Role of Angiotensin-Converting Enzyme in Cognitive Aging: Evidence from Preclinical and Clinical Studies [0.03%]
血管紧张素转化酶在认知衰老中的作用：来自前临床和临床研究的证据
Joshua Smith,Prakashkumar Dobariya,Tanvi R Kadam et al.
Joshua Smith et al.
Angiotensin-Converting Enzyme (ACE, EC 3.4.15.1), also termed as kininase II or dipeptidyl carboxypeptidase I, is a crucial component of the Renin angiotensin system (RAS). ACE is extensively recognized for its role in the regulation of the...
Across preclinical and clinical platforms, approved and investigational psychiatric drugs share pathways and associate with similar molecular functions [0.03%]
跨前临床和临床平台，已获批和研究中的精神病药物共用途径并与类似分子功能相关联
Emily Su,Nico Matthew S Valencia,Jarod Le et al.
Emily Su et al.
Introduction: Translating findings from cell and animal models to the clinic is difficult because these systems insufficiently capture human disease biology. Computational approaches, notably pathways modeling, have overc...
Global proteomics insights for a novel small compound targeting the non-integrin Laminin Receptor in a macrophage cell model [0.03%]
针对非整合素层粘连蛋白受体的新小分子化合物的全球蛋白质组学见解——以巨噬细胞为研究模型
Abigail Haffner,Manoel Figueiredo Neto,C Samuel Umbaugh et al.
Abigail Haffner et al.
Introduction: Monocytes and macrophages are the first barrier of the innate immune system, which interact with agents causing osteoarthritis or other conditions, leading to the release of proinflammatory mediators that ex...
A Small Molecule Inhibitor of Leucine Carboxyl Methyltransferase-1 Inhibits Cancer Cell Survival [0.03%]
小分子亮氨酸羧基甲基转移酶-1抑制剂通过促进外源性凋亡途径诱导癌细胞死亡
O A Arosarena,A S Saribas,E P Papadopoulos
O A Arosarena
Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases. Many malignancies are characterized by dysregulation of the delicate p...
Towards human cardiac new approach methodologies (NAMs) to evaluate the combination of repolarization prolonging and shortening drugs: a pilot study [0.03%]
人源心脏新 Approach 方法学（NAM）评估延长和缩短动作电位药物联合应用的初步研究
Robert M Geiger,Carlos Serna rd,Bhavya Bhardwaj et al.
Robert M Geiger et al.
Background and purpose: Nonclinical human cardiac new approach methodologies (NAMs), including human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) combined with multielectrode array (MEA) represent a hi...
Transduction of hematopoietic stem and progenitor cells by an MECP2 lentiviral vector improves Rett syndrome phenotypes [0.03%]
MECP2慢病毒载体转导的造血干细胞和祖细胞改善雷特综合征表型
Joseph S Anderson,Jill L Silverman,Alyse L Lodigiani et al.
Joseph S Anderson et al.
Introduction: Rett Syndrome is a genetic neurodevelopmental disorder caused by decreased levels of MeCP2. Due to mutations in the MECP2 gene, insufficient MeCP2 protein levels lead to clinical phenotypes including the los...
Multiparameter ranking of carbazoles for anti-trypanosome lead discovery [0.03%]
多参数排名在反锥虫先导物发现中对咔唑类的应用
Amrita Sharma,Carlos E Sanz-Rodriguez,Michael P Pollastri et al.
Amrita Sharma et al.
The criteria for the progression of hits in the discovery of leads for human African trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote Trypanosoma brucei, are not standardized. Hits are advanced upon meeting thres...
The critical role of mode of action studies in kinetoplastid drug discovery [0.03%]
作用机制研究在凯尼特普原生动物药物发现中的关键作用
Alan H Fairlamb,Susan Wyllie
Alan H Fairlamb
Understanding the target and mode of action of compounds identified by phenotypic screening can greatly facilitate the process of drug discovery and development. Here, we outline the tools currently available for target identification again...
Benjamin E Blass,Sumant Puri,Rishabh Sharma et al.
Benjamin E Blass et al.
Invasive candidiasis remains a significant health concern, as it is associated with a high mortality risk. In addition, the risk of infection is significantly elevated in immunocompromised patients such as those with HIV, cancer, or those t...
Charles C Hong
Charles C Hong