Trail-blazing and keeping pace: building, retaining and expanding image analysis expertise [0.03%]
领航与并进：建立、保持和拓展图像分析的专业技能
David Kirchenbuechler,Mariana De Niz,Constadina Arvanitis
David Kirchenbuechler
Scientific studies are increasingly complex, involving quantification of many different experimental approaches and technologies. However, it is challenging for any individual scientist to build and retain sufficient expertise and competenc...
Bridging the gap between hepatocellular carcinoma management guidelines and personalised medicine: a Bayesian network study [0.03%]
基于贝叶斯网络的肝细胞癌治疗指南和个人化医疗之间差距的研究桥梁
Yi-Chun Wang,Daniel Bulte,Michael Brady
Yi-Chun Wang
Introduction: There are numerous treatment options available for patients with confirmed hepatocellular carcinoma (HCC). Guidelines such as Barcelona Clinic Liver Cancer (BCLC) support treatment decisions by way of a flow...
In silico analysis of Triphala-derived polyphenols as inhibitors of TIR-TIR homodimerization in the inflammatory pathway [0.03%]
三仙胶衍生的多酚抑制炎症途径中TIR-TIR二聚化的虚拟筛选及作用机制研究
Durgadevi Rajendran,Nalini Easwaran
Durgadevi Rajendran
Downstream signaling of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is mediated by the adaptor protein myeloid differentiation primary response gene 88 (MyD88). The TIR domain present in MyD88 plays a...
Quality over quantity: how to get the best results when using docking for repurposing [0.03%]
以质定量——如何在药物再利用对接中获得最佳效果
Lenin Domínguez-Ramírez,Maricruz Anaya-Ruiz,Paulina Cortés-Hernández
Lenin Domínguez-Ramírez
Molecular docking is among the fastest and most readily available computational tools to explore protein-ligand interactions. However, little effort has been put into assessing the quality of its results. In this paper, we compared eight fr...
CytoLNCpred-a computational method for predicting cytoplasm associated long non-coding RNAs in 15 cell-lines [0.03%]
CytoLNCpred-一个用于预测15种细胞系中细胞质相关长链非编码RNA的计算方法
Shubham Choudhury,Naman Kumar Mehta,Gajendra P S Raghava
Shubham Choudhury
The function of long non-coding RNA (lncRNA) is largely determined by its specific location within a cell. Previous methods have used noisy datasets, including mRNA transcripts in tools intended for lncRNAs, and excluded lncRNAs lacking sig...
MORE-RNAseq: a pipeline for quantifying retrotransposition-capable LINE1 expression based on RNA-seq data [0.03%]
MORE-RNAseq：一种基于RNA测序数据量化具备转座能力的LINE1表达的管线
Yutaka Nakachi,Jianbin Du,Risa Watanabe et al.
Yutaka Nakachi et al.
Retrotransposon long interspersed nuclear element-1 (LINE-1, L1) constitutes a large proportion of the mammalian genome. A fraction of L1s, which have no deleterious mutations in the structure, can amplify their copies via a process called ...
Integrative multi-omics study identifies sex-specific molecular signatures and immune modulation in bladder cancer [0.03%]
整合多组学研究识别出膀胱癌的性别特异性分子特征及免疫调节机制
Yizhou Wang,Priyanka Bhandary,Kevin Griffin et al.
Yizhou Wang et al.
Introduction: Bladder cancer shows distinct sex-related patterns, with male patients experiencing significantly higher incidence and female patients facing poorer survival outcomes. This study aimed to investigate the bio...
pubCounteR: an R package for interrogating published literature for experimentally-derived gene lists within a user-defined biological context [0.03%]
pubCounter：一个R包，用于在用户定义的生物学背景下对已发表文献中的实验性基因列表进行调查分析
Marina Leer,George A Soultoukis,Markus Jähnert et al.
Marina Leer et al.
Basic and clinical biomedical research relies heavily on modern large-scale datasets that include genomics, transcriptomics, epigenomics, metabolomics, and proteomics, among other "Omics". These research tools very often generate lists of c...
Exploiting subtractive genomics to identify novel drug targets and new immunogenic candidates against Bordetella pertussis: an in silico study [0.03%]
利用减法基因组学识别百日咳博德特氏菌新型药物靶点和新的免疫原候选物的计算研究
Mahshid Khazani Asforooshani,Narjes Noori Goodarzi,Behzad Shahbazi et al.
Mahshid Khazani Asforooshani et al.
Background: Bordetella pertussis, the causative agent of whooping cough, remains a significant global health concern despite the widespread availability of vaccines. The persistent reemergence of pertussis is driven by th...
Structural biology meets typography: using protein structures to inspire creative expression and connect diverse audiences [0.03%]
结构生物学与排版：利用蛋白质结构激发创造力并连接不同受众
Leonora Martínez-Núñez
Leonora Martínez-Núñez
Proteins are complex molecular machines with specific structures that determine their function. Advances in structural bioinformatics and visualization have expanded access to molecular data, most notably through the Protein Data Bank (PDB)...