The biological memory buffer hypothesis: can programmable nanocarriers shape cellular memory to improve the durability of mRNA vaccines and gene therapies? [0.03%]
可编程纳米载体塑造细胞记忆以提高mRNA疫苗和基因治疗持久性的生物记忆缓冲区假说
Okechukwu Paul-Chima Ugwu,Chinyere Nneoma Ugwu,Godson Emeka Anyanwu et al.
Okechukwu Paul-Chima Ugwu et al.
Introduction: Messenger RNA vaccines and gene therapies enable rapid and programmable biological intervention, but their therapeutic durability remains variable. Existing nanomedicine research primarily evaluates delivery...
Microplastics matter: practical implications of the EU REACH restriction for the pharmaceutical industry [0.03%]
微塑料管理不可松懈：欧盟REACH限制对制药行业的影响不容忽视
Pauline Henrica Maria Janssen,Willem Antoon Rijpkema,Lorina Bisharat et al.
Pauline Henrica Maria Janssen et al.
Synthetic polymer microparticles (SPMs), commonly referred to as microplastics, are subject to increasing restrictions due to their environmental persistence and uncertainty about potential human health effects. These substances are regulat...
Phosphosulindac (OXT-328) restores the suppressed corneal sensitivity in rabbits with dry eye disease: therapeutic implications [0.03%]
磷磺沙星(OXT-328)可恢复干眼病兔的角膜敏感性：治疗意义
Wei Huang,Ziyi Wen,Konstantinos Tourmouzis et al.
Wei Huang et al.
Background: The symptoms of dry eye disease (DED) result from activation of ocular sensory nerves and constitute the dominant component of its clinical presentation. We assessed the effect of phosphosulindac (PS), a small...
Antiparasitic triterpenic ester and ursolic acid lipid nanocapsule design, cytotoxicity, and permeability evaluation for oral delivery [0.03%]
抗寄生虫三萜酯和乌索酸脂质纳米胶束的设计、细胞毒性和口服递送渗透评价
Laura Schioppa,Cecilia Bohns Michalowski,Lucia Mamede et al.
Laura Schioppa et al.
Introduction: Ursolic acid (UA), the antimalarial triterpenic mixture 8TTE (containing C-27 feruloyl and coumaroyl esters of ursane and oleane skeletons), and the semi-synthetic antitrypanosomal derivative ursolic acid O-...
The fourth controlled release society workshop on oral peptide administration [0.03%]
第四届长效暨控释学会有关口服肽剂的研讨会
David J Brayden,Stephen T Buckley,Andrew L Lewis
David J Brayden
The Controlled Release Society (CRS, www.controlledrelease.org) held its fourth iteration of research and development in oral peptide administration on 14 July 2025 in Philadelphia (United States), entitled "Recent advances in oral peptide ...
A two-tier protection strategy for oral delivery of GLP-1 peptides: lipid-based formulation combined with enteric capsules [0.03%]
GLP-1肽口服递送的两步保护策略：脂质基药物制剂结合肠溶胶囊包裹
Camille Dumont,Vanessa Gonzalez,Paula Klatt et al.
Camille Dumont et al.
Introduction: Oral delivery of peptides is a promising alternative to invasive injectable therapies, offering improved patient adherence and convenience. Glucagon-like peptide-1 (GLP-1) analogs, in particular, are highly ...
Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery [0.03%]
脑脊液循环的变异及其对室管膜下药物输注的临床影响原因
Herbert H Engelhard,Olivier Balédent,Matthew T Borzage et al.
Herbert H Engelhard et al.
Understanding the many factors affecting the circulation of cerebrospinal fluid (CSF) is important for the treatment of neurological diseases, especially when considering macromolecular pharmaceuticals designed to be delivered directly into...
Oral delivery of biologics: from barrier-limited formulation to active convective transport [0.03%]
从屏障限制型制剂到主动对流输送口服生物制品
Sarfaraz K Niazi
Sarfaraz K Niazi
Biologic therapeutics have transformed the treatment of chronic and life-threatening diseases, yet their clinical use depends almost entirely on parenteral administration. Oral delivery is the preferred route for patients, but it remains ch...
Analytical similarity as the primary determinant of monoclonal antibody development: toward evidence-efficient regulatory frameworks [0.03%]
分析相似性作为开发单克隆抗体的主要决定因素：走向高效的监管框架
Sarfaraz K Niazi
Sarfaraz K Niazi
Monoclonal antibodies (mAbs) constitute the most rapidly expanding and therapeutically impactful class of biological medicines, driven by their exceptional target specificity, modular engineering capabilities, predictable pharmacokinetics f...
Nanoparticle-mediated mRNA delivery for cancer, autoimmunity, and genetic diseases: a rapid review [0.03%]
纳米颗粒介导的mRNA递送在癌症、自身免疫和遗传疾病中的应用：快速综述
Okechukwu Paul-Chima Ugwu,Fabian C Ogenyi,Mariam Basajja et al.
Okechukwu Paul-Chima Ugwu et al.
Introduction: Messenger RNA (mRNA) therapeutics have advanced from experimental platforms to clinical application, driven largely by the success of lipid nanoparticle (LNP)-based COVID-19 vaccines. Building on this progre...