Seroprevalence of dengue, yellow fever, and related flaviviruses among the rural human population in Nguruman and Kerio Valley, Kenya [0.03%]
Mercy Hokah Kibathi,Edith Chepkorir,Sepha Nyatichi Mabeya et al.
Mercy Hokah Kibathi et al.
Background: Yellow fever virus (YFV) and dengue virus (DENV) are among the major re-emerging arboviruses that pose a significant threat to public health. Their associated burden and prevalence can be substantially underes...
Maryam Abdussamad,Grace Katz,Jie Cheng et al.
Maryam Abdussamad et al.
Background: In people with HIV (PWH) and suppressed viral replication by antiretroviral therapy persistent T cell activation and inflammation are important contributors of the increased risk of morbidity and mortality. CD...
Differential Type 1 IFN Gene Expression in CD14+ Placenta Cells Elicited by Zika Virus Infection During Pregnancy [0.03%]
怀孕期间寨卡病毒对胎盘CD14细胞感染引起I型IFN基因表达的差异
Nicole N Haese,Hannah Smith,Kosiso Onwuzu et al.
Nicole N Haese et al.
Zika virus (ZIKV) is an arthropod-borne Flavivirus that can also be transmitted vertically from infected mother to fetus. Infection of the fetus during pregnancy can lead to congenital malformations and severely impact fetal brain developme...
Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury [0.03%]
胎儿中枢神经系统来源的细胞外囊泡：对病毒介导的胎儿脑损伤进行非侵袭性追踪的潜力
Laura Goetzl,Angela J Stephens,Yechiel Schlesinger et al.
Laura Goetzl et al.
Introduction: Extracellular vesicles derived from the fetal central nervous system (FCNSEs) can be purified from maternal serum or plasma using the protein Contactin-2/TAG1that is expressed almost exclusively by developin...
Dimethoxycurcumin Acidifies Endolysosomes and Inhibits SARS-CoV-2 Entry [0.03%]
双甲氧基姜黄素使内溶酶体酸化并抑制SARS-CoV-2入侵
Nabab Khan,Zahra Afghah,Aparajita Baral et al.
Nabab Khan et al.
The pandemic of coronavirus disease 2019 (COVID-19) caused by infection by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) continues to take a huge toll on global health. Although improving, currently there are only limited the...
Enterovirus-D68 - A Reemerging Non-Polio Enterovirus that Causes Severe Respiratory and Neurological Disease in Children [0.03%]
肠道病毒D68：一种重新出现的非脊髓灰质炎肠道病毒，可导致儿童严重的呼吸道和神经系统疾病
Cassandra S Grizer,Kevin Messacar,Joseph J Mattapallil
Cassandra S Grizer
The past decade has seen the global reemergence and rapid spread of enterovirus D68 (EV-D68), a respiratory pathogen that causes severe respiratory illness and paralysis in children. EV-D68 was first isolated in 1962 from children with pneu...
MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site [0.03%]
MSH3同源性和潜在重组与SARS-CoV-2的furin裂解位点相关性研究
Balamurali K Ambati,Akhil Varshney,Kenneth Lundstrom et al.
Balamurali K Ambati et al.
Among numerous point mutation differences between the SARS-CoV-2 and the bat RaTG13 coronavirus, only the 12-nucleotide furin cleavage site (FCS) exceeds 3 nucleotides. A BLAST search revealed that a 19 nucleotide portion of the SARS.Cov2 g...
RSV infection of humanized lung-only mice induces pathological changes resembling severe bronchiolitis and bronchopneumonia [0.03%]
人源化呼吸道小鼠感染RSV后出现严重支气管炎和肺炎的病理变化
Chandrav De,Raymond J Pickles,Wenbo Yao et al.
Chandrav De et al.
Respiratory syncytial virus (RSV) is a substantial cause of severe lower respiratory tract infections in infants, young children, older adults, and immunocompromised individuals. There is a vital need for effective therapeutics to prevent a...
No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated [0.03%]
在喀麦隆不同HIV-1流行株的Nef介导的HLA-I和CD4下调无明显差异(喀麦隆为艾滋病大流行的发源地)
Nelson Sonela,Jaclyn Mann,Celestin Godwe et al.
Nelson Sonela et al.
HIV-1 group M (HIV-1M) lineages downregulate HLA-I and CD4 expression via their Nef proteins. We hypothesized that these Nef functions may be partially responsible for the differences in prevalence of viruses from different lineages that co...
Persistent transgene expression in peripheral tissues one year post intravenous and intramuscular administration of AAV vectors containing the alphaherpesvirus latency-associated promoter 2 [0.03%]
携带α疱疹病毒潜伏关联启动子2的腺相关病毒载体经静脉和肌肉注射后外源基因在周边组织中一年以上的持续表达
Carola J Maturana,Esteban A Engel
Carola J Maturana
Significant progress has been made in enhancing recombinant adeno-associated virus (rAAV) for clinical investigation. Despite its versatility as a gene delivery platform, the inherent packaging constraint of 4.7 kb imposes restrictions on t...