Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs [0.03%]
一种新型脂质基口服药物递送体系及其应用
Popat Mohite,Sudarshan Singh,Anil Pawar et al.
Popat Mohite et al.
Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged...
Design of respirable sprayed microparticles of encapsulated bacteriophages [0.03%]
一种用于递送封装噬菌体的呼吸型微粒喷涂设计方法
Alberto Baldelli,Mingtao Liang
Alberto Baldelli
Antibiotic resistance is exponentially increasing, and the number of deaths caused by bacterial infections is expected to surge. When dealing with the respiratory system, inefficient antibiotics heighten the chance of death from bacterial i...
Characterization of large volume subcutaneous injections using computed tomography imaging and simultaneous pressure measurements [0.03%]
利用计算机断层扫描成像和同步压力测量表征大体积皮下注射
Mona Purcell,Sahab Babaee,Michael Galluppi et al.
Mona Purcell et al.
Many commercially available biologics, previously delivered only intravenously, are being re-formulated for subcutaneous delivery to improve patient access and compliance. However, due to inherent solubility limitations, large volume inject...
Transnasal-brain delivery of nanomedicines for neurodegenerative diseases [0.03%]
用于神经退行性疾病的鼻-脑递送纳米药物
Xu Zhang,Maohua Wang,Zhixian Liu et al.
Xu Zhang et al.
Neurodegenerative diseases (NDs) have become a serious global health problem as the population ages. Traditionally, treatment strategies for NDs have included oral and intravenous administration; however, the blood-brain barrier (BBB) can p...
Driton Vllasaliu
Driton Vllasaliu
Poor-tasting pediatric medicines: part 2. Exploring caregiver and healthcare provider values and preferences for a novel taste-blocker product to improve acceptability [0.03%]
口感较差的儿童药物（第二部分）：探索护理人员和医疗保健提供者对新型口味阻断产品改善可接受性的价值观和偏好
Moushira El-Sahn,Rose Elliott,Mona El-Sahn et al.
Moushira El-Sahn et al.
Introduction: Improving the palatability of bitter-tasting medication for pediatric populations has long presented a challenge. Taste blockers are being researched as a potential solution; however, end-user perspectives a...
Nickel nanoparticles: a novel platform for cancer-targeted delivery and multimodal therapy [0.03%]
镍纳米颗粒：一种癌症靶向递送和多模态治疗的新平台
Fengyu Wang,Sen Tong,Xuan Ma et al.
Fengyu Wang et al.
Traditional cancer treatment methods often encounter limitations, such as poor targeting, low bioavailability, and high systemic toxicity. These challenges have led researchers to explore alternative therapeutic strategies. Nickel nanoparti...
Advanced drug delivery systems for oral squamous cell carcinoma: a comprehensive review of nanotechnology-based and other innovative approaches [0.03%]
口腔鳞状细胞癌的先进药物输送系统：基于纳米技术和其他创新方法的全面回顾
Alain Herrada Céspedes,Montserrat Reyes,Javier O Morales
Alain Herrada Céspedes
Oral cancer, particularly oral squamous cell carcinoma (OSCC), poses significant challenges due to its aggressiveness, high metastatic potential, and resistance to conventional therapies. Recent advancements in drug delivery systems (DDS), ...
Poor-tasting pediatric medicines: Part 1. A scoping review of their impact on patient acceptability, medication adherence, and treatment outcomes [0.03%]
不良口味的儿科药物对其患者接受度、依从性及治疗效果影响的研究综述（上篇）
Sejal R Ranmal,Jennifer Walsh,Catherine Tuleu
Sejal R Ranmal
Background: Many medicines for children taste bitter and unpleasant, presenting a significant barrier to effective pharmacotherapy. Anecdotally, this issue is widely recognized; however, empirical evidence on the conseque...
Revolutionizing healthcare: the transformative potential of nanotechnology in medicine [0.03%]
变革医疗：纳米技术在医学中的转型潜力
Lavan K Durgam,Terry L Oroszi
Lavan K Durgam
Medical science stands on the brink of transformation thanks to nanotechnology's fast-paced development, which promises major advancements. Working with materials at the nanoscale within a 1-100 nm range allows scientists to tap into specia...