High-dimensional co-expression network analysis reveals persistent TRH gene expression throughout axolotl telencephalon regeneration [0.03%]
高维共表达网络分析揭示了TRH基因表达贯穿于墨西哥钝头螈大脑皮层再生的全过程
Iveth Gómez-Morales,Adriana P Mendizabal-Ruiz,J Alejandro Morales et al.
Iveth Gómez-Morales et al.
Introduction: The Axolotl (Ambystoma mexicanum) offers a deep insight into brain regeneration by fully reconstructing its telencephalon post-injury, a capability that most vertebrates do not have. This study aimed to iden...
CIT kinase phosphorylation as significant regulatory node for cellular checkpoints [0.03%]
细胞检查点的重要调控节点：CIT激酶磷酸化
Jaytha Thomas,Fathimathul Lubaba,Mukhtar Ahmed et al.
Jaytha Thomas et al.
Introduction: Citron Rho-interacting serine/threonine kinase (CIT) is a major cytosolic protein kinase essential for midbody organisation, abscission, and cytokinesis. Dysregulation and mutations in CIT are associated wit...
SpaLLM: a general framework for spatial domain identification with large language models [0.03%]
SpaLLM：一种用于空间领域识别的大规模语言模型通用框架
Zeyu Zou,Ziheng Duan
Zeyu Zou
Spatial transcriptomics (ST) technologies enable the profiling of gene expression while preserving spatial context, offering unprecedented insights into tissue organization. However, traditional spatial domain identification methods primari...
Integrative transcriptomic analysis reveals microglial metabolic-inflammatory crosstalk of HK2-HSPA5-TNF axis after intracerebral hemorrhage [0.03%]
整合转录组分析揭示出血性卒中后HK2-HSPA5-TNF轴介导的小胶质细胞代谢-炎症互作
Yi Zhang,Yongqian Liu,Wei Meng et al.
Yi Zhang et al.
Background: Intracerebral hemorrhage (ICH) triggers secondary brain injury through neuroinflammation, yet the interplay between metabolic reprogramming and inflammatory responses remains poorly defined. This study investi...
REST missense mutations reveal disrupted Re1 motif binding and co-repressor interactions in uterine fibroids [0.03%]
子宫肌瘤中RERE错义突变导致Re1基序结合和共抑制作用障碍
Srineevas Sriram,Chandresh Palanichamy,P T Subash et al.
Srineevas Sriram et al.
Introduction: The Re1-Silencing Transcription Factor (REST) is a master regulator of gene silencing, orchestrating transcriptional repression by tethering chromatin-modifying co-repressors to the Re1 motif of target genes...
Recent trends in machine learning and deep learning-based prediction of G-protein coupled receptor-ligand binding affinities [0.03%]
基于机器学习和深度学习的G蛋白偶联受体-配体结合亲和力预测的最新趋势
Joshua Stephenson,Konda Reddy Karnati
Joshua Stephenson
Accurately predicting protein-ligand binding affinity is key in drug discovery. Machine Learning and Deep Learning methods used in the drug discovery process have advanced the prediction of drug-target binding affinities, particularly for G...
KG2ML: integrating knowledge graphs and positive unlabeled learning for identifying disease-associated genes [0.03%]
KG2ML：结合知识图谱和正-未标注学习以识别疾病相关基因
Praveen Kumar,Vincent T Metzger,Swastika T Purushotham et al.
Praveen Kumar et al.
Background: Biomedical knowledge graphs (KGs), such as the Data Distillery Knowledge Graph (DDKG), capture known relationships among entities (e.g., genes, diseases, proteins), providing valuable insights for research. Ho...
Assessment of phylogenetic informativeness in mitochondrial and nuclear genes for mammalian systematics using sparse learning [0.03%]
基于稀疏学习的线粒体和核基因哺乳动物系统发育信息度评估研究
Carlos G Schrago,Beatriz Mello
Carlos G Schrago
Despite the growing availability of nuclear genomic data, mitochondrial genes remain the most widely used molecular markers in mammalian systematics. However, a quantitative assessment of the phylogenetic information content of mitochondria...
Angela Wang,Elena Xiao,Jason Cheng et al.
Angela Wang et al.
Background: As a driving force of the Fourth Industrial Revolution, deep learning methods have achieved significant success across various fields, including genetic and genomic studies. While individual-level genetic data...
Altered circRNAs: a novel potential mechanism for the functions of extracellular vesicles derived from platelet-rich plasma [0.03%]
外泌体circRNA：富血小板血浆衍生外泌体功能的潜在新机制
Lifeng Niu,Yanli Wang,Yao Gao et al.
Lifeng Niu et al.
Platelet-rich plasma (PRP) has been widely applied in clinical practice for tissue repair and regeneration. Recent studies have reported that large amounts of extracellular vesicles (EVs) derived from PRP (PRP-EVs) are also involved in the ...