Impact of progesterone on innate immunity and cell death after influenza A virus H1N1 2009 infection of lung and placental cells in vitro [0.03%]
孕酮对体外肺和胎盘细胞A(H1N1)流感病毒感染后先天免疫和细胞死亡的影响
Miranda Li,Amanda Li,Hazel Huang et al.
Miranda Li et al.
The influenza A virus (IAV) 2009 H1N1 pandemic was associated with an increased risk of maternal mortality, preterm birth, and stillbirth. The underlying mechanism for severe maternal lung disease and stillbirth is incompletely understood, ...
Using 2D and 3D pluripotent stem cell models to study neurotropic viruses [0.03%]
利用二维和三维多能干细胞模型研究嗜神经病毒
Emma LaNoce,Jeriel Dumeng-Rodriguez,Kimberly M Christian
Emma LaNoce
Understanding the impact of viral pathogens on the human central nervous system (CNS) has been challenging due to the lack of viable human CNS models for controlled experiments to determine the causal factors underlying pathogenesis. Human ...
Kristina M Adams Waldorf,Vikki M Abrahams
Kristina M Adams Waldorf
Effects of Overexpression of the Egyptian Fruit Bat Innate Immune Genes on Filovirus Infections in the Host Cells [0.03%]
埃及果蝠固有免疫基因过表达对宿主细胞丝状病毒感染的影响
Ivan V Kuzmin,Palaniappan Ramanathan,Christopher F Basler et al.
Ivan V Kuzmin et al.
Bats constitute a large and diverse group of mammals with unique characteristics. One of these is the ability of bats to maintain various pathogens, particularly viruses, without evidence of disease. The innate immune system has been implic...
Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors [0.03%]
一组卢旺达长期存活者的减弱HIV-1 Nef而非Vpu功能
Gisele Umviligihozo,Jaclyn K Mann,Steven W Jin et al.
Gisele Umviligihozo et al.
HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studi...
Highly Efficient Autologous HIV-1 Isolation by Coculturing Macrophage With Enriched CD4+ T Cells From HIV-1 Patients [0.03%]
高效富集CD4+T细胞与单核细胞共培养分离HIV-1毒种的新方法
Cristina Xufré,Tanía González,Lorna Leal et al.
Cristina Xufré et al.
We described a novel HIV autologous isolation method based in coculturing macrophages and CD4+T-cell-enriched fractions from peripheral blood collected from antiretroviral-treated (ART) HIV patients. This method allows the isolation of high...
APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants [0.03%]
APOBEC3通过选择HIV-1反转录酶中的V179I突变来为非核苷类反转录酶抑制剂耐药毒株提供优势环境
Richa Dwivedi,Youya Wang,Christopher Kline et al.
Richa Dwivedi et al.
The V179I substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is selected in humans or mouse models treated with certain nonnucleoside reverse transcriptase inhibitors (NNRTIs). While it is often observed ...
Morgan E Meissner,Nathaniel Talledge,Louis M Mansky
Morgan E Meissner
Studies of retroviruses have led to many extraordinary discoveries that have advanced our understanding of not only human diseases, but also molecular biology as a whole. The most recognizable human retrovirus, human immunodeficiency virus ...
Christopher B Whitehurst,Monica Rizk,Adonay Teklezghi et al.
Christopher B Whitehurst et al.
In most individuals, EBV maintains a life-long asymptomatic latent infection. However, EBV can induce the formation of B cell lymphomas in immune suppressed individuals including people living with HIV (PLWH). Most individuals who acquire H...
Downregulation of transcriptional activity, increased inflammation, and damage in the placenta following in utero Zika virus infection is associated with adverse pregnancy outcomes [0.03%]
宫内感染寨卡病毒感染后胎盘转录活性下降、炎症增加和损伤与不良妊娠结局有关
Patrick S Creisher,Jun Lei,Morgan L Sherer et al.
Patrick S Creisher et al.
Zika virus (ZIKV) infection during pregnancy causes serious adverse outcomes to the developing fetus, including fetal loss and birth defects known as congenital Zika syndrome (CZS). The mechanism by which ZIKV infection causes these adverse...