Modified dipeptide based nanospheres as a potent adjuvating delivery system for recombinant vaccines [0.03%]
一种用于重组疫苗的高效佐剂输送系统的改良型二肽基纳米球
Saikat Biswas,Nitin Yadav,Anjali Somanathan et al.
Saikat Biswas et al.
Recombinant protein vaccines offer an advantage without a safety risk in eliciting desired humoral and cell-mediated immune responses against infectious diseases. But one of their disadvantages is their low immunogenicity, thus requiring ad...
Roles of biomaterials in modulating the innate immune response in ocular therapy [0.03%]
用于眼部治疗的生物材料在调节先天性免疫反应中的作用
Mehrnoosh Rafiei,Jin Teng Chung,Ying Chau
Mehrnoosh Rafiei
The eye is a hard-to-treat organ due to its poor regenerative capacity and susceptibility to inflammation; as a result, it has an immune privilege mechanism. In the case of ocular degenerative disorders, chronic and uncontrolled ocular infl...
Nanotechnological innovations in paediatric tuberculosis management: current trends and future prospects [0.03%]
儿科结核病管理的纳米技术创新：当前趋势和未来前景
Taiwo Oreoluwa Ajayi,Madan Sai Poka,Bwalya Angel Witika
Taiwo Oreoluwa Ajayi
Paediatric Tuberculosis (TB) continues to be a major global cause of morbidity and mortality. Children are more prone to contracting TB, which can spread quickly to extrapulmonary infection sites. Although the pathophysiology of the disease...
AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery [0.03%]
经玻璃体和视网膜下注射后AAV2和AAV9在小鼠眼睛和主要组织中的靶向性和转基因表达
Sanna Koponen,Emmi Kokki,Toni Tamminen et al.
Sanna Koponen et al.
Introduction: The eye is an excellent target for gene therapy because of its anatomical features. Gene therapy to treat ocular disorders relies on efficient gene delivery and transgene expression in the target cells. The aim of this study w...
Molecular distribution in intradermal injection for transfer and delivery of therapeutics [0.03%]
皮下注射递送药物的分子分布研究
Emran O Lallow,Kishankumar J Busha,Sarah H Park et al.
Emran O Lallow et al.
Intradermal (ID) injection is a technique widely used in laboratorial and clinical applications. The boundary of the dome-like bleb formed during injection is assumed to represent the lateral extent of the injected material. This work syste...
Impact of simulated brain interstitial fluid flow on the chemokine CXCL12 release from an alginate-based hydrogel in a new 3D in vitro model [0.03%]
一种新的体外三维模型中模拟脑间质液流对藻酸盐基水凝胶中趋化因子CXCL12释放的影响
Wiam El Kheir,Anaïs Dumais,Maude Beaudoin et al.
Wiam El Kheir et al.
Introduction: Extensive investigation has been undertaken regarding drug delivery systems for the management of glioblastoma multiforme (GBM). The infiltrative behavior of GBM cells within the brain tissue is primarily attributed to their h...
Mannose-functionalization of reconstituted high-density lipoprotein nanoparticles improves payload delivery and enhances M2-to-M1 phenotype reprogramming of RAW 264.7 macrophages polarized by B16-F10 melanoma cells [0.03%]
甘露糖修饰的重组高密度脂蛋白纳米颗粒改善负载递送并增强B16-F10黑色素瘤细胞极化RAW 264.7巨噬细胞向M1表型重编程研究
Akpedje S Dossou,Morgan E Mantsch,Nirupama Sabnis et al.
Akpedje S Dossou et al.
The targeting and conversion of the immunosuppressive (M2) tumor-associated macrophages (TAMs) to an immunostimulatory (M1) phenotype can induce tumor regression in advanced melanoma. We have previously characterized and reported the abilit...
Usefulness of direct intratumoral administration of doxorubicin hydrochloride with an electro-osmosis-assisted pump [0.03%]
电渗驱动下盐酸多柔比星直接瘤内注射给药的可行性及疗效研究
Ayu Ito,Shoko Itakura,Yuya Hasegawa et al.
Ayu Ito et al.
Patients receiving chemotherapy by intravenous (i.v.) or oral administration of anticancer drugs often experience side effects. In this study, an electro-osmotic flow (EO) pump was used for the direct administration of an anticancer drug wi...
Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison [0.03%]
渗透增强剂Penetramax和EGTA在时间和空间上的上皮动力学差异。机制对比研究
D A Panou,S F Pedersen,M Kristensen et al.
D A Panou et al.
Absorption of therapeutic peptides like glucagon-like peptide or insulin for diabetes therapy upon oral administration is highly restricted by the tight junction (TJ) proteins interconnecting the cells comprising the intestinal epithelium. ...
Biodistribution of the saponin-based adjuvant Matrix-M™ following intramuscular injection in mice [0.03%]
Matrix-M™植物鞘氨醇苷类佐剂的肌肉注射小鼠体内分布研究
Cecilia Carnrot,Berit Carow,Anna-Karin E Palm et al.
Cecilia Carnrot et al.
Novel adjuvants are extensively utilized in the development of safe and effective vaccines against emerging pathogens. Matrix-M™ adjuvant is a saponin-based adjuvant used in several active clinical development programs and in widespread us...