Mammarenavirus Z Protein Myristoylation and Oligomerization Are Not Required for Its Dose-Dependent Inhibitory Effect on vRNP Activity [0.03%]
哺乳动物雷尼拉病毒Z蛋白的脂肪酰化和寡聚化不是其剂量依赖性抑制vRNA聚合酶活性所必需的条件
Haydar Witwit,Juan C de la Torre
Haydar Witwit
Background/objectives: N-Myristoyltransferase inhibitors (NMTi) represent a novel antiviral strategy against mammarenaviruses such as Lassa and Junin viruses. The Z matrix protein inhibits viral ribonucleoprotein (vRNP) a...
Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention [0.03%]
鞘脂信号传导和补体激活在胶质母细胞瘤中的作用：治疗干预的 promising 方向
Alhaji H Janneh
Alhaji H Janneh
Glioblastoma is the most common and aggressive type of malignant brain tumor with a poor prognosis due to the lack of effective treatment options. Therefore, new treatment options are required. Sphingolipids are essential components of the ...
pH-Selective Reactions to Selectively Reduce Cancer Cell Proliferation: Effect of CaS Nanostructures in Human Skin Melanoma and Benign Fibroblasts [0.03%]
基于CaS纳米结构的pH选择性反应对黑色素瘤细胞增殖的选择性抑制作用研究
Olga M Rodríguez Martínez,Michelle A Narváez Ramos,Angeliz A Soto Acevedo et al.
Olga M Rodríguez Martínez et al.
An acidic extracellular pH value (pHe) is characteristic of many cancers, in contrast to the physiologic pHe found in most benign cells. This difference in pH offers a unique opportunity to design and engineer chemicals that can be employed...
A Novel FACS-Based Workflow for Simultaneous Assessment of RedOx Status, Cellular Phenotype, and Mitochondrial Genome Stability [0.03%]
一种新颖的基于FACS的工作流程，可同时评估红氧状态，细胞表型和线粒体基因组稳定性
Patrick M McTernan,Paige S Katz,Constance Porretta et al.
Patrick M McTernan et al.
Intracellular reduction-oxidation (RedOx) status mediates a myriad of critical biological processes. Importantly, RedOx status regulates the differentiation of hematopoietic stem and progenitor cells (HSPCs), mesenchymal stromal cells (MSCs...