Therapeutic Strategies for MASH: An Update on Drug Candidates Under Investigation in Late-Phase Clinical Trials [0.03%]
MASH治疗策略： late期临床试验中正在研究的药物候选物最新进展
Samuel Dinerman,Yan Shu
Samuel Dinerman
Metabolic dysfunction-associated steatohepatitis (MASH) is rapidly becoming a leading cause of hepatocellular carcinoma and end-stage liver transplantation. Characterized by hepatic steatosis, lobular inflammation, and hepatocyte ballooning...
Evaluating Leucine, Isoleucine, and Valine Ratios in Mixed Cortical Cell Cultures Following Cortical Trauma: An In Vitro Assessment [0.03%]
体外评估脑皮质损伤后混合皮质细胞培养物中亮氨酸、异亮氨酸和缬氨酸的比例
Ezek Mathew,Nathan Jones,Katherine Hernandez et al.
Ezek Mathew et al.
Background/objectives: Traumatic brain injury (TBI) remains the most common cause of morbidity and mortality in adolescents and adults. Although numerous animal and human studies have demonstrated the beneficial effects o...
Comparison of the Differing Impacts of Lowered N-Acetylglucosaminyltransferase-Ia/b Activity on Motor and Sensory Function in Zebrafish [0.03%]
斑马鱼N-乙酰氨基葡萄糖基转移酶Ia/b活性下降对运动和感觉功能影响的比较
M Kristen Hall,Cody J Hatchett,Haris A Khan et al.
M Kristen Hall et al.
Background/objectives: Perturbation in terminal N-glycan processing is a feature of congenital disorders of glycosylation and neurological disorders. Since treatment options are limited, N-glycans are plausible therapeuti...
Contribution of Sex Differences to the Development of Cardiovascular Disease in Metabolic-Associated Steatotic Liver Disease (MASLD) [0.03%]
代谢相关脂肪肝病患者心血管疾病发生发展的性别差异及其机制
Lucy C Taylor,Gertrude Arthur,Marcella de Carvalho Cruz et al.
Lucy C Taylor et al.
Sex differences are a complex and crucial variable in developing and progressing metabolic and cardiovascular disease pathophysiology and clinical outcomes. The female sex, compared to the male sex, is protected from metabolic disturbances ...
Human Pulmonary Artery Endothelial Cells Increased Glycolysis and Decreased Nitric Oxide Synthase O-GlcNAcylation in Pulmonary Arterial Hypertension [0.03%]
人肺动脉内皮细胞在肺动脉高压中增加糖酵解和降低一氧化氮合酶O-GlcNAc酰化水平
Sarah E Basehore,Alisa Morss Clyne
Sarah E Basehore
Pulmonary arterial hypertension (PAH) is a fatal disease that primarily affects women. In PAH, endothelial cells become dysfunctional, reducing production of the vasodilator nitric oxide while increasing proliferation. Other studies suggest...
Organic Dust Exposure Enhances SARS-CoV-2 Entry in a PKC α- and ADAM-17-Dependent Manner [0.03%]
有机粉尘暴露以PKC α-和ADAM-17-依赖性方式增强SARS-CoV-2入侵
Abenaya Muralidharan,Christopher D Bauer,Claire G Nissen et al.
Abenaya Muralidharan et al.
SARS-CoV-2, the causative agent of the COVID-19 pandemic, has had a global impact, affecting millions over the last three years. Pre-existing lung diseases adversely affect the prognosis of infected COVID-19 patients, and agricultural worke...
A Practical Format to Organize Cancer Constellations Using Innate Immune System Biomarkers: Implications for Early Diagnosis and Prognostication [0.03%]
使用先天免疫系统生物标志物组织癌症构象的一种实用格式：对早期诊断和预后的影响
Martin Tobi,Harvinder Talwar,Noreen F Rossi et al.
Martin Tobi et al.
Cancer discovery is directed at the identification of a specific cancer type which allows for specific therapeutic interventions. Background/objectives: R...
Reduction of N-Acetylglucosaminyltransferase-I Activity Promotes Neuroblastoma Invasiveness and EGF-Stimulated Proliferation In Vitro [0.03%]
N-乙酰半乳糖胺转移酶I活性的降低可促进神经母细胞瘤的浸润性以及体外表皮生长因子刺激的增殖
Adam P Burch,M Kristen Hall,Debra Wease et al.
Adam P Burch et al.
Aberrant N-glycosylation has been associated with progression of the pediatric cancer neuroblastoma (NB) but remains understudied. Here we investigated oligomannose N-glycans in NB by genetic editing of MGAT1 in a human NB cell line, BE(2)-...