeted Delivery, Immune Modulation, and Anti-Angiogenesis [0.03%]
基因工程益生菌纳米平台通过靶向递送、免疫调节和抗血管生成进行超声增强型结直肠癌治疗
Jie Long,Tongrui Shang,Xuezhong Mo et al.
Jie Long et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely due to limitations in early diagnosis and effective treatment. To address these challenges, we developed a multifunctional probiotic nanoplatform...
Targeting the NAT1-ENO1-Lactate Axis Destabilizes PD-L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer [0.03%]
靶向NAT1-ENO1-乳酸轴降解PD-L1以重振结直肠癌的抗肿瘤免疫
Yi-Xuan Liu,Wen-Xin Wu,Yang Zang et al.
Yi-Xuan Liu et al.
Metabolic dysregulation is a hallmark of tumorigenesis and profoundly impacts immune surveillance; however, the underlying mechanisms and targeted treatments remain limited in colorectal cancer (CRC). Here, we utilize public databases, mous...
Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions [0.03%]
心血管病的危险因素：流行病学、筛查、预防和治疗干预措施
Mowei Kong,Zaiyong Zheng,Min Huang et al.
Mowei Kong et al.
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, and the burden is particularly severe in low-income and middle-income countries. Although traditional risk factors such as hypertension, dyslipide...
Safety and Efficacy of Aumolertinib as First-Line Treatment in EGFR-Mutant Lung Adenosquamous Carcinoma: A Multicenter, Single-Arm, Prospective Phase II Study (ARISE Study) [0.03%]
奥玛环素治疗EGFR突变型肺腺鳞癌一线患者的疗效和安全性：多中心、单组、前瞻性Ⅱ期临床研究（ARISE研究）
Longfeng Zhang,Long Huang,Dingzhi Huang et al.
Longfeng Zhang et al.
Lung adenosquamous carcinoma (ASC) is a rare histological subtype of non-small cell lung cancer (NSCLC), and prospective data regarding the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in this patien...
Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance [0.03%]
肿瘤塑性和微环境互作驱动转移和耐药
Gunjan Dagar,Manisha Dagar,Ashna Gupta et al.
Gunjan Dagar et al.
Metastasis remains the leading cause of cancer-related mortality and is increasingly recognized as a consequence of dynamic interactions between tumor cell plasticity and a heterogeneous tumor microenvironment (TME). Rather than being genet...
SIRT Family: Biological Functions and Therapeutic Targets [0.03%]
长寿蛋白沉默信息调节因子21(SIRT)家族：生物学功能及药理作用研究进展
Jia-Yi Wang,Feng-Li Jiang,Fang-Yuan Zhang et al.
Jia-Yi Wang et al.
Sirtuins (SIRT1-SIRT7) are nicotinamide adenine dinucleotide (NAD+) dependent deacylases that serves as metabolic sensors, coupling cellular energy status to chromatin structure, mitochondrial function, and stress responses. Dysregulated SI...
Early-Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection [0.03%]
早期前列腺癌的流行病学、危险因素、生物学特性、临床特点、治疗及早诊早治措施
Xingyu Xiong,Weizhen Zhu,Weichao Huang et al.
Xingyu Xiong et al.
The incidence of early-onset prostate cancer (EOPC) is rising, and by 2045 a 24.5% increase in cases and a 50% rise in mortality are projected. Accumulating evidence indicates that EOPC represents a distinct disease entity, characterized by...
Precision Stereotactic Body Radiotherapy for Ultra-Central NSCLC: Tailored Margins Reduce Toxicity Without Compromising Tumor Control [0.03%]
精准立体定向体放射治疗超中心型肺癌：量身定制的边缘范围可减少毒性而不影响肿瘤控制能力
Di Liu,Shuangyan Yang,Yun Chen et al.
Di Liu et al.
Stereotactic body radiation therapy (SBRT) is effective for early-stage non-small cell lung cancer (NSCLC), but the treatment of ultra-central NSCLC (UCNLC) near critical structures remains challenging. This retrospective study analyzed 66 ...