Navigating the complexity of oral peptide delivery: challenges and strategies to enhance oral bioavailability [0.03%]
口服肽药物递送的挑战及提高口服生物利用度的策略分析
Noor-Ul-Ain Khalid,Edgardo Rivera-Delgado,Thomas von Erlach
Noor-Ul-Ain Khalid
Peptide therapeutics have emerged as a rapidly expanding drug class capable of modulating highly specific and previously inaccessible molecular targets. Maximizing the clinical and commercial potential of therapeutics, particularly in chron...
Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage [0.03%]
肽和蛋白质的口服递送：药代动力学限制、负选择及途径甄别
Sarfaraz K Niazi
Sarfaraz K Niazi
Oral delivery of peptides and proteins has been pursued for over a century due to its noninvasive nature. Despite sustained innovation across multiple technological generations-such as enteric coatings, enzyme inhibitors, permeation enhance...
Food-derived molecules as regulators of intestinal tight junctions and barrier function: mechanisms and implications [0.03%]
食物源分子作为肠道紧密连接和屏障功能调节因子的作用机制及意义
Sinéad M Ryan,David J Brayden
Sinéad M Ryan
Controlling TJ permeability in the small intestine facilitates nutrient absorption, maintains luminal osmotic balance, and prevents the paracellular entry of pathogens. The pharmaceutical industry has leveraged the capacity of medium-chain ...
Correction: Colour of medicines and children's acceptability: What children think of the colour of oral dosage forms? [0.03%]
关于药物颜色和儿童接受度的纠错：孩子们对口服固体药品颜色的看法如何？
Frontiers Production Office
Frontiers Production Office
[This corrects the article DOI: 10.3389/fddev.2026.1744120.]. Keywords: acceptability; children; colour; ora...
Published Erratum
Frontiers in drug delivery. 2026 Mar 18:6:1818974. DOI:10.3389/fddev.2026.1818974 2026
Advancing transdermal drug delivery through 4D bioprinting and dynamic skin modelling [0.03%]
通过4D生物打印和动态皮肤建模推动经皮药物输送的发展
Prina Mehta
Prina Mehta
Transdermal drug delivery (TDD) provides a non-invasive approach for sustained drug release. However, traditional models present limitations in capturing the dynamic interactions between drugs, skin and the environmental factors over time. ...
Local delivery of tranexamic acid for hemorrhage control in trauma: a narrative review [0.03%]
局部应用止血芳酸治疗创伤患者：综述文章
Henry T Peng,Christian J Kastrup,Catherine Tenn et al.
Henry T Peng et al.
Background: Uncontrolled hemorrhage, often accompanied by trauma-induced coagulopathy is a leading cause of preventable death, accounting for 30%-40% of trauma fatalities. Tranexamic acid (TXA), an antifibrinolytic agent,...
Colour of medicines and children's acceptability: What children think of the colour of oral dosage forms? [0.03%]
儿童对药物颜色的看法及其可接受性：儿童如何看待口服药物的颜色？
Elisa Alessandrini,Sveinbjorn Gizurarson,Jennifer Walsh et al.
Elisa Alessandrini et al.
Background: Colour plays an important role in shaping consumer experiences, and in the context of medicines, it may influence patients' expectations, behaviours, and treatment adherence. There is limited research on how c...
Targeting F2R/PAR1 with ligand decorated lipid nanocarriers for enhanced drug delivery into ovarian cancer cells [0.03%]
靶向F2R / PAR1的配体修饰脂质纳米载体，以增强药物向卵巢癌细胞的输送
Riya Khetan,Weranga Rajapaksha,Bukuru D Nturubika et al.
Riya Khetan et al.
Ovarian cancer treatment by chemotherapy is often complicated by severe systemic toxicity, highlighting the need for targeted delivery techniques that can improve drug efficacy while minimizing off-target effects. Our previous research iden...
Anti-HER2-targeted therapies: effects on human in vitro blood-brain barrier models [0.03%]
抗HER2靶向疗法对人类体外血脑屏障模型的影响
Carolin J Curtaz,Rebecca Gebert,Achim Wöckel et al.
Carolin J Curtaz et al.
Metastatic breast cancer is associated with very poor overall survival and a reduced quality of life. HER2-positive breast cancer forms brain metastases at the late stages. Established therapies such as trastuzumab, pertuzumab, trastuzumab/...
Mechanics-guided parametric modeling of intranasal spray devices and formulations for targeted drug delivery to the nasopharynx [0.03%]
基于力学的鼻喷给药装置及制剂的参数化建模实现鼻咽部位的精准给药
Md Tariqul Hossain,Abir Malakar,Mohammad Yeasin et al.
Md Tariqul Hossain et al.
Introduction: Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and for...