Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery [0.03%]
基于物理的多尺度仿真模型在纳米药物载体介导血管内药物递送中的应用研究
Nicolae-Viorel Buchete,Iwona Cicha,Sutapa Dutta et al.
Nicolae-Viorel Buchete et al.
A rational design of drug nanocarriers supported by in silico modelling tools can improve the efficacy of nanosystem-based intravascular drug delivery (IVDD). Computational model development stems from the vision of replacing conventional (...
Induction of P-glycoprotein overexpression in brain endothelial cells as a model to study blood-brain barrier efflux transport [0.03%]
诱导脑内皮细胞P-糖蛋白过表达作为研究血脑屏障排泄转运体的模型
Sarah F Hathcock,Hallie E Knight,Emma G Tong et al.
Sarah F Hathcock et al.
The blood-brain barrier (BBB) is comprised of specialized brain endothelial cells (BECs) that contribute to maintaining central nervous system (CNS) homeostasis. BECs possess properties such as an array of multi-drug efflux transporters tha...
Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in growing hCMEC/D3 human brain microvessel endothelial cells [0.03%]
心磷脂的减少降低了增殖的人脑微血管内皮细胞中肌酸转运蛋白-1及肌酸的运输能力
Donald W Miller,Grant M Hatch
Donald W Miller
The phospholipid cardiolipin (CL) regulates mitochondrial energy production. Endothelial cells of the blood-brain barrier (BBB) play a vital role in uptake of metabolites into the brain and are enriched in mitochondria. We examined how defi...
Identification of transport systems involved in eflornithine delivery across the blood-brain barrier [0.03%]
识别参与博路定经血脑屏障传输的转运系统
Christopher P Watson,Gayathri Nair Sekhar,Sarah A Thomas
Christopher P Watson
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery ...
Sarah Pemberton,Demi C Galindo,Michael W Schwartz et al.
Sarah Pemberton et al.
For insulin to act within the brain, it is primarily transported from the blood across the blood-brain barrier (BBB). However, the endocytic machinery necessary for delivering insulin to the brain remains unknown. Additionally, there are pr...
Lyophilization Process Engineering and Thermostability of ID93 + GLA-SE, a Single-Vial Adjuvanted Subunit Tuberculosis Vaccine Candidate for Use in Clinical Studies [0.03%]
用于临床研究的单瓶佐剂结核病亚单位疫苗ID93+GLA-SE的冷冻干燥工艺工程和热稳定性研究
Timothy S Dutill,Michelle C Archer,Joseph McCollum et al.
Timothy S Dutill et al.
Promising clinical efficacy results have generated considerable enthusiasm for the potential impact of adjuvant-containing subunit tuberculosis vaccines. The development of a thermostable tuberculosis vaccine formulation could have signific...
Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier [0.03%]
受体介导的双特异性治疗性抗体通过血脑屏障递送药物
William M Pardridge
William M Pardridge
Therapeutic antibody drug development is a rapidly growing sector of the pharmaceutical industry. However, antibody drug development for the brain is a technical challenge, and therapeutic antibodies for the central nervous system account f...
Optimization and Characterization of a Liposomal Azithromycin Formulation for Alternative Macrophage Activation [0.03%]
用于替代巨噬变的脂质体阿奇霉素组方的优化与特征描述
Abdullah A Masud,Fahd M Alsharif,Jarrod W Creameans et al.
Abdullah A Masud et al.
Liposomal azithromycin (L-AZM) promotes macrophage polarization toward an M2-like phenotype in the context of myocardial infarction that results in improved cardiovascular outcomes in mice. To improve upon this formulation, we sought to ide...
Ngoc B Pham,Nevil Abraham,Ketki Y Velankar et al.
Ngoc B Pham et al.
Herein we report the impact of localized delivery of an anti-mouse PD-1-specific monoclonal antibody (aPD1) on Renca tumors in the resulting T cell responses and changes in broader immune gene expression profiles. Renca is a BALB/c mice syn...
Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats [0.03%]
oxytocin（OT）诱导的雄性饮食肥胖大鼠体重增加和脂肪减少的介导因素不是肩胛间棕色脂肪组织的交感神经支配
Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing energy expenditure (EE). Previous studies in our lab have sh...