Instability of LLM text embeddings for unsupervised dimension reduction of tabular data [0.03%]
大型语言模型文本嵌入的不稳定性和表格数据的无监督降维
Jun Li,Yixuan Gou,Shawn Su et al.
Jun Li et al.
Large language model (LLM) text embeddings have recently been used for supervised learning on tabular data by serializing each observation into text and then converting the text into a dense fixed-length vector. This strategy is appealing f...
In silico drug discovery pipelines targeting antibiotic resistance: from genomes to leads [0.03%]
从基因组到先导化合物：针对抗生素抗药性的药物发现.pipeline
Rohan Gupta,Pallavi Singh,Karthikeyan Ravi et al.
Rohan Gupta et al.
Antimicrobial resistance (AMR) is currently one of the leading global health threats. The evolution of drug-resistant bacterial pathogens is rapid, and there is a growing number of bacterial pathogens that have developed resistance to multi...
Functional restoration of conformational (R175H) and contact (R273H) mutant p53 by Bacillus-derived Hydroxymycotrienin A in non-small cell lung cancer: a computational approach [0.03%]
枯草芽孢杆菌来源的羟基麦角三烯素A通过计算方法逆转非小细胞肺癌中构象(R175H)和接触(R273H)突变型p53功能恢复性研究
Adeline Celina Rufus,Sidharth Kumar N,Magesh Ramasamy et al.
Adeline Celina Rufus et al.
Introduction: The TP53 mutations in Non-Small Cell Lung Cancer (NSCLC) remain a formidable clinical challenge. Current strategies, using the covalent binder APR-246, are limited by off-target toxicity and resistance. ...
Integrative phosphoproteomics reveals kinase-mediated regulation of OCIAD1 and its roles in mitochondrial quality control [0.03%]
整合式磷酸蛋白质组学揭示激酶介导的对OCIAD1的调控及其在细胞质控中的作用
Amal Fahma,Suhail Subair,Fathimathul Lubaba et al.
Amal Fahma et al.
Background: The ovarian cancer immunoreactive antigen domain-containing protein 1 (OCIAD1) is a mitochondrial protein implicated in mitochondrial morphology, energy metabolism, and differentiation. Although understudied, ...
Aisha AlMulla,Simerpreet Kaur,Prachi Balyan et al.
Aisha AlMulla et al.
Background: Pharmacogenomic (PGx) variation is an important determinant of inter-individual variability in drug response. While germline pharmacogenomics has been extensively studied, somatic alterations affecting these p...
Analysing open-source protein folding models for nanobody binding prediction [0.03%]
分析开源蛋白质折叠模型以预测纳米抗体结合能力
Yannick Vogt,Rebekka Roßberg,Jan Habermann et al.
Yannick Vogt et al.
Introduction: Antibody-based therapeutics are a rapidly expanding class of treatments, with over 200 approved candidates and thousands in clinical trials. Computational pre-filtering using protein structure prediction mod...
Clinically interpretable deep learning for breast cancer missense variant pathogenicity prediction [0.03%]
乳腺癌错义变异致病性预测的临床可解释深度学习方法
Rahaf M Ahmad,Noura AlDhaheri,Mohd Saberi Mohamad et al.
Rahaf M Ahmad et al.
Background: Missense variants in breast cancer remain diagnostically challenging due to their functional diversity and complex genomic contexts. Conventional laboratory assays for evaluating pathogenicity are labor-intens...
Network pharmacology and molecular modelling analysis of Arctium lappa phytochemicals in valproic acid-induced hepatotoxicity and pancreatitis [0.03%]
基于网络药理学和分子模拟的苍术化学成分治疗戊酸钠致肝毒性及胰腺炎作用机制研究
Mukul Shyam,Sabina Evan Prince
Mukul Shyam
Background: Valproic acid (VPA) is an antiepileptic drug commonly employed to treat epilepsy. Despite this, the clinical application of VPA is often hindered by adverse reactions. This study aims to investigate the therap...
Radiation-induced network rewiring in cancer: systems-level insights into environmental radioactivity and precision oncology [0.03%]
辐射诱发的癌症网络重构：环境放射性和精确诊疗的系统水平见解
Marckasagayam Priyadharshini,Saravanan Sekaran
Marckasagayam Priyadharshini
The impact of ionising radiation (IR) from environmental and therapeutic sources is complex and extends beyond the damage to DNA. These perturbations are conveyed by regulatory networks, such as transcription factors, microRNAs, long non-co...
Elucidating the molecular mechanisms of paeoniflorin intervention in oral lichen planus: a computational biology and bioinformatics-based research strategy [0.03%]
基于计算生物学和生物信息学的丹参素干预口腔扁平苔藓分子机制研究
Tian Zhao,Qi Chen,Liang Yu
Tian Zhao
Background: Oral lichen planus (OLP) is a chronic inflammatory mucosal disease with a risk of malignant transformation and limited long-term therapeutic options. Paeoniflorin (PF), a natural monoterpene glycoside, exhibit...