Resting and Physical Activity Energy Expenditure Across an Altitudinal Gradient: An Adjusted Analysis [0.03%]
海拔梯度上的静息和体力活动能量消耗：调整后的分析结果
Margot Evelin Bernedo-Itusaca,Shantal Cutipa-Tinta,Judith Marie Merma-Valero et al.
Margot Evelin Bernedo-Itusaca et al.
Introduction: Survival at high altitudes requires efficient energy management. Although hypobaric hypoxia alters thermodynamic efficiency, the independent impact of altitude versus demographic factors on basal and exertio...
Higher Prevalence of Cognitive Impairment in Residents of High-Altitude Regions [0.03%]
高海拔地区居民认知障碍患病率更高
Margot Evelin Bernedo-Itusaca,Judith Marie Merma-Valero,Tatiana Milagros Cruz-Riquelme et al.
Margot Evelin Bernedo-Itusaca et al.
Introduction: A major health issue in individuals living at high-altitude regions is an increase in the number of red blood cells (RBCs). This condition generates a series of physiological alterations including the nervou...
HIF-1α Signaling in Uterine Fibroids: A Central Integrator of Hypoxic, Hormonal, and Fibrotic Pathways [0.03%]
低氧诱导因子-1α信号通路在子宫肌瘤中的作用：缺氧、激素和纤维化途径的核心整合点
Sruthi Tatavarthi,Valentina Vanos,Abigail Lepsch Combs et al.
Sruthi Tatavarthi et al.
Uterine fibroids (leiomyomas) are common benign smooth muscle tumors that impose substantial symptom burden and healthcare costs worldwide. Although uterine fibroid (leiomyoma) pathogenesis is multifactorial, hypoxia has emerged as a key fe...
Physical Activity and Pain Perception in Residents Under Conditions of Chronic Hypoxia [0.03%]
慢性缺氧条件下居民的体力活动和疼痛感知
Margot Evelin Bernedo-Itusaca,Kely Melina Vilca-Coaquira,Ángel Gabriel Calisaya-Huacasi et al.
Margot Evelin Bernedo-Itusaca et al.
Background: (1)Previous studies indicate that individuals who engage in regular physical activity have a higher pain threshold than those who do not exercise. However, it remains unclear how this phenomenon behaves in ind...
Pain Perception Threshold in Young High-Altitude Natives After Acute Exposure to Severe Hypoxic Conditions [0.03%]
青年高原居民急性暴露于重度缺氧条件后对疼痛的感知阈值发生变化
Kely Melina Vilca-Coaquira,Angel Gabriel Calisaya-Huacasi,Jeancarlo Tejada-Flores et al.
Kely Melina Vilca-Coaquira et al.
Previous studies indicate that individuals at high altitudes have a lower pain threshold than those living at sea level. This study evaluates the differences in pain perception among young people living at an altitude of 3800 m and after ac...
Hypoxia in uterine fibroids: role in pathobiology and therapeutic opportunities [0.03%]
低氧在子宫肌瘤发病机制中的作用及治疗机会
Sydney L Olson,Razeen J Akbar,Adrianna Gorniak et al.
Sydney L Olson et al.
Uterine fibroids are the most common tumors in females affecting up to 70% of women world-wide, yet targeted therapeutic options are limited. Oxidative stress has recently surfaced as a key driver of fibroid pathogenesis and provides insigh...
The Underexplored Landscape of Hypoxia-Inducible Factor 2 Alpha and Potential Roles in Tumor Macrophages: A Review [0.03%]
缺氧诱导因子2α未被充分开发的景观及其在肿瘤相关巨噬细胞中潜在作用的研究进展综述
Kayla J Steinberger,Timothy D Eubank
Kayla J Steinberger
Low tissue oxygenation, termed hypoxia, is a characteristic of solid tumors with negative consequences. Tumor-associated macrophages (TAMs) accumulate in hypoxic tumor regions and correlate with worse outcomes in cancer patients across seve...
Molecular oxygen as a probe molecule in EPR spin-labeling studies of membrane structure and dynamics [0.03%]
分子氧在EPR自旋标记膜结构和动力学研究中的示踪剂作用
Witold K Subczynski,Justyna Widomska,Marija Raguz et al.
Witold K Subczynski et al.
Molecular oxygen (O2) is the perfect probe molecule for membrane studies carried out using the saturation recovery EPR technique. O2 is a small, paramagnetic, hydrophobic enough molecule that easily partitions into a membrane's different ph...