Stearoyl-CoA Desaturase-1 Drives Tumor Growth by Interacting With Histone Deacetylase-2 and Deacetylating Nucleophosmin-1 [0.03%]
硬脂酰辅酶A去饱和酶-1通过与组蛋白脱乙酰酶-2相互作用并使核仁磷酸蛋白-1脱乙酰化驱动肿瘤生长
Coline Wery,Laetitia Montero-Ruiz,Eric Bonneil et al.
Coline Wery et al.
The adaptation of lipid metabolism in cancer cells, driven by changes in the tumor microenvironment, presents major challenges for cancer therapy. Here, we addressed the problem of altered lipid metabolism and its role in cancer progression...
An Engineered Nano-Bridging Strategy Remodels the Immune Microenvironment of Esophageal Squamous Cell Carcinoma via STING Pathway Activation [0.03%]
一种通过激活STING通路重塑食管鳞癌免疫微环境的纳米桥接策略工程化方法
Chaofan Huang,Xin Tang,Yixiao Zhao et al.
Chaofan Huang et al.
Restoring macrophage-mediated phagocytosis represents a promising strategy for enhancing antitumor innate immunity. However, the highly immunosuppressive tumor immune microenvironment (TIME) of esophageal squamous cell carcinoma (ESCC) limi...
Noemí López-Rey,Alba Cabaleiro,María P Pata et al.
Noemí López-Rey et al.
Phenylketonuria (PKU), the most common autosomal‑recessive disorder of amino acid metabolism, is characterized by neurological impairment and systemic metabolic alterations caused by chronically elevated phenylalanine (Phe) levels. PKU pat...
Cross-Compartment Multimodal Analyses Reveal Differences in IL2-STAT5 Signaling Associated With Asthma in Individuals From Diverse Backgrounds [0.03%]
跨隔多模态分析揭示了与哮喘个体相关的IL2-STAT5信号通路的差异
Duan Ni,Ralph Nanan
Duan Ni
Self-reported racial background has been associated with differences in asthma risk and severity, yet detailed insights remain limited. Non-European American (EA)/non-White populations are considerably underrepresented in this context. To a...
Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview [0.03%]
氘在药物发现中的力量揭秘——全面概述
Mukta Lele,Ajit Manchare,Swapnali Parit et al.
Mukta Lele et al.
Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior. The deuterium kinetic isotope effect (KIE), which strengthe...
Hepatic Arterial Infusion Chemotherapy plus either Toripalimab or Sorafenib as First-line Therapy for Locally Advanced Hepatocellular Carcinoma: A Non-comparative, Randomized Phase 2 Trial [0.03%]
肝动脉灌注化疗联合特瑞普利单抗或索拉非尼作为不可切除的局部晚期肝细胞癌一线治疗的II期非随机研究
Zhicheng Lai,Aojie Ge,Hanyue Ouyang et al.
Zhicheng Lai et al.
This study was designed to provide prospective evidence for the combination of hepatic arterial infusion chemotherapy (HAIC) and toripalimab, which had suggested encouraging antitumor activity and safety in advanced hepatocellular carcinoma...
Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities [0.03%]
原核生物和真核生物蛋白质分泌途径：分子机制、生物学功能及治疗价值
Qiyuan Yang,Jingfei Shi,Linlin Xu et al.
Qiyuan Yang et al.
Protein secretion is a fundamental biological process essential for cellular communication, matrix remodeling, and overall homeostasis across all domains of life. While the classical endoplasmic reticulum (ER)-to-Golgi pathway has long been...
Shimeng Lv,Xia Zhong,Ruirui Shang et al.
Shimeng Lv et al.
Encephalopathy refers to diffuse brain dysfunction caused by various systemic pathological processes such as systemic infections, metabolic disorders, and organ failure. This condition poses a formidable challenge in neurocritical care, wit...
Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets [0.03%]
免疫反应的代谢调节：分子机制、疾病和治疗靶点
Chunwei Li,Ziqiang Liu,Dezheng Kong et al.
Chunwei Li et al.
Cancer-associated metabolic reprogramming profoundly reshapes the tumor microenvironment (TME), emerging as a central driver of immune evasion and therapeutic resistance. Increasing evidence indicates that metabolic enzymes function not onl...
Integrative Proteogenomic Characterization of Left-Sided and Right-Sided Colorectal Cancer [0.03%]
结肠癌和直肠癌的蛋白质基因组集成分析
An Huang,Haopeng Hong,Yonghui Sun et al.
An Huang et al.
Distinguishing characteristics have been found in the left-sided and right-sided colorectal cancer (CRC), which have different embryonic origins, molecular and clinical features. These result in differences in the efficacy of targeted thera...