Influence of Hypothermic Machine Perfusion on Markers of Oxidative Stress and Early Tubular Injury in Rat Donor Kidneys Before Transplantation [0.03%]
移植前低温机械灌注对供肾大鼠氧化应激标志物和早期肾小管损伤的影响
Caleb LeGrand,Dinesh Bhattarai,Amod Sharma et al.
Caleb LeGrand et al.
Background: Hypothermic machine perfusion (HMP) has been associated with reduced delayed graft function compared with static cold storage (SCS). However, the molecular mechanisms underlying these differences during cold p...
Patient Activation: The Cornerstone of Effective Self-Management in Chronic Kidney Disease? [0.03%]
患者激活：慢性肾脏病有效自我管理的基础？
Courtney J Lightfoot,Devika Nair,Paul N Bennett et al.
Courtney J Lightfoot et al.
The importance of patient activation (i.e., the knowledge, skills, and confidence one has in managing one's own healthcare) in people with long-term conditions, including kidney disease, is growing. Enabling and empowering patients to take ...
Kristin P Kim,Caitlin E Williams,Christopher A Lemmon
Kristin P Kim
Renal fibrosis is a hallmark of end-stage chronic kidney disease. It is characterized by increased accumulation of extracellular matrix (ECM), which disrupts cellular organization and function within the kidney. Here, we review the bi-direc...
The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1 [0.03%]
通过抑制SGLT2和SGLT1对糖尿病肾病的保护作用的病理生理基础
Yuji Oe,Volker Vallon
Yuji Oe
SGLT2 inhibitors can protect the kidneys of patients with and without type 2 diabetes mellitus and slow the progression towards end-stage kidney disease. Blocking tubular SGLT2 and spilling glucose into the urine, which triggers a metabolic...
Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease [0.03%]
肥胖、体重减轻、生活方式干预与常染色体显性多囊肾病的关系
Cortney Steele,Kristen Nowak
Cortney Steele
Obesity remains a growing public health concern in industrialized countries around the world. The prevalence of obesity has also continued to rise in those with chronic kidney disease. Epidemiological data suggests those with overweight and...