HIF1α reinforces PPARγ-dependent metabolic rechanneling to support lipid accumulation in adipocytes [0.03%]
HIF1α增强PPARγ依赖性代谢转换以促进脂肪细胞内脂质蓄积
Chaonan Zhu,Meiqian Wu,Minh Duc Pham et al.
Chaonan Zhu et al.
Introduction: Adipose tissue hypoxia is a hallmark of obesity and partly contributes to metabolic dysfunction through effects on differentiated adipocytes. Although hypoxia-inducible factor 1α (HIF1α) is a key transcrip...
CD19 exon 2 skipping is a potential prognostic correlate of anti-CD19 CAR-T therapy relapse [0.03%]
CD19外显子2跳跃可能是抗CD19 CAR-T治疗复发的潜在预后标志物
Søren Helweg Dam,Giorgia Moranzoni,Magnus Haraldson Høie et al.
Søren Helweg Dam et al.
Relapse following anti-CD19 chimeric antigen receptor (CAR) T cell therapy remains a concern in the treatment of refractory B-cell malignancies. Although the CD19Δexon2 splice variant has been linked to treatment failure, reliable pre-trea...
Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity [0.03%]
特定HLA等位基因与间质性膀胱炎的相关性提示自身免疫反应
Inna Tabansky Stern,Jiayao Wang,Robert M Moldwin et al.
Inna Tabansky Stern et al.
Interstitial cystitis/bladder pain syndrome (IC/BPS) with Hunner Lesions (Hunner Type Interstitial Cystitis or HIC) is characterized by lesions on the bladder wall. Previous work on these lesions identified B cells and monocytes within the ...
Advancing AAV vector manufacturing: challenges, innovations, and future directions for gene therapy [0.03%]
AAV载体制造技术的改进：基因治疗面临的挑战、创新及未来方向
N Charan S S Kowshik,Pushpendra Singh
N Charan S S Kowshik
Adeno-Associated Virus (AAV) vectors are at the forefront of gene therapy, offering transformative therapeutic potential for many genetic disorders. However, the translation of this promise into accessible treatments is constrained by manuf...
MYC is in the CARDs: CBM complexes coordinate immune and MYC-dependent cellular function [0.03%]
CBM复合体协调免疫和MYC依赖的细胞功能CARDs：CBM复相协调免疫和MYC依赖的细胞功能
Stanley B DeVore,Gurjit K Khurana Hershey
Stanley B DeVore
MYC is a transcription factor crucial for a host of cellular functions from proliferation to metabolism, and MYC dysregulation contributes to disease pathogenesis. A growing body of evidence suggests that MYC signaling is regulated by the c...
Antibody-drug conjugates targeting the cadherin, claudin and nectin families of adhesion molecules [0.03%]
靶向黏附分子Cadherins、Claudins和Nectins的抗体药物偶联物
Masuko Katoh,Yohann Loriot,Izuma Nakayama et al.
Masuko Katoh et al.
The classical cadherin (CDH), claudin (CLDN) and nectin families of transmembrane-type adhesion molecules are located at adherens or tight junctions in epithelial cells but diffuse to the nonjunctional cell surface in solid tumors with epit...
Andrew Wister,Elizaveta Pinigina,Jie Liang et al.
Andrew Wister et al.
One development in the growing field of Alzheimer's Disease and related neurological disorders (ADRD) is the consideration of brain resilience, the ability to respond to and recover from adversity, which builds on a growing literature on th...
The role of aryl hydrocarbon receptor signalling in COVID-19 pathology and its therapeutic potential [0.03%]
芳香烃受体信号在新冠肺炎病理中的作用及其治疗潜力
Saidon Mbambara,Ndimo Modipane,Thato Serite et al.
Saidon Mbambara et al.
Coronavirus disease 2019 (COVID-19), caused by the betacoronavirus SARS-CoV-2, emerged in Wuhan, China, and rapidly evolved into a global health crisis. Recent evidence highlights the activation of the aryl hydrocarbon receptor (AHR) pathwa...
Potential role of N6-methyladenosine modification in circular RNA biogenesis and function in the inflammatory responses [0.03%]
N6-甲基腺苷修饰在环状RNA生物发生及炎症反应中的潜在作用
Heedoo Lee,Leo Chen,Yang Jin
Heedoo Lee
N6-methyladenosine (m6A) is the best-studied post-transcriptional RNA modification. It refers to the methylation in the N6 position. M6A exists universally from viruses to mammalian cells and is highly abundant in RNA polymerase II-transcri...
Neural stem cells in adult neurogenesis and their therapeutic applications in neurodegenerative disorders: a concise review [0.03%]
神经干细胞在成人神经发生及神经退行性疾病治疗应用中的作用综述性研究
Teketay Bayleyegn Derso,Bemrew Admassu Mengistu,Yitayew Demessie et al.
Teketay Bayleyegn Derso et al.
The idea of using stem cell therapy to treat neurodegenerative diseases has undergone significant change over the years and has made significant progress recently. Neurotrophins, growth factors, and transcription factors regulate neural...