Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 stimulated blood [0.03%]
结核分枝杆菌ESAT-6/CFP-10抗原刺激下外周血IFN-γ、IL-2及IP-10的联合检测在LTBI诊断中的应用研究
Antony M Rapulana,Thabo Mpotje,Omolara O Baiyegunhi et al.
Antony M Rapulana et al.
Background: Accurate diagnosis of latent tuberculosis infected (LTBI) individuals is important in identifying individuals at risk of developing active tuberculosis. Current diagnosis of LTBI routinely relies on the detection and measurement...
Tafazzin deficiency causes substantial remodeling in the lipidome of a mouse model of Barth Syndrome cardiomyopathy [0.03%]
泰法辛缺乏引起巴尔特综合征心肌病小鼠模型脂质组广泛重塑
Malte Hachmann,Güntas Gülcan,Ranjithkumar Rajendran et al.
Malte Hachmann et al.
Barth Syndrome (BTHS) is a rare X-linked disease, characterized clinically by cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the phospholipid acyltransferase tafazzin (Gene: TAFAZZIN, ...
Novel therapeutic for multiple sclerosis protects white matter function in EAE mouse model [0.03%]
新型多发性硬化症疗法可保护小鼠EAE模型的白质功能
Sarah Zerimech,Hung Nguyen,Arthur A Vandenbark et al.
Sarah Zerimech et al.
Multiple sclerosis (MS) is a chronic demyelinating disease with prominent axon dysfunction. Our previous studies in an MS mouse model, experimental autoimmune encephalomyelitis (EAE), demonstrated that major histocompatibility complex Class...
Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock [0.03%]
烟酰胺核糖改善心肌细胞节律紊乱后的心功能和生存期
Pieterjan Dierickx,Bryce J Carpenter,Isaac Celwyn et al.
Pieterjan Dierickx et al.
The REV-ERB nuclear receptors are key components of the circadian clock. Loss of REV-ERBs in the mouse heart causes dilated cardiomyopathy and premature lethality. This is associated with a marked reduction in NAD+ production, but whether t...
Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis [0.03%]
选择性抑制溴结构域含有蛋白4可减少肌成纤维细胞转分化和肺纤维化
Ksenija Bernau,Melissa Skibba,Jonathan P Leet et al.
Ksenija Bernau et al.
Idiopathic pulmonary fibrosis is a lethal disease driven by myofibroblast expansion. Currently no therapies exist that target the epigenetic mechanisms controlling myofibroblast transdifferentiation, which is responsible for unregulated ext...