Impact of plant-based interventions on gynecological cancers: a narrative review of mechanistic interplays and clinical evidence [0.03%]
基于植物的干预对妇科癌症的影响：机制和临床证据的叙述性回顾
Fidelis Batale Fabrael,John Sotunsa,Kehinde Samuel Olaniyi et al.
Fidelis Batale Fabrael et al.
Gynecological cancers account for approximately 1.4 million new cases and 680,000 deaths annually. Cervical, ovarian, endometrial, vulvar, and vaginal cancers collectively impose a major and disproportionate burden on women in low- and midd...
Blood biomarkers and atrial remodeling in patients at risk of atrial fibrillation [0.03%]
血浆生物标志物与房颤高危患者的心房重构的关系
Filip Loncaric,Ilana Forado Benatar,Maria Mimbrero Guillamon et al.
Filip Loncaric et al.
Introduction: Arterial hypertension and endurance training are related to left atrial (LA) remodeling and risk of atrial fibrillation (AF). Serum blood biomarkers have been explored in relation to cardiovascular risk. Our...
Prasanna Srinivasan Ramalingam,Md Sadique Hussain,Shreyas Ramchandra Gaikwad et al.
Prasanna Srinivasan Ramalingam et al.
Frank Emmert-Streib,Shailesh Tripathi,Olli Yli-Harja
Frank Emmert-Streib
Digital twins are rapidly gaining popularity in medicine and the health sciences, as they offer not merely a new method but a versatile paradigm capable of addressing a wide range of healthcare challenges. In this paper, we provide a focuse...
Sirtuin 1 is a key molecular link between cellular senescence and heart failure [0.03%]
Sir2-like蛋白1是细胞衰老与心力衰竭的关键分子桥梁
Jan Krekora,Jarosław Drożdż,Janusz Blasiak
Jan Krekora
Cellular senescence, a state where cells permanently exit the cycle but remain metabolically active, plays a role in cardiovascular diseases (CVD), including heart failure (HF). Senescent cells accumulate in aging and stressed heart tissue,...
Molecular mechanisms underlying psoriasis and depression: an integrated analysis using mendelian randomization, transcriptomics, and single-cell sequencing [0.03%]
银屑病和抑郁的分子机制：整合性孟德尔随机化、转录组学及单细胞测序分析
Baojun De,Wenfeng Bao,Nagongbilige Hea et al.
Baojun De et al.
Background: Psoriasis, an immune-mediated systemic inflammatory disease affecting skin, vessels, and joints, often co-occurs with depression. Routine depression screening is vital, as mood disorders link to inflammation, ...
HIF1α reinforces PPARγ-dependent metabolic rechanneling to support lipid accumulation in adipocytes [0.03%]
HIF1α增强PPARγ依赖性代谢转换以促进脂肪细胞内脂质蓄积
Chaonan Zhu,Meiqian Wu,Minh Duc Pham et al.
Chaonan Zhu et al.
Introduction: Adipose tissue hypoxia is a hallmark of obesity and partly contributes to metabolic dysfunction through effects on differentiated adipocytes. Although hypoxia-inducible factor 1α (HIF1α) is a key transcrip...
CD19 exon 2 skipping is a potential prognostic correlate of anti-CD19 CAR-T therapy relapse [0.03%]
CD19外显子2跳跃可能是抗CD19 CAR-T治疗复发的潜在预后标志物
Søren Helweg Dam,Giorgia Moranzoni,Magnus Haraldson Høie et al.
Søren Helweg Dam et al.
Relapse following anti-CD19 chimeric antigen receptor (CAR) T cell therapy remains a concern in the treatment of refractory B-cell malignancies. Although the CD19Δexon2 splice variant has been linked to treatment failure, reliable pre-trea...
Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity [0.03%]
特定HLA等位基因与间质性膀胱炎的相关性提示自身免疫反应
Inna Tabansky Stern,Jiayao Wang,Robert M Moldwin et al.
Inna Tabansky Stern et al.
Interstitial cystitis/bladder pain syndrome (IC/BPS) with Hunner Lesions (Hunner Type Interstitial Cystitis or HIC) is characterized by lesions on the bladder wall. Previous work on these lesions identified B cells and monocytes within the ...
Advancing AAV vector manufacturing: challenges, innovations, and future directions for gene therapy [0.03%]
AAV载体制造技术的改进：基因治疗面临的挑战、创新及未来方向
N Charan S S Kowshik,Pushpendra Singh
N Charan S S Kowshik
Adeno-Associated Virus (AAV) vectors are at the forefront of gene therapy, offering transformative therapeutic potential for many genetic disorders. However, the translation of this promise into accessible treatments is constrained by manuf...