Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity [0.03%]
镓复合物K6通过增加活性氧水平诱导DNA损伤并增强PTEN活性来抑制结直肠癌
Wei Li,Chuanyu Yang,Zhuo Cheng et al.
Wei Li et al.
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In the clinical realm, platinum-based drugs hold an important role in the chemotherapy of CRC. Nonetheless, a multitude of patients, due to tumor protein 53 (TP53) ge...
The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside [0.03%]
天然产物作用于代谢障碍的细胞和分子靶点：一种转化方法以达到临床应用
Xiaofei Shen,Hongling Yang,Yang Yang et al.
Xiaofei Shen et al.
Metabolic disorders, including obesity, dyslipidemia, diabetes, nonalcoholic fatty liver disease, and metabolic syndrome, are characterized by insulin resistance, abnormalities in circulating cholesterol and lipid profiles, and hypertension...
Single-cell RNA sequencing reveals reduced intercellular adhesion molecule crosstalk between activated hepatic stellate cells and neutrophils alleviating liver fibrosis in hepatitis B virus transgenic mice post menstrual blood-derived mesenchymal stem cell transplantation [0.03%]
单细胞RNA测序揭示了月絨膜间充质干细胞移植后乙型肝炎病毒转基因小鼠活化肝星状细胞和中性粒细胞之间低分子细胞间粘附分子的交叉对话从而减轻肝纤维化
Lijun Chen,Yuqi Huang,Ning Zhang et al.
Lijun Chen et al.
Liver fibrosis can cause hepatitis B virus (HBV)-associated hepatocellular carcinoma. Menstrual blood-derived mesenchymal stem cells (MenSCs) can ameliorate liver fibrosis through paracrine. Single-cell RNA sequencing (scRNA-seq) may be use...
Xia Wang,Ben He
Xia Wang
Cardiovascular disease (CVD) and its complications are a leading cause of death worldwide. Endothelial dysfunction plays a crucial role in the initiation and progression of CVD, serving as a pivotal factor in the pathogenesis of cardiovascu...
Development of a genome atlas for discriminating benign, preinvasive, and invasive lung nodules [0.03%]
开发基因组图谱以区分良性的、癌前的和侵袭性的肺结节
Peng Liang,Minhua Peng,Jinsheng Tao et al.
Peng Liang et al.
To tackle misdiagnosis in lung cancer screening with low-dose computed tomography (LDCT), we aimed to compile a genome atlas for differentiating benign, preinvasive, and invasive lung nodules and characterize their molecular pathogenesis. W...
Cancer-associated fibroblast-derived colony-stimulating factor 2 confers acquired osimertinib resistance in lung adenocarcinoma via promoting ribosome biosynthesis [0.03%]
癌相关成纤维细胞衍生的粒细胞-巨噬细胞集落刺激因子通过促进核糖体合成介导肺癌上皮生长因子受体突变型腺癌对第三代表厄洛替尼耐药性获得机制研究
Yutang Huang,Xiaoqing Wang,Chunjie Wen et al.
Yutang Huang et al.
Acquired resistance is a major obstacle to the therapeutic efficacy of osimertinib in lung adenocarcinoma (LUAD), but the underlying mechanisms are still not fully understood. Cancer-associated fibroblasts (CAFs) are the most abundant strom...
Decisive reversal of lethal coronavirus disease 2019 in senescent hamster by synchronic antiviral and immunoregulatory intervention [0.03%]
同步抗病毒和免疫调节干预可逆转老年鼠严重新型冠状病毒肺炎
Xuan Liu,Ming Zhou,Mujing Fang et al.
Xuan Liu et al.
The poor prognosis observed in elderly individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a serious clinical burden and the underlying mechanism is unclear, which necessities detailed investigatio...
Mingming You,Nan Chen,Yuanyuan Yang et al.
Mingming You et al.
Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota-gut-brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognit...
Xiaojie Chen,Di Wu,Zhong Chen
Xiaojie Chen
Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli-responsive nanomaterials that can respond to endogenous o...
Different depths of food restriction and high-fat diet refeeding in mice impact host obesity and metabolic phenotypes with correlative changes in the gut microbiota [0.03%]
不同深度的食物限制和高脂饮食对小鼠宿主肥胖及代谢表型相关联的肠道菌群的影响
Jiaqi Xu,Huangru Xu,Feiyan Yang et al.
Jiaqi Xu et al.
Overweight and obesity affect almost 2 billion adults worldwide, and food restriction (FR) is commonly used to reduce body fat. Whether refeeding (Re) after FR at different ages and to different degrees leads to overweight and its possible ...