Cholesterol and docosahexaenoic acid likely protect against alcohol-induced constriction of cerebral arteries via a common pathway [0.03%]
胆固醇和二十二碳六烯酸通过同一通路有可能防止酒精引起的脑动脉收缩
Shiwani Thapa,Steven Mysiewicz,Alex M Dopico et al.
Shiwani Thapa et al.
Binge alcohol drinking is significantly associated with an increased risk of cerebrovascular dysfunction. Within cerebral artery smooth muscle, alcohol inhibits calcium- and voltage-gated potassium (BK) channels of large-conductance, leadin...
Identifying an initial set of core components for perinatal cannabis use harm reduction counseling: An application of the Consensus on Relevant Elements (CORE) process [0.03%]
围产期大麻使用危害减少咨询的核心组成部分初步确定：Consensus on Relevant Elements（CORE）过程的应用
Ariana M Albanese,E Ruby Cramer,Hannah E Frank et al.
Ariana M Albanese et al.
Cannabis use during pregnancy or lactation is a key topic in healthcare today. It is recommended that patients abstain from perinatal use and healthcare providers are encouraged to discuss use with patients. However, some perinatal individu...
A two-factor structure for cannabis use disorder identification test and its associations with demographic factors and cannabis use motives [0.03%]
基于大麻使用障碍识别量表的双因素结构及其与人口统计学特征和大麻使用动机的相关性
Nadine Heckel,Carlos Nordt,Etna J E Engeli et al.
Nadine Heckel et al.
Introduction: Cannabis use is linked to the risk of developing a Cannabis Use Disorder (CUD), which can often be chronic. Early identification of problematic cannabis use is crucial to lower the risk of CUD and associated...
Molecular and biochemical correlates of frontal lobe white matter degeneration in humans with alcohol use disorder [0.03%]
酒精使用障碍患者额叶白质退行性变的分子和生化标志物研究
Suzanne M de la Monte,Ming Tong,Greg Sutherland
Suzanne M de la Monte
Background: Alcohol-related brain damage caused by heavy alcohol misuse is associated with cognitive-motor impairment and white matter (WM) degeneration. Oligodendrocytes and myelin are major targets, but the underlying m...
Daniel Kretchman
Daniel Kretchman
The impact of compulsive behaviors (aka addictions), whether substance- or behavioral-based, is substantial. The acronym HALT (Hungry, Angry, Lonely, Tired) has long been used in recovery. This paper provides a discussion of the history and...
Sex differences in reward network activation are linked to problematic substance use among high-risk adolescents [0.03%]
奖赏系统激活的性别差异与高危青少年物质使用障碍有关联
Olivia K Murray,Paola P Mattey-Mora,Joseph Aloi et al.
Olivia K Murray et al.
Background: Adolescents with externalizing (EXT) disorders, such as attention-deficit/hyperactivity disorder and conduct disorder-characterized by impulsivity and rule-breaking, are at elevated risk for substance use diso...
Molecular and biochemical pathologies in human alcohol-related cerebellar white matter degeneration [0.03%]
人类酒精相关小脑白质退变的分子和生化病理学
Suzanne M de la Monte,Ming Tong
Suzanne M de la Monte
Background: Alcohol use disorder (AUD) marked by heavy chronic or binge alcohol consumption, causes cerebellar and white matter (WM) atrophy with cognitive-motor impairments. Major pathological features of alcohol-related...
Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates [0.03%]
prenatal环境暴露与大脑发育：以狒狒和其他非人类灵长类动物的研究为例
Igor Y Iskusnykh,Shiwani Thapa,Victor V Chizhikov et al.
Igor Y Iskusnykh et al.
During pregnancy, the fetal brain undergoes rapid development and is highly sensitive to environmental influences. Understanding the intricate processes that underlie fetal brain development will be critical for advancing maternal-fetal hea...
Chronic alcohol withdrawal-associated increases in VTA Hcrtr1 expression are associated with heightened nociception and anxiety-like behavior in female rats [0.03%]
长期饮酒后伏隔核HCRTR1表达增加与雌性大鼠痛觉过敏和类似焦虑的行为有关
Shealan Cruise,Maria E Secci,Leslie K Kelley et al.
Shealan Cruise et al.
Alcohol withdrawal is characterized by various symptoms that include pain and negative affect in the absence of the drug. The neural underpinnings of these behaviors are not entirely understood, but orexin has emerged as a candidate target ...
Missed opportunities: the detection and management of at-risk drinking and illicit drug use in acutely hospitalized patients [0.03%]
错失的良机：急性住院患者的问题饮酒和非法药物使用的发现与处理
Danil Gamboa,Saranda Kabashi,Benedicte Jørgenrud et al.
Danil Gamboa et al.
At-risk alcohol and illicit drug use are risk factors for disease and in-hospital complications. This study investigated whether clinicians document substance use in the electronic records of acutely hospitalized internal medicine patients....