Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets [0.03%]
几何形状对含有咖啡因的SLS打印药物片的基本性质的影响
Valerie R Levine,Christos S Katsiotis,Maria Strømme et al.
Valerie R Levine et al.
Selective Laser Sintering (SLS) has the potential to offer a more accurate alternative to current-practice manipulation of oral dosage forms for pediatric, geriatric, and dysphagia-suffering patient groups. In order to create the best possi...
Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts [0.03%]
聚乙烯醇水凝胶中Δ-9-四氢大麻酚的释放及其与人体成纤维细胞的安全相互作用
Shujun Cui,Ze Zhang,Denis Rodrigue et al.
Shujun Cui et al.
This study aimed to design a THC-rich hydrogel to deliver cannabis derivatives topically. We developed hydrogels using polyvinyl alcohol (PVA) mixed with propylene glycol (PG), vegetable glycerin (VG), or both to facilitate the dissolution ...
Electrospun patches to deliver combination drug therapy for fungal infections [0.03%]
用于真菌感染组合药物治疗的静电纺丝贴剂
Karolina Dziemidowicz,Mark Meszarik,Jacopo Piovesan et al.
Karolina Dziemidowicz et al.
Fungal infections, though affecting healthcare globally, receive insufficient attention in clinical and academic settings. Invasive fungal infections, particularly caused by combat wounds, have been identified as a critical threat by the US...
Preclinical evaluation of a novel antibiotic-eluting BioEnvelope for CIED infection prevention [0.03%]
新型抗生素洗脱BioEnvelope预防CIED感染的临床前评价
Zerelda Esquer Garrigos,John N Catanzaro,Daniel Deegan et al.
Zerelda Esquer Garrigos et al.
The risk of infection remains a significant concern with cardiovascular implantable electronic devices, necessitating the development of new strategies. This study explores the efficacy of a novel antibiotic-eluting biologic envelope design...
Investigation of novel combination therapy for age-related macular degeneration on ARPE-19 cells [0.03%]
在ARPE-19细胞中研究年龄相关性黄斑变新型联合疗法的效果调查
Madhuri Dandamudi,Peter McLoughlin,Gautam Behl et al.
Madhuri Dandamudi et al.
Age-related macular degeneration (AMD) is a multifactorial degenerative disease characterised by the gradual loss of central vision in individuals aged more than 50 years. There is currently no cure for this disease, but treatment can delay...
A selective review of inhibitors of protein kinase C gamma: a neuroplasticity-related common pathway for psychiatric illness [0.03%]
蛋白激酶Cγ抑制剂的选题回顾：精神病发病的相关神经可塑性通路
Marco Grados,Mona Salehi,Aida Lotfi et al.
Marco Grados et al.
Psychotropics are currently developed and marketed with a limited understanding of their mechanism of action. The notion that protein kinase C (PKC) activity is highly relevant to learning and memory function stems from experiments in the 1...
Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines [0.03%]
新型佐剂组合的初步结果表明，佐剂全病毒甲型H1N1流感疫苗具有增强免疫原性
Allegra Peletta,Aurélie Marmy,Samo Guzelj et al.
Allegra Peletta et al.
Due to the inherent risk of a further pandemic influenza outbreak, there is a need and growing interest in investigating combinations of prophylactic vaccines and novel adjuvants, particularly to achieve antigen dose sparing and improved im...
Dual conjugation of magnetic nanoparticles with antibodies and siRNA for cell-specific gene silencing in vascular cells [0.03%]
双抗体-siRNA修饰磁性纳米颗粒用于血管内皮细胞和平滑肌细胞的基因沉默
Katarzyna Karpinska,Lin Li,Tao Wang
Katarzyna Karpinska
RNA therapy is a rapidly expanding field and has great promise in achieving targeted gene silencing and contributing to personalized medicine. However, the delivery of RNA molecules into targeted organs or cells is still challenging. To ove...
Microneedle-enhanced drug delivery: fabrication, characterization, and insights into release and permeation of nanocrystalline imiquimod [0.03%]
微针增强药物递送：制备表征及纳米结晶型咪喹莫特释放和渗透的见解
Sophie Luise Meiser,Jonas Pielenhofer,Ann-Kathrin Hartmann et al.
Sophie Luise Meiser et al.
Transcutaneous delivery systems bear several advantages over conventional needle-based injections. Considering the low bioavailability and poor water-solubility of imiquimod, a manufacturing process has been developed to incorporate imiquim...
Receptor-mediated transcytosis for brain delivery of therapeutics: receptor classes and criteria [0.03%]
受体介导的转胞吞作用促进药物脑递送：受体分类和选择标准
Arsalan S Haqqani,Kasandra Bélanger,Danica B Stanimirovic
Arsalan S Haqqani
The delivery of therapeutics into the brain is highly limited by the blood-brain barrier (BBB). Although this is essential to protect the brain from potentially harmful material found in the blood, it poses a great challenge for the treatme...