BET Protein Inhibition Relieves MDSC-Mediated Immune Suppression in Chronic Lymphocytic Leukemia [0.03%]
BET蛋白抑制可缓解慢性淋巴细胞白血病中的髓源性抑制细胞介导的免疫抑制作用
Erin M Drengler,Audrey L Smith,Sydney A Skupa et al.
Erin M Drengler et al.
Background: Myeloid-derived suppressor cells (MDSCs) contribute to immune suppression observed in chronic lymphocytic leukemia (CLL). MDSCs are immature myeloid cells that are hijacked during development and further repro...
The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax [0.03%]
新型抗癌药物SpiD3对ibrutinib或venetoclax耐药的CLL细胞具有细胞毒性
Alexandria P Eiken,Elizabeth Schmitz,Erin M Drengler et al.
Alexandria P Eiken et al.
Background: B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and aberrant anti-apoptotic mechanisms (e.g., BCL2) ...
Barriers and Facilitators of Use of Hydroxyurea among Children with Sickle Cell Disease: Experiences of Stakeholders in Tanzania [0.03%]
坦桑尼亚镰状细胞病儿童使用羟基脲的障碍与促进因素：利益相关者的经验
Manase Kilonzi,Hamu J Mlyuka,Fatuma Felix Felician et al.
Manase Kilonzi et al.
Factors contributing to low use of HU among SCD patients exist in high-income countries. The latter leaves a drift of literature on factors for low utilization of HU in developing countries. This study aimed to explore the factors influenci...
Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis [0.03%]
轻链稳定化：用于改善AL型淀粉样变性的治疗策略
Gareth J Morgan,Joel N Buxbaum,Jeffery W Kelly
Gareth J Morgan
Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these ligh...