Development of a trophoblast organoid resource in a translational primate model [0.03%]
建立一个转化灵长类模型的胎盘滋养层类器官资源
Brady M Wessel,Jenna N Castro,Henry F Harrison et al.
Brady M Wessel et al.
First-trimester placental development comprises many critical yet understudied cellular events that determine pregnancy outcomes. Improper placentation leads to a host of health issues that not only impact the fetal period but also influenc...
Dysregulated Intestinal Nutrient Absorption in Obesity Is Associated with Altered Chromatin Accessibility [0.03%]
肥胖会改变肠道营养吸收的染色质可及性
Dilhana S Badurdeen,Zhen Li,Jeong-Heon Lee et al.
Dilhana S Badurdeen et al.
Obesity is an epidemic with myriad health effects, but little is understood regarding individual obese phenotypes and how they may respond to therapy. Epigenetic changes associated with obesity have been detected in blood, liver, pancreas, ...
Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro [0.03%]
滋养层类器官：体外捕捉早期胎盘发育的复杂性
Brady M Wessel,Jenna N Castro,Victoria H J Roberts
Brady M Wessel
First trimester placental development comprises some of the most critical yet understudied events that impact fetal development. Improper placentation leads to a host of health issues that not only impact the fetal period but also influence...
Piotr Jung,Adam J Wolpaw
Piotr Jung
Basic and translational cancer biology research requires model systems that recapitulate the features of human tumors. While two-dimensional (2D) cell cultures have been foundational and allowed critical advances, they lack the organization...
Matrigel Tunes H9 Stem Cell-Derived Human Cerebral Organoid Development [0.03%]
马特里凝胶调节H9干细胞来源的人脑类器官发育
R Chris Estridge,Jennifer E O&#x;Neill,Albert J Keung
R Chris Estridge
Human cerebral organoids are readily generated from human embryonic stem cells and human induced pluripotent stem cells and are useful in studying human neurodevelopment. Recent work with human cerebral organoids have explored the creation ...