Deep Learning-Driven Computational Imaging for Noninvasive Monitoring System of Brain Temperature and Metabolism: A Hypothermia Validation for Acute Ischemic Stroke [0.03%]
基于深度学习的计算成像在急性缺血性脑卒中诱导低温治疗中的颅内温度与代谢无创监测系统的应用研究
Tianhang Yang,Qihan Zhang,Yilun Huang et al.
Tianhang Yang et al.
Brain temperature (BT) is a critical physiological indicator closely associated with neurological function and disease progression. However, real-time, noninvasive monitoring of BT remains a challenge due to the limitations of current techn...
Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions [0.03%]
2型糖尿病 mellitus：分子发病机制和治疗干预措施
Shinuan Fei,Xiyue Xiong,Lu Zhang et al.
Shinuan Fei et al.
Type 2 diabetes mellitus (T2D) is a pervasive metabolic disorder driven by insulin resistance and progressive pancreatic β-cell failure, with a rapidly growing global prevalence. Its pathogenesis now extends beyond hyperglycemia to encompa...
Xiao Ge,Dong Han,Jing Wang et al.
Xiao Ge et al.
The prevailing view of cold tumors as a singular immune-insensitive state is not merely imprecise, which is clinically misleading. Currently, we contend that cold tumors comprise a heterogeneous spectrum of resistance ecosystems by distinct...
Vaccination Drives Alveolar Macrophages Pool Remodeling via Training Resident Cells and Recruiting Monocyte-Derived Cells to Defend Against Multidrug-Resistant Acinetobacter baumannii [0.03%]
疫苗通过训练常驻细胞和募集单核细胞源性细胞重塑肺泡巨噬细胞池以防御多重耐药鲍曼不动杆菌
Xiaomin Zhang,Yangyang Zhou,Chuanying Xiang et al.
Xiaomin Zhang et al.
Alveolar macrophages (AMs) serves as a frontline innate barrier against pulmonary bacterial invasion. The AM pool comprises tissue-resident AMs (TR-AMs) and monocyte-derived AMs (Mo-AMs); yet how vaccination remodels the mixed AM pool for l...
A Vegan Diet Epigenetically Modulates Inflammatory Pathways and Biological Aging: Genome-Wide DNA Methylation Analysis of a One-Month Isocaloric Vegan Versus Meat-Rich Dietary Intervention [0.03%]
纯素饮食表观遗传学调节炎症通路和生物衰老：同热量的纯素与富含肉类的饮食干预的全基因组DNA甲基化分析
L Karbacher,Jerome Mertens,S Kowarschik et al.
L Karbacher et al.
We explored the epigenomic effects of vegan diet (VD) versus meat-rich diet (MR) and identified mechanisms that help to explain how VD affects epigenetic gene regulation. Genome-wide DNA methylation profiles in 48 healthy individuals were i...
CCL20 Released by Drug-Tolerant Persisters Impairs Immunotherapy in EGFR- Mutant Lung Adenocarcinoma [0.03%]
药物富集型持续存在者释放的CCL20通过影响携带EGFR突变的肺腺癌患者从而削弱免疫治疗的效果
Hoi-Hin Kwok,Jiashuang Yang,Nerissa Chui-Mei Lee et al.
Hoi-Hin Kwok et al.
EGFR-mutant lung adenocarcinoma (LUAD) is typically associated with an immunosuppressive tumor immune microenvironment (TIME) and poor responses to PD-1 blockade. However, the contribution of drug-tolerant persister cells (DTPs) to immunoth...
Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis-Linked Remodeling [0.03%]
阻塞性睡眠呼吸暂停的流行病学、发病机制、并发症、诊断和管理及新近发现的相关纤维化重塑
Nhi Ho Thi Thuy,Thị Hằng Giang Phan,Ali Hussein Eid et al.
Nhi Ho Thi Thuy et al.
Obstructive sleep apnea (OSA) is a highly prevalent yet substantially underdiagnosed sleep-related breathing disorder increasingly recognized as a heterogeneous systemic disease rather than a purely mechanical consequence of recurrent upper...
PD-1hiCXCR5-CD4+T Peripheral Helper Cells Were Enriched and Potentially Predicted Clinical Response to Etanercept Therapy in Rheumatoid Arthritis [0.03%]
PD-1hiCXCR5-CD4+T周围型辅助性T细胞在类风湿关节炎中富集并可能预测依那西普治疗的临床疗效
Haojie Xu,Wanki Ho,Lulu Cao et al.
Haojie Xu et al.
Rheumatoid arthritis (RA) remains a challenging autoimmune disease with variable treatment responses to tumor necrosis factor-α (TNF-α) inhibitors. This study investigates the clinical significance of PD-1hiCXCR5-CD4+T peripheral helper (...
Harnessing Tumor-Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma [0.03%]
利用肿瘤特异性转录本多样性发现胰腺导管腺癌的共享新抗原库
Jingjing Zhao,Qiaojuan Li,Peng Lin et al.
Jingjing Zhao et al.
Pancreatic ductal adenocarcinoma (PDAC) is refractory to immunotherapy due to its immunologically cold microenvironment and the scarcity of mutation-derived neoantigens. Here, we introduce NeoAPP, a computational tool designed to systematic...
Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities [0.03%]
癌症中的氨基酸和脂质代谢：机制与治疗机会
Zixu Wang,Xin Fu,Jingchao Bai et al.
Zixu Wang et al.
Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape. Beyond the well-defined glycolysis, dysregulated amino acid and lipid metabolism also regulate tumor growth, stress adaptation, and therapeuti...