Cheng Liu,Zhigang He,Yanqiong Wu et al.
Cheng Liu et al.
Sleep disorder significantly disrupts the quality of life for patients. Although it is clinically acknowledged, the fundamental neuropathological mechanisms are still not understood. Recent preclinical research has been directed toward unde...
Joseph Adu-Amankwaah,Qiang You,Xiaoer Liu et al.
Joseph Adu-Amankwaah et al.
Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic and epigenetic mechanisms collectively contribute to ...
Fusobacterium nucleatum Promotes the Growth and Metastasis of Colorectal Cancer by Activating E-Cadherin/Krüppel-Like Factor 4/Integrin α5 Signaling in a Calcium-Dependent Manner [0.03%]
口腔微生物与癌症(一):牙龈卟啉单胞菌通过激活E-钙粘素/Krüppel样因子4/整合素α5信号促进结直肠癌生长和转移的功能和机制研究
Xuebing Yan,Xiao Qu,Jiaxin Wang et al.
Xuebing Yan et al.
Gut microbiota and integrins are known to contribute to colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC in both human patie...
Carabrone Attenuates Metabolic Dysfunction-Associated Steatohepatitis by Targeting STAT3 in Mice [0.03%]
卡布拉酮通过靶向STAT3减轻小鼠与代谢功能障碍相关的脂肪性肝炎
An Pan,Jiaming Jin,Yuze Wu et al.
An Pan et al.
Metabolic dysfunction-associated steatohepatitis (MASH) has become one of the most common progressive liver diseases worldwide, but effective treatment options are severely unmet. Carabrone, a sesquiterpene lactone from the traditional Chin...
Depletion of Acetyl-CoA Carboxylase 1 Facilitates Epithelial-Mesenchymal Transition in Prostate Cancer Cells by Activating the MAPK/ERK Pathway [0.03%]
乙酰辅酶A羧化酶1的耗竭通过激活MAPK / ERK通路促进前列腺癌上皮间质转化
Jiarun Lai,Shaoyou Liu,Yupeng Chen et al.
Jiarun Lai et al.
Hyperactivation of fatty acid biosynthesis holds promise as a targeted therapeutic strategy in prostate cancer (PCa). However, inhibiting these enzymes could potentially promote metastatic progression in various other cancers. Herein, we fo...
Clinical Utility of 18Fluorine-Fibroblast Activation Protein Inhibitor-04 Positron Emission Tomography/Computed Tomography in the Evaluation of Pancreatic Ductal Adenocarcinoma: Comparison With 18Fluorine-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography [0.03%]
18氟纤维母细胞激活蛋白抑制剂-04在正电子发射断层扫描/计算机断层扫描评估胰腺导管腺癌中的临床应用：与18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的比较
Lili Lin,Guangfa Wang,Yafei Zhang et al.
Lili Lin et al.
Pancreatic ductal adenocarcinoma (PDAC) is highly susceptible to metastasis, making early detection of metastases and associated risk factors crucial for effective management. This study aimed to assess the performance of 18fluorine (18F)- ...
Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress via ERK/JNK Pathway in Hyperplastic Prostate [0.03%]
热休克蛋白家族A成员1A通过ERK/JNK通路减轻增生性前列腺的凋亡和氧化应激损伤
Huan Liu,Yongying Zhou,Zhen Wang et al.
Huan Liu et al.
Benign prostatic hyperplasia (BPH) is a prevalent disorder in aging males. It is investigated whether heat shock protein family A member 1A (HSPA1A), a cytoprotective chaperone induced under stress, has been implicated in the development of...
Tissue-Resident Memory CD8+ T Cells: Differentiation, Phenotypic Heterogeneity, Biological Function, Disease, and Therapy [0.03%]
组织驻留记忆CD8+ T细胞：分化，表型异质性，生物功能，疾病和治疗
Luming Xu,Lilin Ye,Qizhao Huang
Luming Xu
CD8+ tissue-resident memory T cells (TRM) are strategically located in peripheral tissues, enabling a rapid response to local infections, which is different from circulating memory CD8+ T cells. Their unique positioning makes them promising...
Yadi Liu,Zhongyan Sun,Dingkun Gui et al.
Yadi Liu et al.
Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6-methyladenosine (m6A). Recently, RNA modi...
PD-1/PD-L1 Inhibitors Plus Chemotherapy Versus Chemotherapy Alone as First-Line Therapy for Patients With Unfavorable Cancer of Unknown Primary: A Multicenter, Retrospective Cohort Study [0.03%]
PD-1 / PD-L1抑制剂联合化疗与单纯化疗作为主要不明癌症患者的一线治疗：一项多中心回顾性队列研究
Riqing Huang,Haifeng Li,Shuo Li et al.
Riqing Huang et al.
This multicenter study aimed to investigate the efficacy and safety of PD-1/PD-L1 inhibitors plus chemotherapy (ICI-Chemo group) versus chemotherapy alone (Chemo group) for patients with cancer of unknown primary (CUP) in the first-line set...