Editorial: Modelling of intravascular drug delivery using nanocarriers [0.03%]
论点：使用纳米载体进行血管内药物输送的建模研究
Panagiotis Neofytou,Nicolae-Viorel Buchete
Panagiotis Neofytou
Editorial: Recent advancements and developments in targeted drug delivery systems for cancer diagnosis and therapy [0.03%]
评论：癌症诊断与治疗的靶向药物递送系统近期研究进展及未来展望
Abhishesh Kumar Mehata,Bipin Chaurasia,Ana Isabel Fraguas-Sánchez
Abhishesh Kumar Mehata
Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases [0.03%]
用于治疗神经退行性疾病的药物穿越血脑屏障的递送策略
Xiaopei Zhang,Manfei Fu,Yuanfei Wang et al.
Xiaopei Zhang et al.
The blood-brain barrier (BBB) restricts development of drug delivery systems for brain, which hinders the potential applications of numerous pharmaceutical agents for treating central nervous system (CNS) diseases. A number of drug delivery...
Development of a depot formulation with an in situ non-lamellar liquid crystal-forming system with phospholipids [0.03%]
一种含有磷脂的原位非液晶形成系统的长效注射制剂的研究开发
Hiroaki Todo,Rina Niki,Akie Okada et al.
Hiroaki Todo et al.
Non-lamellar liquid crystal (NLLC) structures have gained increasing attention for the controlled release of entrapped drugs. In the present study, an in situ NLLC structure-forming depot formulation through contact with water was developed...
On a model-based approach to improve intranasal spray targeting for respiratory viral infections [0.03%]
基于模型的改进鼻喷雾给药靶向以应对呼吸道病毒感染的方法研究
Mohammad Mehedi Hasan Akash,Yueying Lao,Pallavi A Balivada et al.
Mohammad Mehedi Hasan Akash et al.
The nasopharynx, at the back of the nose, constitutes the dominant initial viral infection trigger zone along the upper respiratory tract. However, as per the standard recommended usage protocol ("Current Use", or CU) for intranasal sprays,...
José M Lanao
José M Lanao
Editorial: Strategies to overcome the barriers to effective inhaled treatments [0.03%]
editorial：克服有效吸入治疗障碍的策略
Philip Chi Lip Kwok,Mohammad A M Momin,Basanth Babu Eedara et al.
Philip Chi Lip Kwok et al.
CRISPR-mediated optogene expression from a cell-specific endogenous promoter in retinal ON-bipolar cells to restore vision [0.03%]
利用CRISPR在视网膜ON双极细胞的特异性内源启动子表达光基因以恢复视力
A Maddalena,S Kleinlogel
A Maddalena
Retinitis pigmentosa, an inherited form of retinal degeneration, is characterized by a progressive loss of rods and subsequent degeneration of cones, leading to blindness. However, the remaining neural portion of the retina (bipolar and gan...
Transferrin receptor-targeting property of pabinafusp alfa facilitates its uptake by various types of human brain-derived cells in vitro [0.03%]
新型脑炎治疗药物pabinafusp alfa通过转铁蛋白受体介导的内吞作用进入各种类型的原代培养人脑细胞
Tomoki Fukatsu,Hanae Morio,Tomomi Furihata et al.
Tomoki Fukatsu et al.
Pabinafusp alfa, which is an anti-mucopolysaccharidosis II drug, consists of iduronate-2-sulfatase (IDS) genetically fused with an anti-transferrin receptor (TfR) antibody. While IDS is known to enter cells via mannose-6-phosphate receptor ...
Polyethylene Glycol-grafted poly alpha-lipoic acid-dexamethasone nanoparticles for osteoarthritis [0.03%]
聚乙二醇化聚α-左旋肉碱酸-地塞米松纳米颗粒治疗骨关节炎
Yuanqiang Cheng,Zheng Jing,Yan Xu et al.
Yuanqiang Cheng et al.
Osteoarthritis (OA) is a chronic inflammatory disease that causes synovial hyperplasia, cartilage destruction, and the formation of bone spurs. Macrophages play an indispensable role in the pathogenesis of OA by producing proinflammatory cy...