Microbial Landscape of Pharmaceutical Failures: A 21-Year Review of FDA Enforcement Reports [0.03%]
药品监管中的微生物分布：对21年FDA执法报告的回顾分析
Luis Jimenez
Luis Jimenez
By analyzing Food and Drug Administration (FDA) enforcement reports from 2004 to 2025, we can determine the incidence of microbial contamination in non-sterile and sterile drugs in the United States of America and, at the same time, compare...
Jing Sun,Yingxue Xiao,Lingling Xie et al.
Jing Sun et al.
The tumor immune microenvironment (TIME) is closely involved in tumor initiation, malignant progression, immune escape, and response to immunotherapy. With the continued development of high-throughput sequencing technologies, transcriptomic...
Ching Tse,Kesen Ma
Ching Tse
Iron-containing alcohol dehydrogenases (Fe-ADHs) from hyperthermophiles represent a distinct class of oxidoreductases characterized by exceptional thermostability, catalytic versatility, and unique metal-dependent properties. Despite consid...
Medicinal Honeys from Oceania: An Updated Review on Their Bioactive Constituents and Health Applications [0.03%]
大洋洲的药用蜂蜜：其生物活性成分及健康应用的新进展综述
Maryna Lutsenko,Michela Ravelli,Gregorio Peron
Maryna Lutsenko
Medicinal honeys from Oceania have gained considerable attention due to their peculiar bioactive constituents and potential health applications. Apart from small molecules such as methylglyoxal and hydrogen peroxide, these honeys are rich i...
Lipopeptides from Bacillus Probiotics Can Target Transmembrane Receptors NOX4, EGFR, PDGFR, and OCTN2 Involved in Oxidative Stress and Oncogenesis [0.03%]
芽孢杆菌益生菌脂肽可以靶向NOX4，EGFR，PDGFR和OCTN2跨膜受体以对抗氧化应激和肿瘤发生
Evgeniya Prazdnova,Fadi Amirdzhanov,Anuj Ranjan et al.
Evgeniya Prazdnova et al.
Bacillus-derived lipopeptides are known to possess diverse biological activities, including antimicrobial and anticancer properties, though the mechanisms of such effects at the molecular level remain incompletely understood. We investigate...
Heterologous Production of Torularhodin, the Monocyclic Carotenoid with a Terminal Carboxyl Group, in Escherichia coli [0.03%]
大肠杆菌中异源生产末端含羧基的单环类胡萝卜素Torularhoderin
Miho Takemura,Takashi Maoka,Norihiko Misawa
Miho Takemura
Torularhodin is the monocyclic C40 carotenoid with the β-ring and a terminal carboxyl group at the acyclic part, with long conjugated double bonds, only synthesized in fungi called red (oleaginous) yeasts, e.g., the genera Rhodotorula and ...
Corundum Particles as Trypsin Carrier for Efficient Protein Digestion [0.03%]
用于高效蛋白质水解的蛋白酶C催化劑刚玉颗粒制备及性能研究
Sarah Döring,Birte S Wulfes,Aleksandra Atanasova et al.
Sarah Döring et al.
Reusable enzyme carriers are valuable for proteomic workflows, yet many supports are expensive or lack robustness. This study describes the covalent immobilization of recombinant trypsin on micrometer-sized corundum particles and assesses t...
Energy Recovery from Biowaste and Biomass via Gasification: A Modelling Approach [0.03%]
基于气化技术的生物质及有机废弃物能源回收研究——建模方法
Shabnam Ghanbarzadeh,Yi Yuan,Ehssan H Koupaie
Shabnam Ghanbarzadeh
The transition toward a circular bioeconomy requires efficient conversion of biogenic wastes and biomass into renewable fuels. This study explores the gasification potential of wastewater sludge (WWS) and food waste (FW), representing high ...
Enhancing Nonylphenol Biodegradation: The Role of Acetyl-CoA C-Acetyltransferase in Bacillus cereus [0.03%]
解偶联乙酰辅酶A碳链延长与 acp 硫酯键形成的非离子表面活性剂降解新机制
Fanglian Lu,Deqin Luo,Lian Yang et al.
Fanglian Lu et al.
Nonylphenol (NP) bioremediation is constrained by the scarcity of efficient and non-pathogenic degrading strains. To clarify the role of acetyl-CoA C-acetyltransferase (AtoB) in NP degradation, we generated an atoB-overexpressed strain (LY-...
Ion Mobility-Mass Spectrometry Imaging: Advances in Biomedical Research [0.03%]
离子淌度-质谱成像在生物医学研究中的进展
Mengya Liu,Chi Zhang,Lili Xu et al.
Mengya Liu et al.
Mass spectrometry imaging (MSI) visualizes the spatial distribution of biomolecules in tissues, whereas ion mobility-mass spectrometry (IM-MS) separates ions through the collision cross-section (CCS) with an inert gas, providing the structu...