Development of a Trivalent Seasonal Influenza Vaccine Using Long α-Helix-Mediated Trimeric HA1 Proteins Produced in Baculovirus-Insect Cell System [0.03%]
利用杆状病毒-昆虫细胞系统开发三价季节性流感疫苗的研究
Ning Guo,Zhibin Xu,Xinyu Chen et al.
Ning Guo et al.
The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets [0.03%]
炎症和免疫在心血管疾病中的作用：分子机制和治疗靶点
Jiaxiang Rong,Zhen Wang,Xiaoxiao Lin et al.
Jiaxiang Rong et al.
Cardiovascular inflammation is increasingly recognized not merely as a secondary response to hemodynamic or metabolic injury, but as a determinant of disease initiation, progression, and remodeling. In the injured heart and vasculature, dan...
Du Tang,Wang Lin,Hengyang Liu et al.
Du Tang et al.
Lymphatic endothelial cells (LECs) line the lymphatic vasculature and support interstitial fluid drainage, lipid transport, and immune-cell trafficking. Beyond these classical functions, recent studies now recognize LECs as heterogeneous, s...
Na Zhang,Li Wei,Cuiping Tang et al.
Na Zhang et al.
The MYC oncogene family constitutes a master regulatory hub in tumorigenesis, with functional complexity extending far beyond individual gene activities. Recent advances unveil cooperative yet context-dependent antagonism and dynamic interp...
Targeting Elastin-Derived Peptides Reverses Alveolar Epithelial Dysfunction in Chronic Obstructive Pulmonary Disease [0.03%]
靶向弹力蛋白衍生肽可逆转慢性阻塞性肺疾病肺泡上皮细胞功能障碍
Huijuan Zhu,Yiling Zhao,Yingchao Qin et al.
Huijuan Zhu et al.
Chronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar destruction and defective regeneration, yet the matrix-derived factors contributing to this process remain poorly defined. We investigated the role of ela...
Bihang Sun,Linqing Wen,Shiyun Tang et al.
Bihang Sun et al.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro-inflammatory)/M2 (anti-inflammatory) dichotomy. Under homeo...
Xinyuan Wu,Jingrao Zhang,Mengdi Xu et al.
Xinyuan Wu et al.
Robotic systems are entering clinical care, but full autonomy remains constrained by patient variability, safety requirements, dynamic clinical environments, and the need for professional oversight. Human-robot collaboration (HRC) offers a ...
Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis [0.03%]
结核病的发病机制：宿主抗结核免疫与结核分枝杆菌免疫逃避策略间的相互作用
Xiaojuan Zhang,Ying Liu,Yilin Hou et al.
Xiaojuan Zhang et al.
Tuberculosis remains one of the leading causes of death from a single infectious pathogen worldwide, despite the availability of antituberculosis chemotherapy and Bacillus Calmette-Guérin vaccination. Tuberculosis pathogenesis is driven by...
Yi Tai,Zhihao Chen,Yuping Zhu et al.
Yi Tai et al.
Glucose Transporter 1 (GLUT1) is the quintessential facilitator of basal glucose uptake, indispensable for maintaining cellular energy homeostasis, particularly across the blood-brain barrier. Beyond physiological necessity, GLUT1 dysregula...
Shan Huang,Yu Zhang,Jiali Min et al.
Shan Huang et al.
Macrophages orchestrate immune responses through remarkable phenotypic plasticity, which is intrinsically linked to their ability to reprogram intracellular metabolic pathways in response to microenvironmental cues. While recent advances ha...