Evolution Driven By A Varying Host Environment Selects For Distinct HIV-1 Entry Phenotypes and Other Informative Variants [0.03%]
由可变宿主环境驱动的进化选择具有不同HIV-1进入表型和其他有用变异的进化
Shuntai Zhou,Nathan Long,Ronald Swanstrom
Shuntai Zhou
HIV-1 generates remarkable intra- and inter-host viral diversity during infection. In response to dynamic selective pressures of the host environment, HIV-1 will evolve distinct phenotypes - biological features that provide fitness advantag...
Chronic HCV infection promotes cytotoxicity in antigen-specific CD8+ T cells regardless of virus specificity [0.03%]
慢性HCV感染促进抗原特异性CD8+t细胞的细胞毒性不受病毒特异性的限制
Ana C Maretti-Mira,Matthew P Salomon,Angela M Hsu et al.
Ana C Maretti-Mira et al.
Introduction: Despite advancements in hepatitis C virus (HCV) infection treatment, HCV still represents a significant public health burden. Besides progressive hepatic damage, viral persistence has lasting effects on inna...
Mahamadou Diakite,Kathryn Shaw-Saliba,Chuen-Yen Lau
Mahamadou Diakite
The burden of malignancy related to viral infection is increasing in Sub-Saharan Africa (SSA). In 2018, approximately 2 million new cancer cases worldwide were attributable to infection. Prevention or treatment of these infections could red...
Wild-type Yellow fever virus in cerebrospinal fluid from fatal cases in Brazil, 2018 [0.03%]
巴西2018年黄热病死亡病例脑脊液中分离出黄热病病毒野生型毒株
Izabela Mauricio de Rezende,Adriana Regina Campolina Cenachi,Thais Alkifeles Costa et al.
Izabela Mauricio de Rezende et al.
Yellow fever virus (YFV) is the causative agent of yellow fever (YF), a hemorrhagic and viscerotropic acute disease. Severe YF has been described in approximately 15-25% of YF patients, with 20-50% of severe YF cases being fatal. Here we an...
Placental Autophagy and Viral Replication Co-localize in Human and Non-human Primate Placentae Following Zika Virus Infection: Implications for Therapeutic Interventions [0.03%]
寨卡病毒感染后人和非人灵长类动物胎盘自噬与病毒复制共定位的机制及治疗意义
Jennifer R McKinney,Maxim D Seferovic,Angela M Major et al.
Jennifer R McKinney et al.
Background: Multiple studies have shown both induction and inhibition of autophagy during Zika virus (ZIKV) infection. While some have proposed mechanisms by which autophagic dysregulation might facilitate ZIKV vertical t...
Evaluation of the immunogenicity and efficacy of an rVSV vaccine against Zika virus infection in macaca nemestrina [0.03%]
一种针对寨卡病毒的rVSV疫苗在 Pigtail 猕猴中的免疫原性和保护效果评价研究
Jennifer Tisoncik-Go,Kathleen M Voss,Thomas B Lewis et al.
Jennifer Tisoncik-Go et al.
Zika virus (ZIKV) is a mosquito-borne flavivirus that causes an acute febrile illness. ZIKV can be transmitted between sexual partners and from mother to fetus. Infection is strongly associated with neurologic complications in adults, inclu...
In vivo infection dynamics and human adaptive changes of SIVsm-derived viral siblings SIVmac239, SIVB670 and SIVhu in humanized mice as a paralog of HIV-2 genesis [0.03%]
人源化小鼠中SIVsm衍生的姊妹病毒SIVmac239、SIVB670和SIVhu的体内感染动力学及人类适应性变化作为HIV-2起源的旁系同源模型
James Z Curlin,Kimberly Schmitt,Leila Remling-Mulder et al.
James Z Curlin et al.
Simian immunodeficiency virus native to sooty mangabeys (SIVsm) is believed to have given rise to HIV-2 through cross-species transmission and evolution in the human. SIVmac239 and SIVB670, pathogenic to macaques, and SIVhu, isolated from a...
Drugs to limit Zika virus infection and implication for maternal-fetal health [0.03%]
限制寨卡病毒感染的药物及其对母胎健康的影响
Ankur Kumar,Deepak Kumar,Joyce Jose et al.
Ankur Kumar et al.
Although the placenta has robust defense mechanisms that protect the fetus from a viral infection, some viruses can manipulate or evade these mechanisms and disrupt physiology or cross the placental barrier. It is well established that the ...
Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses [0.03%]
IGHV3-30-3在新冠病毒中和抗体反应中的频繁使用
Pradeepa Pushparaj,Andrea Nicoletto,Xaquin Castro Dopico et al.
Pradeepa Pushparaj et al.
The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by so...
Modeling of vertical transmission and pathogenesis of cytomegalovirus in pregnancy: Opportunities and challenges [0.03%]
妊娠期人巨细胞病毒垂直传播和致病机制的建模：机遇与挑战
Gregory W Kirschen,Irina Burd
Gregory W Kirschen
In addition to facilitating nutrient, oxygen, and waste transfer between developing fetus and mother, the placenta provides important immune barrier function against infection. Elucidation of the complexity of placental barrier function at ...