Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness [0.03%]
DNA修复缺陷通过促进具有与年龄相关表型和反应性的调节性T细胞的积累来影响免疫衰老
Daan K J Pieren,Noortje A M Smits,Sandra Imholz et al.
Daan K J Pieren et al.
Decline of immune function during aging has in part been ascribed to the accumulation of regulatory T cells (Tregs) and decreased T-cell responses with age. Aside from changes to T cells that occur over a lifetime, the impact of intracellul...
Granzyme B: a double-edged sword in the response to influenza infection in vaccinated older adults [0.03%]
老年流感疫苗接种者对流感感染的免疫反应中Granzyme B的双刃剑作用
Chris P Verschoor,Graham Pawelec,Laura Haynes et al.
Chris P Verschoor et al.
Background: Influenza-specific cytolytic T lymphocytes (CTL) have a critical role in clearing the virus from the lungs, but are poorly stimulated by current inactivated influenza vaccines. Our previous work suggests that ...
Survival-Span Method: How to Qualitatively Estimate Lifespan to Improve the Study of Aging, and not Disease, in Aging Studies [0.03%]
生存期跨度法：如何定性估算寿命以改善衰老研究，并专注于研究衰老而非疾病
Julia Adelöf,Jaime M Ross,Madeleine Zetterberg et al.
Julia Adelöf et al.
Lifespan analyses are important for advancing our understanding of the aging process. There are two major issues in performing lifespan studies: 1) late-stage animal lifespan analysis may include animals with non-terminal, yet advanced illn...
Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice [0.03%]
小鼠肠道年龄相关性肠杆菌失调及肺部富集的肠道特异性细菌与肺炎链球菌感染易感性的增加有关
Rachel H McMahan,Holly J Hulsebus,Kevin M Najarro et al.
Rachel H McMahan et al.
The portion of the global population that is over the age of 65 is growing rapidly and this presents a number of clinical complications, as the aged population is at higher risk for various diseases, including infection. For example, advanc...
"An Intrinsic Program Determines Key Age-Associated Changes in Adaptive Immunity that Limit Response to Non-Pathogens." [0.03%]
固有程序决定了适应性免疫的关键年龄相关变化，限制了对非病原体的反应。
Susan L Swain,Olivia Kugler-Umana,Susan Tonkonogy
Susan L Swain
As mice age their adaptive immune system changes dramatically, leading to weakened responses to newly encountered antigens and poor efficacy of vaccines. A shared pattern emerges in the aged, with both CD4 T and B cell responses requiring h...
Anabolic Function Downstream of TOR Controls Trade-offs Between Longevity and Reproduction at the Level of Specific Tissues in C. elegans [0.03%]
雷帕霉素靶标下游的促合成功能控制着线虫中特定组织水平上的生殖与寿命间的权衡关系
Amber C Howard,Dilawar Mir,Santina Snow et al.
Amber C Howard et al.
As the most energetically expensive cellular process, translation must be finely tuned to environmental conditions. Dietary restriction attenuates signaling through the nutrient sensing mTOR pathway, which reduces translation and redirects ...
Yuxin Chu,Cheng Zhang,Min Xie
Yuxin Chu
One of the characteristics of the failing human heart is a significant alteration in its energy metabolism. Recently, a ketone body, β-hydroxybutyrate (β-OHB) has been implicated in the failing heart's energy metabolism as an alternative ...
Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against S. pneumoniae Infection [0.03%]
用于保护老年宿主免受肺炎链球菌感染的有效疫苗策略——多糖liposome包封(LEPS)技术
Manmeet Bhalla,Roozbeh Nayerhoda,Essi Y I Tchalla et al.
Manmeet Bhalla et al.
Despite the availability of licensed vaccines, pneumococcal disease caused by the bacteria Streptococcus pneumoniae (pneumococcus), remains a serious infectious disease threat globally. Disease manifestations include pneumonia, bacteremia, ...
Monica Sanchez-Contreras,Scott R Kennedy
Monica Sanchez-Contreras
Mitochondria are the main source of energy used to maintain cellular homeostasis. This aspect of mitochondrial biology underlies their putative role in age-associated tissue dysfunction. Proper functioning of the electron transport chain (E...
Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19 [0.03%]
生物学衰老的网络拓扑与针对新冠肺炎的抗老化研究指导方法论
Alan Landay,Jenna Bartley,Dishary Banerjee et al.
Alan Landay et al.
Aging has emerged as the greatest and most prevalent risk factor for the development of severe COVID-19 infection and death following exposure to the SARS-CoV-2 virus. The presence of multiple co-existing chronic diseases and conditions of ...